Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              20     299
NP_742068                                                              17    3301
XP_006711246                                                           17    3301
XP_005244978                                                           17    3301
XP_005244977                                                           17    3301
XP_005244976                                                           17    3301
XP_005244975                                                           17    3301
NP_071766                                                              17    4312
XP_006711548                                                           17    4312
NP_006166                                                              16    5631
NP_001248392                                                           16    5631
NP_932326                                                              16    5631
NP_776152                                                              16    5631
NP_001014977                                                           16    5631
XP_005260725                                                           16    5631
XP_005269924                                                           16    5631
XP_005269922                                                           16    5631
XP_006717933                                                           16    5631
XP_005269921                                                           16    5631
XP_005269575                                                           16    5631
XP_005263960                                                           16    5631
XP_005263959                                                           16    5631
NP_848572                                                              16    5631
NP_001152967                                                           16    5631
NP_000247                                                              16    7355
NP_071942                                                              16    7355
NP_775735                                                              16    7355
XP_006722426                                                           16    7355
XP_006722425                                                           16    7355
XP_005258223                                                           16    7355
XP_006718301                                                           16    7355
NP_006006                                                              15    9605
NP_054706                                                              15    9605
NP_003364                                                              15    9605
NP_624361                                                              15    9605
NP_001424                                                              15    9605
NP_002449                                                              15    9605
NP_073620                                                              15    9605
NP_001230178                                                           15    9605
NP_001269941                                                           15    9605
NP_001230176                                                           15    9605
NP_001034565                                                           15    9605
NP_001127911                                                           15    9605
NP_001127910                                                           15    9605
NP_665696                                                              15    9605
NP_001035059                                                           15    9605
NP_001265168                                                           15    9605
NP_001265165                                                           15    9605
NP_002888                                                              15    9605
NP_058520                                                              15    9605
NP_116170                                                              15    9605
NP_008837                                                              15    9605
NP_001070818                                                           15    9605
NP_001230177                                                           15    9605
NP_001265167                                                           15    9605
XP_006721832                                                           15    9605
XP_005270200                                                           15    9605
XP_005270199                                                           15    9605
XP_006712738                                                           15    9605
XP_006712737                                                           15    9605
XP_006712736                                                           15    9605
XP_005246797                                                           15    9605
XP_005246798                                                           15    9605
XP_005246796                                                           15    9605
XP_006712735                                                           15    9605
XP_005246795                                                           15    9605
XP_005246794                                                           15    9605
XP_006712734                                                           15    9605
NP_001127909                                                           15    9605
>NP_004251
          Length = 1208

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EAQQLSHQA 9
           EA+QLSHQA
Sbjct: 881 EAEQLSHQA 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QQLSHQA 9
           +QL HQA
Sbjct: 474 EQLGHQA 480
>NP_742068
          Length = 1133

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 969 ELQQLNHQ 976
>XP_006711246
          Length = 1101

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 969 ELQQLNHQ 976
>XP_005244978
          Length = 1113

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 948 ELQQLNHQ 955
>XP_005244977
          Length = 1124

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 969 ELQQLNHQ 976
>XP_005244976
          Length = 1125

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 969 ELQQLNHQ 976
>XP_005244975
          Length = 1134

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           E QQL+HQ
Sbjct: 969 ELQQLNHQ 976
>NP_071766
          Length = 397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   EAQQLSHQ 8
           E QQL HQ
Sbjct: 222 ETQQLCHQ 229
>XP_006711548
          Length = 181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  EAQQLSHQ 8
          E QQL HQ
Sbjct: 6  ETQQLCHQ 13
>NP_006166
          Length = 1695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 469 AQQLSH 474
>NP_001248392
          Length = 1731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 504 AQQLSH 509
>NP_932326
          Length = 1730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 504 AQQLSH 509
>NP_776152
          Length = 1154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EAQQLSH 7
           EAQ LSH
Sbjct: 514 EAQSLSH 520
>NP_001014977
          Length = 90

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  EAQQLSH 7
          EAQQ SH
Sbjct: 74 EAQQTSH 80
>XP_005260725
          Length = 90

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  EAQQLSH 7
          EAQQ SH
Sbjct: 74 EAQQTSH 80
>XP_005269924
          Length = 1627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 504 AQQLSH 509
>XP_005269922
          Length = 1695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 504 AQQLSH 509
>XP_006717933
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 504 AQQLSH 509
>XP_005269921
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQLSH
Sbjct: 469 AQQLSH 474
>XP_005269575
          Length = 1113

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   EAQQLSH 7
           EAQ LSH
Sbjct: 473 EAQSLSH 479
>XP_005263960
          Length = 372

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EAQQLSHQ 8
          EA+ LSHQ
Sbjct: 54 EAEGLSHQ 61
>XP_005263959
          Length = 389

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  EAQQLSHQ 8
          EA+ LSHQ
Sbjct: 54 EAEGLSHQ 61
>NP_848572
          Length = 90

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  EAQQLSH 7
          EAQQ SH
Sbjct: 74 EAQQTSH 80
>NP_001152967
          Length = 97

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  EAQQLSH 7
          EAQQ SH
Sbjct: 81 EAQQTSH 87
>NP_000247
          Length = 1274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           Q+LSH+A
Sbjct: 827 QELSHEA 833
>NP_071942
          Length = 173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   EAQQLSHQA 9
           E +QLSH A
Sbjct: 119 EKKQLSHPA 127
>NP_775735
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAQQLSHQA 9
           +AQQ+ HQ+
Sbjct: 496 QAQQVLHQS 504
>XP_006722426
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAQQLSHQA 9
           +AQQ+ HQ+
Sbjct: 400 QAQQVLHQS 408
>XP_006722425
          Length = 593

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAQQLSHQA 9
           +AQQ+ HQ+
Sbjct: 487 QAQQVLHQS 495
>XP_005258223
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAQQLSHQA 9
           +AQQ+ HQ+
Sbjct: 487 QAQQVLHQS 495
>XP_006718301
          Length = 1268

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           Q+LSH+A
Sbjct: 821 QELSHEA 827
>NP_006006
          Length = 2285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AQQLSHQA 9
           AQQ SH A
Sbjct: 353 AQQRSHHA 360
>NP_054706
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AQQLSH 7
          AQQ+SH
Sbjct: 17 AQQISH 22
>NP_003364
          Length = 1066

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AQQLSH 7
          AQQ+SH
Sbjct: 17 AQQISH 22
>NP_624361
          Length = 2068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AQQLSHQA 9
           AQQ SH A
Sbjct: 353 AQQRSHHA 360
>NP_001424
          Length = 977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EAQQLSHQ 8
           + QQL HQ
Sbjct: 470 QQQQLQHQ 477
>NP_002449
          Length = 5762

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    EAQQLSHQ 8
            EAQ + HQ
Sbjct: 5694 EAQAMQHQ 5701
>NP_073620
          Length = 409

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   EAQQLSHQ 8
           EA+QL H+
Sbjct: 185 EAEQLCHR 192
>NP_001230178
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AQQLSHQ 8
           A+Q SHQ
Sbjct: 324 AEQFSHQ 330
>NP_001269941
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  EAQQLSHQ 8
          EA+QL H+
Sbjct: 84 EAEQLCHR 91
>NP_001230176
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AQQLSHQ 8
           A+Q SHQ
Sbjct: 271 AEQFSHQ 277
>NP_001034565
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AQQLSHQ 8
           A+Q SHQ
Sbjct: 170 AEQFSHQ 176
>NP_001127911
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAQQLSHQA 9
           E QQL H++
Sbjct: 726 EFQQLEHES 734
>NP_001127910
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAQQLSHQA 9
           E QQL H++
Sbjct: 726 EFQQLEHES 734
>NP_665696
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAQQLSHQA 9
           E QQL H++
Sbjct: 683 EFQQLEHES 691
>NP_001035059
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 525 KQLSHQS 531
>NP_001265168
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 501 KQLSHQS 507
>NP_001265165
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 525 KQLSHQS 531
>NP_002888
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 338 AQQMSH 343
>NP_058520
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 341 AQQMSH 346
>NP_116170
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 557 KQLSHQS 563
>NP_008837
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 557 KQLSHQS 563
>NP_001070818
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AQQLSHQ 8
           A+Q SHQ
Sbjct: 349 AEQFSHQ 355
>NP_001230177
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AQQLSHQ 8
           A+Q SHQ
Sbjct: 324 AEQFSHQ 330
>NP_001265167
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QQLSHQA 9
           +QLSHQ+
Sbjct: 533 KQLSHQS 539
>XP_006721832
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   EAQQLSHQ 8
           + QQL HQ
Sbjct: 585 QQQQLQHQ 592
>XP_005270200
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AQQLSH 7
          AQQ+SH
Sbjct: 17 AQQISH 22
>XP_005270199
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  AQQLSH 7
          AQQ+SH
Sbjct: 17 AQQISH 22
>XP_006712738
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 338 AQQMSH 343
>XP_006712737
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 340 AQQMSH 345
>XP_006712736
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 343 AQQMSH 348
>XP_005246797
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 354 AQQMSH 359
>XP_005246798
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 354 AQQMSH 359
>XP_005246796
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 355 AQQMSH 360
>XP_006712735
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 356 AQQMSH 361
>XP_005246795
          Length = 421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 356 AQQMSH 361
>XP_005246794
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 357 AQQMSH 362
>XP_006712734
          Length = 424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AQQLSH 7
           AQQ+SH
Sbjct: 359 AQQMSH 364
>NP_001127909
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAQQLSHQA 9
           E QQL H++
Sbjct: 710 EFQQLEHES 718
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.299    0.103    0.250 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 608,658
Number of extensions: 1135
Number of successful extensions: 70
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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