Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              18    1135
NP_671714                                                              18    1135
XP_006715890                                                           18    1135
XP_005250160                                                           18    1135
XP_005250159                                                           18    1135
NP_057526                                                              16    5631
NP_001185470                                                           16    5631
NP_001035548                                                           16    5631
XP_005272073                                                           16    5631
XP_005272072                                                           16    5631
NP_002847                                                              16    7355
NP_001036189                                                           16    7355
XP_006724409                                                           16    7355
XP_005261851                                                           16    7355
XP_005261850                                                           16    7355
NP_001138678                                                           16    7355
NP_002197                                                              15    9605
NP_001138468                                                           15    9605
NP_001138469                                                           15    9605
NP_055845                                                              15    9605
NP_001258975                                                           15    9605
NP_001137310                                                           15    9605
NP_808218                                                              15    9605
NP_001271439                                                           15    9605
NP_001271438                                                           15    9605
NP_060688                                                              15    9605
XP_006721567                                                           15    9605
XP_005268907                                                           15    9605
XP_005268906                                                           15    9605
XP_005268905                                                           15    9605
XP_005268904                                                           15    9605
XP_005268903                                                           15    9605
XP_005268902                                                           15    9605
XP_005268901                                                           15    9605
XP_005268899                                                           15    9605
XP_005268898                                                           15    9605
XP_005268897                                                           15    9605
XP_005268896                                                           15    9605
XP_005248150                                                           15    9605
XP_005248148                                                           15    9605
XP_005248147                                                           15    9605
XP_005248146                                                           15    9605
XP_005248145                                                           15    9605
XP_005248144                                                           15    9605
XP_005248143                                                           15    9605
XP_005248142                                                           15    9605
XP_005248141                                                           15    9605
XP_005248140                                                           15    9605
XP_005248139                                                           15    9605
XP_005246148                                                           15    9605
XP_005246145                                                           15    9605
XP_006712675                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDATLALFA 9
            EDATLAL A
Sbjct: 3733 EDATLALLA 3741
>NP_671714
          Length = 3899

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDATLALFA 9
            EDATLAL A
Sbjct: 3725 EDATLALLA 3733
>XP_006715890
          Length = 3860

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDATLALFA 9
            EDATLAL A
Sbjct: 3686 EDATLALLA 3694
>XP_005250160
          Length = 3939

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDATLALFA 9
            EDATLAL A
Sbjct: 3765 EDATLALLA 3773
>XP_005250159
          Length = 3952

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    EDATLALFA 9
            EDATLAL A
Sbjct: 3778 EDATLALLA 3786
>NP_057526
          Length = 948

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DATLALFA 9
           D TLA+FA
Sbjct: 766 DVTLAVFA 773
>NP_001185470
          Length = 941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DATLALFA 9
           D TLA+FA
Sbjct: 766 DVTLAVFA 773
>NP_001035548
          Length = 941

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DATLALFA 9
           D TLA+FA
Sbjct: 766 DVTLAVFA 773
>XP_005272073
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DATLALFA 9
           D TLA+FA
Sbjct: 766 DVTLAVFA 773
>XP_005272072
          Length = 951

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   DATLALFA 9
           D TLA+FA
Sbjct: 766 DVTLAVFA 773
>NP_002847
          Length = 479

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           +DATLAL
Sbjct: 121 QDATLAL 127
>NP_001036189
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           +DATLAL
Sbjct: 121 QDATLAL 127
>XP_006724409
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>XP_005261851
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>XP_005261850
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>NP_001138678
          Length = 1806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EDATLAL 7
           ED+TLAL
Sbjct: 446 EDSTLAL 452
>NP_002197
          Length = 1137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 671 DGTTALFA 678
>NP_001138468
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 675 DGTTALFA 682
>NP_001138469
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 578 DGTTALFA 585
>NP_055845
          Length = 3013

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2621 EDVTLAL 2627
>NP_001258975
          Length = 755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EDATLALFA 9
           EDAT  LF+
Sbjct: 212 EDATNGLFS 220
>NP_001137310
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DATLALF 8
           DAT+A+F
Sbjct: 356 DATVAIF 362
>NP_808218
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DATLALF 8
           DAT+A+F
Sbjct: 356 DATVAIF 362
>NP_001271439
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DATLALF 8
           DAT+A+F
Sbjct: 313 DATVAIF 319
>NP_001271438
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DATLALF 8
           DAT+A+F
Sbjct: 339 DATVAIF 345
>NP_060688
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EDATLA 6
            EDATLA
Sbjct: 1005 EDATLA 1010
>XP_006721567
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   DATLALF 8
           DAT+A+F
Sbjct: 319 DATVAIF 325
>XP_005268907
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 513 DGTTALFA 520
>XP_005268906
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 557 DGTTALFA 564
>XP_005268905
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 557 DGTTALFA 564
>XP_005268904
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 557 DGTTALFA 564
>XP_005268903
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 558 DGTTALFA 565
>XP_005268902
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 558 DGTTALFA 565
>XP_005268901
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 602 DGTTALFA 609
>XP_005268899
          Length = 1131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 665 DGTTALFA 672
>XP_005268898
          Length = 1162

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 715 DGTTALFA 722
>XP_005268897
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 709 DGTTALFA 716
>XP_005268896
          Length = 1181

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   DATLALFA 9
           D T ALFA
Sbjct: 715 DGTTALFA 722
>XP_005248150
          Length = 2044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 1652 EDVTLAL 1658
>XP_005248148
          Length = 3028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2636 EDVTLAL 2642
>XP_005248147
          Length = 3028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2636 EDVTLAL 2642
>XP_005248146
          Length = 3073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2681 EDVTLAL 2687
>XP_005248145
          Length = 3079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2687 EDVTLAL 2693
>XP_005248144
          Length = 3099

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2713 EDVTLAL 2719
>XP_005248143
          Length = 3105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2713 EDVTLAL 2719
>XP_005248142
          Length = 3114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2728 EDVTLAL 2734
>XP_005248141
          Length = 3119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2727 EDVTLAL 2733
>XP_005248140
          Length = 3119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2727 EDVTLAL 2733
>XP_005248139
          Length = 3120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    EDATLAL 7
            ED TLAL
Sbjct: 2728 EDVTLAL 2734
>XP_005246148
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDATLA 6
           EDATLA
Sbjct: 866 EDATLA 871
>XP_005246145
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EDATLA 6
           EDATLA
Sbjct: 994 EDATLA 999
>XP_006712675
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    EDATLA 6
            EDATLA
Sbjct: 1006 EDATLA 1011
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.131    0.334 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 351,144
Number of extensions: 398
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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