Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              20     390
NP_066124                                                              20     390
XP_006717999                                                           20     390
XP_006722091                                                           17    2528
XP_006722090                                                           17    2528
XP_006722089                                                           17    2528
XP_006722088                                                           17    2528
XP_006722087                                                           17    2528
XP_006722086                                                           17    2528
NP_003101                                                              17    2528
NP_001139395                                                           16    5631
NP_065894                                                              16    5631
XP_005254476                                                           16    5631
XP_005254474                                                           16    5631
NP_001004326                                                           16    7355
NP_001157968                                                           16    7355
XP_005274066                                                           16    7355
XP_006718150                                                           16    7355
XP_006713762                                                           16    7355
XP_006713760                                                           16    7355
XP_006713759                                                           16    7355
NP_060808                                                              16    7355
NP_001138390                                                           15    9605
NP_001138386                                                           15    9605
NP_001138387                                                           15    9605
NP_000132                                                              15    9605
NP_075259                                                              15    9605
NP_001138388                                                           15    9605
NP_001138391                                                           15    9605
NP_001138385                                                           15    9605
NP_075418                                                              15    9605
XP_006717776                                                           15    9605
XP_006717775                                                           15    9605
XP_006717774                                                           15    9605
XP_006717773                                                           15    9605
XP_006717772                                                           15    9605
XP_006717771                                                           15    9605
NP_001092006                                                           15    9605
NP_003472                                                              15    9605
>NP_065681
          Length = 1072

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DYLELAAST 9
            DYL+LAAST
Sbjct: 1014 DYLDLAAST 1022
>NP_066124
          Length = 1114

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DYLELAAST 9
            DYL+LAAST
Sbjct: 1014 DYLDLAAST 1022
>XP_006717999
          Length = 1207

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DYLELAAST 9
            DYL+LAAST
Sbjct: 1107 DYLDLAAST 1115
>XP_006722091
          Length = 656

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 18 DYLQPAAST 26
>XP_006722090
          Length = 660

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 11 DYLQPAAST 19
>XP_006722089
          Length = 660

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 11 DYLQPAAST 19
>XP_006722088
          Length = 660

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 11 DYLQPAAST 19
>XP_006722087
          Length = 664

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 18 DYLQPAAST 26
>XP_006722086
          Length = 667

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 18 DYLQPAAST 26
>NP_003101
          Length = 613

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DYLELAAST 9
          DYL+ AAST
Sbjct: 18 DYLQPAAST 26
>NP_001139395
          Length = 1154

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    DYLELA 6
            DYLELA
Sbjct: 1128 DYLELA 1133
>NP_065894
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    DYLELA 6
            DYLELA
Sbjct: 1374 DYLELA 1379
>XP_005254476
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    DYLELA 6
            DYLELA
Sbjct: 1374 DYLELA 1379
>XP_005254474
          Length = 1406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    DYLELA 6
            DYLELA
Sbjct: 1380 DYLELA 1385
>NP_001004326
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YLELAAS 8
           YL+LAAS
Sbjct: 173 YLQLAAS 179
>NP_001157968
          Length = 1854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DYLELAA 7
           DY+ELA+
Sbjct: 112 DYMELAS 118
>XP_005274066
          Length = 349

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   YLELAAS 8
           YL+LAAS
Sbjct: 173 YLQLAAS 179
>XP_006718150
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   YLELAAST 9
           YLELA +T
Sbjct: 600 YLELAQTT 607
>XP_006713762
          Length = 1197

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DYLELAA 7
           DY+ELA+
Sbjct: 156 DYMELAS 162
>XP_006713760
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DYLELAA 7
           DY+ELA+
Sbjct: 105 DYMELAS 111
>XP_006713759
          Length = 1898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DYLELAA 7
           DY+ELA+
Sbjct: 156 DYMELAS 162
>NP_060808
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DYLELAA 7
           DY+ELA+
Sbjct: 112 DYMELAS 118
>NP_001138390
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 259 DYLEIA 264
>NP_001138386
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 262 DYLEIA 267
>NP_001138387
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 285 DYLEIA 290
>NP_000132
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 374 DYLEIA 379
>NP_075259
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 375 DYLEIA 380
>NP_001138388
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 259 DYLEIA 264
>NP_001138391
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 286 DYLEIA 291
>NP_001138385
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 375 DYLEIA 380
>NP_075418
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 285 DYLEIA 290
>XP_006717776
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 393 DYLEIA 398
>XP_006717775
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 279 DYLEIA 284
>XP_006717774
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 305 DYLEIA 310
>XP_006717773
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 394 DYLEIA 399
>XP_006717772
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 393 DYLEIA 398
>XP_006717771
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 394 DYLEIA 399
>NP_001092006
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 127 DYLEIA 132
>NP_003472
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DYLELA 6
           DYLE+A
Sbjct: 127 DYLEIA 132
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.306    0.120    0.301 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 386,106
Number of extensions: 471
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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