Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     390
NP_001087241                                                           20     390
XP_005265799                                                           20     390
XP_005265798                                                           20     390
XP_005265797                                                           20     390
NP_004110                                                              18    1135
NP_078930                                                              17    2528
XP_006710230                                                           17    2528
NP_005202                                                              17    3301
NP_001275634                                                           17    3301
NP_940867                                                              17    3301
XP_006724697                                                           17    3301
XP_006724696                                                           17    3301
XP_006724695                                                           17    3301
XP_006724694                                                           17    3301
NP_938056                                                              17    4312
NP_001243543                                                           17    4312
NP_938055                                                              17    4312
NP_001243542                                                           17    4312
NP_060392                                                              17    4312
NP_872395                                                              17    4312
XP_005247433                                                           17    4312
NP_000634                                                              16    5631
NP_000635                                                              16    5631
NP_000636                                                              16    5631
NP_000019                                                              16    5631
NP_000637                                                              16    5631
NP_000633                                                              16    5631
NP_037361                                                              16    5631
NP_780775                                                              16    5631
NP_001230199                                                           16    5631
NP_055176                                                              16    5631
NP_863651                                                              16    5631
NP_001151                                                              16    5631
NP_863659                                                              16    5631
NP_863658                                                              16    5631
NP_001230200                                                           16    5631
XP_005270614                                                           16    5631
NP_073591                                                              16    5631
NP_001243398                                                           16    7355
NP_036462                                                              16    7355
NP_001243397                                                           16    7355
NP_001008777                                                           16    7355
NP_001316                                                              16    7355
NP_115604                                                              16    7355
NP_001164638                                                           16    7355
NP_598376                                                              16    7355
XP_005269721                                                           16    7355
NP_056050                                                              16    7355
NP_000042                                                              15    9605
NP_002011                                                              15    9605
NP_002323                                                              15    9605
NP_004786                                                              15    9605
NP_891555                                                              15    9605
NP_002244                                                              15    9605
NP_001158238                                                           15    9605
NP_002010                                                              15    9605
NP_207646                                                              15    9605
NP_078997                                                              15    9605
NP_008816                                                              15    9605
XP_005256014                                                           15    9605
XP_006720345                                                           15    9605
XP_005268192                                                           15    9605
XP_005268191                                                           15    9605
XP_006718908                                                           15    9605
XP_005271621                                                           15    9605
XP_006718907                                                           15    9605
XP_006718906                                                           15    9605
XP_005271619                                                           15    9605
XP_005271618                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARNILLTH
Sbjct: 795 ARNILLTH 802
>NP_001087241
          Length = 972

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARNILLTH
Sbjct: 791 ARNILLTH 798
>XP_005265799
          Length = 973

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARNILLTH
Sbjct: 792 ARNILLTH 799
>XP_005265798
          Length = 976

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARNILLTH
Sbjct: 795 ARNILLTH 802
>XP_005265797
          Length = 977

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARNILLTH
Sbjct: 796 ARNILLTH 803
>NP_004110
          Length = 993

 Score = 18.5 bits (36), Expect =  1135
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARN+L+TH
Sbjct: 814 ARNVLVTH 821
>NP_078930
          Length = 702

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           EARN+L +H
Sbjct: 194 EARNLLKSH 202
>XP_006710230
          Length = 332

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   RNILLTH 9
           RNI+LTH
Sbjct: 136 RNIVLTH 142
>NP_005202
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARN+LLT+
Sbjct: 781 ARNVLLTN 788
>NP_001275634
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ARNILLTH 9
           ARN+LLT+
Sbjct: 781 ARNVLLTN 788
>NP_940867
          Length = 1582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           + +N+LLTH
Sbjct: 179 KGQNVLLTH 187
>XP_006724697
          Length = 1526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           + +N+LLTH
Sbjct: 179 KGQNVLLTH 187
>XP_006724696
          Length = 1534

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           + +N+LLTH
Sbjct: 179 KGQNVLLTH 187
>XP_006724695
          Length = 1574

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           + +N+LLTH
Sbjct: 179 KGQNVLLTH 187
>XP_006724694
          Length = 1582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           + +N+LLTH
Sbjct: 179 KGQNVLLTH 187
>NP_938056
          Length = 456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 205 SRNILQTH 212
>NP_001243543
          Length = 482

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 231 SRNILQTH 238
>NP_938055
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 190 SRNILQTH 197
>NP_001243542
          Length = 456

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 205 SRNILQTH 212
>NP_060392
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EARNILLT 8
           EARNIL T
Sbjct: 439 EARNILKT 446
>NP_872395
          Length = 471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 220 SRNILQTH 227
>XP_005247433
          Length = 374

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   ARNILLTH 9
           +RNIL TH
Sbjct: 134 SRNILQTH 141
>NP_000634
          Length = 1532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1119 EARNIIL 1125
>NP_000635
          Length = 1532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1119 EARNIIL 1125
>NP_000636
          Length = 1515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1102 EARNIIL 1108
>NP_000019
          Length = 1532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1119 EARNIIL 1125
>NP_000637
          Length = 1516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1103 EARNIIL 1109
>NP_000633
          Length = 1532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1119 EARNIIL 1125
>NP_037361
          Length = 1237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EARNILLTH 9
          +ARN LL H
Sbjct: 4  KARNCLLQH 12
>NP_780775
          Length = 1026

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RNILL H
Sbjct: 564 RNILLMH 570
>NP_001230199
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RNILL H
Sbjct: 638 RNILLMH 644
>NP_055176
          Length = 1100

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RNILL H
Sbjct: 638 RNILLMH 644
>NP_863651
          Length = 1248

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EARNILLTH 9
          +ARN LL H
Sbjct: 4  KARNCLLQH 12
>NP_001151
          Length = 1194

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EARNILLTH 9
          +ARN LL H
Sbjct: 4  KARNCLLQH 12
>NP_863659
          Length = 338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EARNILLTH 9
          +ARN LL H
Sbjct: 4  KARNCLLQH 12
>NP_863658
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  EARNILLTH 9
          +ARN LL H
Sbjct: 4  KARNCLLQH 12
>NP_001230200
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RNILL H
Sbjct: 638 RNILLMH 644
>XP_005270614
          Length = 1532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    EARNILL 7
            EARNI+L
Sbjct: 1119 EARNIIL 1125
>NP_073591
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  EARNILLTH 9
          + RNILLT+
Sbjct: 33 DPRNILLTN 41
>NP_001243398
          Length = 1781

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           +++NILL H
Sbjct: 467 KSKNILLRH 475
>NP_036462
          Length = 2073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           +++NILL H
Sbjct: 759 KSKNILLRH 767
>NP_001243397
          Length = 1890

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           +++NILL H
Sbjct: 576 KSKNILLRH 584
>NP_001008777
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RN+LL H
Sbjct: 220 RNVLLDH 226
>NP_001316
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EARNILL 7
           EARN+LL
Sbjct: 157 EARNMLL 163
>NP_115604
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EARNILLT 8
          E +N+LLT
Sbjct: 9  EGKNVLLT 16
>NP_001164638
          Length = 1241

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    ARNILLTH 9
            ARN LL+H
Sbjct: 1177 ARNKLLSH 1184
>NP_598376
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           +AR +++TH
Sbjct: 316 DARKVVVTH 324
>XP_005269721
          Length = 2073

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EARNILLTH 9
           +++NILL H
Sbjct: 759 KSKNILLRH 767
>NP_056050
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   EARNILL 7
           EARN+LL
Sbjct: 157 EARNMLL 163
>NP_000042
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1859 RNLLSTH 1865
>NP_002011
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ARNILLT 8
            ARNILL+
Sbjct: 1040 ARNILLS 1046
>NP_002323
          Length = 4544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    ARNILLTH 9
            ARN + TH
Sbjct: 3850 ARNFMKTH 3857
>NP_004786
          Length = 1012

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   ARNILLTH 9
           A N+LL H
Sbjct: 268 AHNLLLAH 275
>NP_891555
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ARNILLT 8
            ARNILL+
Sbjct: 1040 ARNILLS 1046
>NP_002244
          Length = 1356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ARNILLT 8
            ARNILL+
Sbjct: 1031 ARNILLS 1037
>NP_001158238
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           +NILL H
Sbjct: 643 KNILLVH 649
>NP_002010
          Length = 1338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    ARNILLT 8
            ARNILL+
Sbjct: 1025 ARNILLS 1031
>NP_207646
          Length = 2572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            +NILL H
Sbjct: 1203 KNILLVH 1209
>NP_078997
          Length = 3616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            +NILL H
Sbjct: 1553 KNILLVH 1559
>NP_008816
          Length = 3703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            +NILL H
Sbjct: 1557 KNILLVH 1563
>XP_005256014
          Length = 3702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            +NILL H
Sbjct: 1556 KNILLVH 1562
>XP_006720345
          Length = 1522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           +NILL H
Sbjct: 153 KNILLVH 159
>XP_005268192
          Length = 1602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           +NILL H
Sbjct: 233 KNILLVH 239
>XP_005268191
          Length = 2572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            +NILL H
Sbjct: 1203 KNILLVH 1209
>XP_006718908
          Length = 1708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RNILLTH 9
           RN+L TH
Sbjct: 511 RNLLSTH 517
>XP_005271621
          Length = 2708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1511 RNLLSTH 1517
>XP_006718907
          Length = 3050

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1853 RNLLSTH 1859
>XP_006718906
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1859 RNLLSTH 1865
>XP_005271619
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1859 RNLLSTH 1865
>XP_005271618
          Length = 3056

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    RNILLTH 9
            RN+L TH
Sbjct: 1859 RNLLSTH 1865
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.135    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 453,023
Number of extensions: 906
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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