Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001276866                                                           18    1135
NP_004439                                                              18    1135
NP_001276865                                                           18    1135
NP_001005862                                                           18    1135
XP_005257197                                                           18    1135
XP_006721828                                                           18    1135
NP_001768                                                              18    1935
NP_942088                                                              18    1935
XP_005247966                                                           18    1935
XP_005247965                                                           18    1935
NP_940962                                                              17    3301
NP_945351                                                              17    3301
XP_005250386                                                           17    3301
XP_005250384                                                           17    3301
NP_005219                                                              17    4312
XP_005248564                                                           17    4312
NP_005900                                                              17    4312
NP_056494                                                              16    5631
NP_064593                                                              16    5631
NP_690621                                                              16    5631
NP_690620                                                              16    5631
NP_690619                                                              16    5631
NP_002812                                                              16    5631
NP_001257327                                                           16    5631
NP_071800                                                              16    5631
NP_789786                                                              16    7355
XP_005276824                                                           16    7355
XP_005276823                                                           16    7355
XP_005276822                                                           16    7355
XP_006726278                                                           16    7355
XP_005276821                                                           16    7355
XP_006726277                                                           16    7355
XP_005276820                                                           16    7355
XP_005276819                                                           16    7355
XP_005276818                                                           16    7355
XP_005248520                                                           16    7355
XP_005248519                                                           16    7355
XP_005248518                                                           16    7355
XP_006714633                                                           16    7355
XP_005248517                                                           16    7355
XP_006714632                                                           16    7355
XP_005248516                                                           16    7355
XP_005248515                                                           16    7355
XP_005248514                                                           16    7355
NP_001005174                                                           16    7355
NP_001005289                                                           16    7355
NP_001191230                                                           15    9605
NP_001129488                                                           15    9605
NP_001191231                                                           15    9605
NP_001129602                                                           15    9605
NP_958816                                                              15    9605
NP_000475                                                              15    9605
NP_659488                                                              15    9605
XP_006717015                                                           15    9605
>NP_001276866
          Length = 1055

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 770 EAYVMAGVG 778
>NP_004439
          Length = 1255

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 770 EAYVMAGVG 778
>NP_001276865
          Length = 1240

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 755 EAYVMAGVG 763
>NP_001005862
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 740 EAYVMAGVG 748
>XP_005257197
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 740 EAYVMAGVG 748
>XP_006721828
          Length = 1336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAVVG 9
           EAYVMA VG
Sbjct: 851 EAYVMAGVG 859
>NP_001768
          Length = 323

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AVVG
Sbjct: 248 AYILAVVG 255
>NP_942088
          Length = 305

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AVVG
Sbjct: 248 AYILAVVG 255
>XP_005247966
          Length = 293

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AVVG
Sbjct: 248 AYILAVVG 255
>XP_005247965
          Length = 312

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AVVG
Sbjct: 248 AYILAVVG 255
>NP_940962
          Length = 247

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++A++G
Sbjct: 176 AYILAIIG 183
>NP_945351
          Length = 236

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++A++G
Sbjct: 189 AYILAIIG 196
>XP_005250386
          Length = 232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++A++G
Sbjct: 189 AYILAIIG 196
>XP_005250384
          Length = 232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++A++G
Sbjct: 189 AYILAIIG 196
>NP_005219
          Length = 1210

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAYVMAVV 8
           EAYVMA V
Sbjct: 762 EAYVMASV 769
>XP_005248564
          Length = 2342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAYVMAVV 8
           E YVMAVV
Sbjct: 916 EDYVMAVV 923
>NP_005900
          Length = 2468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    EAYVMAVV 8
            E YVMAVV
Sbjct: 1042 EDYVMAVV 1049
>NP_056494
          Length = 331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   EAYVMAVVG 9
           EAY MAV G
Sbjct: 188 EAYEMAVRG 196
>NP_064593
          Length = 592

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AYVMAVVG 9
           AY +AV+G
Sbjct: 553 AYALAVIG 560
>NP_690621
          Length = 1014

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AV+G
Sbjct: 658 AYIIAVLG 665
>NP_690620
          Length = 940

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AV+G
Sbjct: 584 AYIIAVLG 591
>NP_690619
          Length = 1030

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AV+G
Sbjct: 674 AYIIAVLG 681
>NP_002812
          Length = 1070

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AV+G
Sbjct: 714 AYIIAVLG 721
>NP_001257327
          Length = 1078

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AYVMAVVG 9
           AY++AV+G
Sbjct: 722 AYIIAVLG 729
>NP_071800
          Length = 555

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AYVMAVVG 9
           AY +AV+G
Sbjct: 516 AYALAVIG 523
>NP_789786
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005276824
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005276823
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005276822
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 228 EAYVMA 233
>XP_006726278
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 241 EAYVMA 246
>XP_005276821
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 245 EAYVMA 250
>XP_006726277
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 313 EAYVMA 318
>XP_005276820
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 317 EAYVMA 322
>XP_005276819
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005276818
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005248520
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005248519
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005248518
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 228 EAYVMA 233
>XP_006714633
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 241 EAYVMA 246
>XP_005248517
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 245 EAYVMA 250
>XP_006714632
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 313 EAYVMA 318
>XP_005248516
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 317 EAYVMA 322
>XP_005248515
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005248514
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>NP_001005174
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YVMAVVG 9
          Y++AVVG
Sbjct: 37 YIIAVVG 43
>NP_001005289
          Length = 320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  YVMAVVG 9
          Y++AVVG
Sbjct: 43 YIVAVVG 49
>NP_001191230
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 334 EEYCMAVCG 342
>NP_001129488
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 329 EEYCMAVCG 337
>NP_001191231
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 334 EEYCMAVCG 342
>NP_001129602
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 278 EEYCMAVCG 286
>NP_958816
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 334 EEYCMAVCG 342
>NP_000475
          Length = 770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   EAYVMAVVG 9
           E Y MAV G
Sbjct: 334 EEYCMAVCG 342
>NP_659488
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AYVMAVV 8
           AY+MAV+
Sbjct: 164 AYLMAVI 170
>XP_006717015
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AYVMAVV 8
           AY+MAV+
Sbjct: 164 AYLMAVI 170
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.133    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 314,917
Number of extensions: 513
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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