Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              19     869
XP_005248564                                                           18    1135
NP_005900                                                              18    1135
NP_003550                                                              17    2528
NP_005019                                                              17    2528
XP_006725428                                                           17    2528
XP_006725427                                                           17    2528
XP_006725426                                                           17    2528
XP_006722195                                                           17    2528
XP_006722194                                                           17    2528
XP_006722193                                                           17    2528
XP_006717513                                                           17    2528
NP_002632                                                              16    5631
NP_065206                                                              16    5631
NP_208382                                                              16    5631
NP_001243415                                                           16    7355
NP_001243417                                                           16    7355
NP_004478                                                              16    7355
NP_001243416                                                           16    7355
NP_001276866                                                           16    7355
NP_004439                                                              16    7355
NP_001276865                                                           16    7355
NP_001005862                                                           16    7355
NP_789786                                                              16    7355
XP_005276824                                                           16    7355
XP_005276823                                                           16    7355
XP_005276822                                                           16    7355
XP_006726278                                                           16    7355
XP_005276821                                                           16    7355
XP_006726277                                                           16    7355
XP_005276820                                                           16    7355
XP_005276819                                                           16    7355
XP_005276818                                                           16    7355
XP_005257197                                                           16    7355
XP_006721828                                                           16    7355
XP_005248520                                                           16    7355
XP_005248519                                                           16    7355
XP_005248518                                                           16    7355
XP_006714633                                                           16    7355
XP_005248517                                                           16    7355
XP_006714632                                                           16    7355
XP_005248516                                                           16    7355
XP_005248515                                                           16    7355
XP_005248514                                                           16    7355
XP_006713654                                                           16    7355
XP_006713653                                                           16    7355
XP_005247430                                                           16    7355
XP_005247429                                                           16    7355
XP_006713652                                                           16    7355
XP_006713651                                                           16    7355
XP_006713650                                                           16    7355
XP_005247428                                                           16    7355
XP_006710560                                                           16    7355
XP_006710559                                                           16    7355
XP_006710558                                                           16    7355
XP_006710557                                                           16    7355
XP_006710556                                                           16    7355
XP_006710554                                                           16    7355
XP_005270723                                                           16    7355
XP_006710552                                                           16    7355
XP_006710551                                                           16    7355
XP_006710550                                                           16    7355
XP_006710549                                                           16    7355
XP_006710548                                                           16    7355
NP_000114                                                              15    9605
NP_060003                                                              15    9605
NP_001191354                                                           15    9605
XP_005256707                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAYVMAIVD 9
           EAYVMA VD
Sbjct: 762 EAYVMASVD 770
>XP_005248564
          Length = 2342

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   EAYVMAIVD 9
           E YVMA+VD
Sbjct: 916 EDYVMAVVD 924
>NP_005900
          Length = 2468

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    EAYVMAIVD 9
            E YVMA+VD
Sbjct: 1042 EDYVMAVVD 1050
>NP_003550
          Length = 416

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 361 EVYFMAIID 369
>NP_005019
          Length = 406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 351 EVYFMAIID 359
>XP_006725428
          Length = 257

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 202 EVYFMAIID 210
>XP_006725427
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 297 EVYFMAIID 305
>XP_006725426
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 297 EVYFMAIID 305
>XP_006722195
          Length = 257

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 202 EVYFMAIID 210
>XP_006722194
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 297 EVYFMAIID 305
>XP_006722193
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 297 EVYFMAIID 305
>XP_006717513
          Length = 355

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           E Y MAI+D
Sbjct: 300 EVYFMAIID 308
>NP_002632
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EAYVMAIVD 9
           EA+ MAIV+
Sbjct: 312 EAFCMAIVE 320
>NP_065206
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EAYVMAIVD 9
          EA+ MAIV+
Sbjct: 78 EAFCMAIVE 86
>NP_208382
          Length = 648

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           +AY M I+D
Sbjct: 380 QAYAMKIID 388
>NP_001243415
          Length = 3269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2973 EQYLMAISD 2981
>NP_001243417
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2893 EQYLMAISD 2901
>NP_004478
          Length = 3259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2968 EQYLMAISD 2976
>NP_001243416
          Length = 3225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2934 EQYLMAISD 2942
>NP_001276866
          Length = 1055

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 770 EAYVMA 775
>NP_004439
          Length = 1255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 770 EAYVMA 775
>NP_001276865
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 755 EAYVMA 760
>NP_001005862
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 740 EAYVMA 745
>NP_789786
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005276824
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005276823
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005276822
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 228 EAYVMA 233
>XP_006726278
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 241 EAYVMA 246
>XP_005276821
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 245 EAYVMA 250
>XP_006726277
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 313 EAYVMA 318
>XP_005276820
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 317 EAYVMA 322
>XP_005276819
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005276818
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005257197
          Length = 1225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 740 EAYVMA 745
>XP_006721828
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 851 EAYVMA 856
>XP_005248520
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005248519
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 193 EAYVMA 198
>XP_005248518
          Length = 421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 228 EAYVMA 233
>XP_006714633
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 241 EAYVMA 246
>XP_005248517
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 245 EAYVMA 250
>XP_006714632
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 313 EAYVMA 318
>XP_005248516
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 317 EAYVMA 322
>XP_005248515
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_005248514
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   EAYVMA 6
           EAYVMA
Sbjct: 318 EAYVMA 323
>XP_006713654
          Length = 3189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2893 EQYLMAISD 2901
>XP_006713653
          Length = 3223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2932 EQYLMAISD 2940
>XP_005247430
          Length = 3228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2932 EQYLMAISD 2940
>XP_005247429
          Length = 3230

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2934 EQYLMAISD 2942
>XP_006713652
          Length = 3263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2967 EQYLMAISD 2975
>XP_006713651
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2968 EQYLMAISD 2976
>XP_006713650
          Length = 3264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2973 EQYLMAISD 2981
>XP_005247428
          Length = 3269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            E Y+MAI D
Sbjct: 2973 EQYLMAISD 2981
>XP_006710560
          Length = 1181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710559
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710558
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710557
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710556
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710554
          Length = 1421

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_005270723
          Length = 1459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 604 AYLKAIVD 611
>XP_006710552
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710551
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710550
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710549
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>XP_006710548
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AYVMAIVD 9
           AY+ AIVD
Sbjct: 609 AYLKAIVD 616
>NP_000114
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAYVMAIVD 9
           EAY+  +VD
Sbjct: 934 EAYLKPVVD 942
>NP_060003
          Length = 1939

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EAYVMAIV 8
          E+YV AIV
Sbjct: 45 ESYVKAIV 52
>NP_001191354
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    EAYVMAIVD 9
            EAY+  +VD
Sbjct: 1388 EAYLKPVVD 1396
>XP_005256707
          Length = 1940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EAYVMAIV 8
          E+YV AIV
Sbjct: 45 ESYVKAIV 52
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.135    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 316,743
Number of extensions: 509
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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