Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004295                                                              20     509
NP_001909                                                              18    1935
XP_005270603                                                           18    1935
XP_005270602                                                           18    1935
NP_001252541                                                           17    4312
NP_057368                                                              17    4312
NP_006827                                                              17    4312
NP_036602                                                              16    7355
NP_006421                                                              16    7355
NP_000688                                                              16    7355
NP_001243650                                                           16    7355
NP_003777                                                              16    7355
NP_057595                                                              16    7355
NP_009194                                                              16    7355
NP_114416                                                              16    7355
NP_955474                                                              16    7355
XP_005257820                                                           16    7355
XP_006715974                                                           16    7355
NP_115514                                                              16    7355
NP_690867                                                              16    7355
NP_004949                                                              15    9605
NP_997320                                                              15    9605
NP_861441                                                              15    9605
NP_612364                                                              15    9605
NP_001239200                                                           15    9605
NP_001138495                                                           15    9605
NP_689923                                                              15    9605
NP_001006606                                                           15    9605
NP_689634                                                              15    9605
NP_001239199                                                           15    9605
NP_001239198                                                           15    9605
XP_005257833                                                           15    9605
XP_006722227                                                           15    9605
XP_005253612                                                           15    9605
XP_006717764                                                           15    9605
XP_006717763                                                           15    9605
XP_006717762                                                           15    9605
XP_005269673                                                           15    9605
XP_005269672                                                           15    9605
XP_006717761                                                           15    9605
XP_006717760                                                           15    9605
XP_006717759                                                           15    9605
XP_006717017                                                           15    9605
XP_005268434                                                           15    9605
XP_006714819                                                           15    9605
XP_005263496                                                           15    9605
XP_005263495                                                           15    9605
>NP_004295
          Length = 1620

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   EAALGLLQF 9
           EAA+GLLQF
Sbjct: 160 EAAVGLLQF 168
>NP_001909
          Length = 482

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   AALGLLQF 9
           A+LGLLQF
Sbjct: 315 ASLGLLQF 322
>XP_005270603
          Length = 301

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   AALGLLQF 9
           A+LGLLQF
Sbjct: 134 ASLGLLQF 141
>XP_005270602
          Length = 301

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   AALGLLQF 9
           A+LGLLQF
Sbjct: 134 ASLGLLQF 141
>NP_001252541
          Length = 2371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    AALGLLQ 8
            AALGLLQ
Sbjct: 1652 AALGLLQ 1658
>NP_057368
          Length = 2376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2    AALGLLQ 8
            AALGLLQ
Sbjct: 1657 AALGLLQ 1663
>NP_006827
          Length = 2671

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   EAALGLL 7
           EAALGLL
Sbjct: 856 EAALGLL 862
>NP_036602
          Length = 923

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           EAA+GLL+
Sbjct: 556 EAAVGLLK 563
>NP_006421
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAALGLLQF 9
           +A +GL+QF
Sbjct: 243 KAKIGLIQF 251
>NP_000688
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  LGLLQF 9
          LGLLQF
Sbjct: 57 LGLLQF 62
>NP_001243650
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   EAALGLLQF 9
           +A +GL+QF
Sbjct: 213 KAKIGLIQF 221
>NP_003777
          Length = 1527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    AALGLLQ 8
            AALG+LQ
Sbjct: 1016 AALGILQ 1022
>NP_057595
          Length = 280

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2  AALGLLQF 9
          AALGLL F
Sbjct: 66 AALGLLFF 73
>NP_009194
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           EAA GLLQ
Sbjct: 233 EAAEGLLQ 240
>NP_114416
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           ALGLL+F
Sbjct: 145 ALGLLKF 151
>NP_955474
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           EAA GLLQ
Sbjct: 182 EAAEGLLQ 189
>XP_005257820
          Length = 1463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   AALGLLQ 8
           AALG+LQ
Sbjct: 952 AALGILQ 958
>XP_006715974
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           EAA+GLL+
Sbjct: 508 EAAVGLLK 515
>NP_115514
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLLQF 9
           LGLLQF
Sbjct: 602 LGLLQF 607
>NP_690867
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LGLLQF 9
           LGLLQF
Sbjct: 602 LGLLQF 607
>NP_004949
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EAALGLLQF 9
            EAA G+L++
Sbjct: 1427 EAAAGVLEY 1435
>NP_997320
          Length = 4471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EAALGLLQF 9
            +A LG+L+F
Sbjct: 3232 KAGLGMLKF 3240
>NP_861441
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AALGLLQF 9
           AALG L+F
Sbjct: 314 AALGYLRF 321
>NP_612364
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           +AALGL++
Sbjct: 363 QAALGLME 370
>NP_001239200
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 247 AIGLLEF 253
>NP_001138495
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           +AALGL++
Sbjct: 363 QAALGLME 370
>NP_689923
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 260 DLALGLLQ 267
>NP_001006606
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 272 AIGLLEF 278
>NP_689634
          Length = 431

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 275 AIGLLEF 281
>NP_001239199
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 213 AIGLLEF 219
>NP_001239198
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 227 AIGLLEF 233
>XP_005257833
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           +AALGL++
Sbjct: 363 QAALGLME 370
>XP_006722227
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   EAALGLLQ 8
           +AALGL++
Sbjct: 371 QAALGLME 378
>XP_005253612
          Length = 4589

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EAALGLLQF 9
            +A LG+L+F
Sbjct: 3350 KAGLGMLKF 3358
>XP_006717764
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 140 DLALGLLQ 147
>XP_006717763
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 172 DLALGLLQ 179
>XP_006717762
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 173 DLALGLLQ 180
>XP_005269673
          Length = 350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 259 DLALGLLQ 266
>XP_005269672
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 260 DLALGLLQ 267
>XP_006717761
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 292 DLALGLLQ 299
>XP_006717760
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 259 DLALGLLQ 266
>XP_006717759
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   EAALGLLQ 8
           + ALGLLQ
Sbjct: 291 DLALGLLQ 298
>XP_006717017
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ALGLLQF 9
           A+GLL+F
Sbjct: 278 AIGLLEF 284
>XP_005268434
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AALGLLQF 9
           AALG L+F
Sbjct: 314 AALGYLRF 321
>XP_006714819
          Length = 450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AALGLLQF 9
           AALG L+F
Sbjct: 281 AALGYLRF 288
>XP_005263496
          Length = 2322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EAALGLLQF 9
            EAA G+L++
Sbjct: 1200 EAAAGVLEY 1208
>XP_005263495
          Length = 2549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    EAALGLLQF 9
            EAA G+L++
Sbjct: 1427 EAAAGVLEY 1435
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.145    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 403,858
Number of extensions: 457
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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