Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              18    1935
XP_005248577                                                           18    1935
XP_005248576                                                           18    1935
NP_599023                                                              16    5631
NP_599022                                                              16    5631
NP_599024                                                              16    5631
NP_002934                                                              16    5631
NP_005051                                                              16    5631
NP_001001523                                                           16    5631
XP_005254641                                                           16    5631
XP_005245481                                                           16    5631
XP_006711547                                                           16    5631
NP_001193865                                                           16    7355
NP_001193895                                                           16    7355
NP_001193858                                                           16    7355
NP_001193869                                                           16    7355
NP_001193861                                                           16    7355
NP_001193883                                                           16    7355
NP_001193863                                                           16    7355
NP_001127                                                              16    7355
NP_751947                                                              16    7355
NP_055529                                                              16    7355
NP_060334                                                              16    7355
XP_006721055                                                           16    7355
XP_006721054                                                           16    7355
XP_006721053                                                           16    7355
XP_006721052                                                           16    7355
XP_006716666                                                           16    7355
XP_006716665                                                           16    7355
NP_001167579                                                           16    7355
NP_055213                                                              15    9605
NP_006608                                                              15    9605
NP_056121                                                              15    9605
NP_001264671                                                           15    9605
NP_063938                                                              15    9605
XP_006713649                                                           15    9605
XP_005247417                                                           15    9605
XP_005264490                                                           15    9605
XP_005270747                                                           15    9605
XP_006710574                                                           15    9605
XP_005270746                                                           15    9605
>NP_005912
          Length = 1512

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAIQLVVED 9
           EAIQL VED
Sbjct: 867 EAIQLGVED 875
>XP_005248577
          Length = 1349

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAIQLVVED 9
           EAIQL VED
Sbjct: 704 EAIQLGVED 712
>XP_005248576
          Length = 1375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   EAIQLVVED 9
           EAIQL VED
Sbjct: 730 EAIQLGVED 738
>NP_599023
          Length = 523

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 329 EAIQYVVE 336
>NP_599022
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 362 EAIQYVVE 369
>NP_599024
          Length = 468

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 274 EAIQYVVE 281
>NP_002934
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 354 EAIQYVVE 361
>NP_005051
          Length = 518

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 326 EAIQYVVE 333
>NP_001001523
          Length = 497

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 305 EAIQYVVE 312
>XP_005254641
          Length = 477

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 283 EAIQYVVE 290
>XP_005245481
          Length = 512

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 320 EAIQYVVE 327
>XP_006711547
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           EAIQ VVE
Sbjct: 380 EAIQYVVE 387
>NP_001193865
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 236 EEVQLVVE 243
>NP_001193895
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 236 EEVQLVVE 243
>NP_001193858
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 252 EEVQLVVE 259
>NP_001193869
          Length = 347

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 236 EEVQLVVE 243
>NP_001193861
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 222 EEVQLVVE 229
>NP_001193883
          Length = 325

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 236 EEVQLVVE 243
>NP_001193863
          Length = 363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 252 EEVQLVVE 259
>NP_001127
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 236 EEVQLVVE 243
>NP_751947
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAIQLVVE 8
           E +QLVVE
Sbjct: 222 EEVQLVVE 229
>NP_055529
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQLVVED 9
            A+QL+ ED
Sbjct: 1109 ALQLIAED 1116
>NP_060334
          Length = 995

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAIQLVVED 9
           E IQ+ +ED
Sbjct: 340 EVIQIFIED 348
>XP_006721055
          Length = 673

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIQLVVED 9
           A+QL+ ED
Sbjct: 320 ALQLIAED 327
>XP_006721054
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQLVVED 9
            A+QL+ ED
Sbjct: 1109 ALQLIAED 1116
>XP_006721053
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQLVVED 9
            A+QL+ ED
Sbjct: 1109 ALQLIAED 1116
>XP_006721052
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    AIQLVVED 9
            A+QL+ ED
Sbjct: 1109 ALQLIAED 1116
>XP_006716666
          Length = 886

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAIQLVVED 9
           E IQ+ +ED
Sbjct: 231 EVIQIFIED 239
>XP_006716665
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   EAIQLVVED 9
           E IQ+ +ED
Sbjct: 288 EVIQIFIED 296
>NP_001167579
          Length = 979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQ++VED
Sbjct: 415 IQMIVED 421
>NP_055213
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQL+V+D
Sbjct: 244 IQLIVQD 250
>NP_006608
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    EAIQLVVED 9
            EAI+ +VED
Sbjct: 1061 EAIEPLVED 1069
>NP_056121
          Length = 2620

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EAIQLVV 7
           EAIQL++
Sbjct: 841 EAIQLII 847
>NP_001264671
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IQLVVED 9
          IQLV++D
Sbjct: 86 IQLVIQD 92
>NP_063938
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQLV++D
Sbjct: 161 IQLVIQD 167
>XP_006713649
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQL+V+D
Sbjct: 220 IQLIVQD 226
>XP_005247417
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQL+V+D
Sbjct: 244 IQLIVQD 250
>XP_005264490
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IQLVVED 9
           IQLV++D
Sbjct: 103 IQLVIQD 109
>XP_005270747
          Length = 2025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EAIQLVV 7
           EAIQL++
Sbjct: 246 EAIQLII 252
>XP_006710574
          Length = 2445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EAIQLVV 7
           EAIQL++
Sbjct: 666 EAIQLII 672
>XP_005270746
          Length = 2443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   EAIQLVV 7
           EAIQL++
Sbjct: 666 EAIQLII 672
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.134    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 354,204
Number of extensions: 649
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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