Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     299
NP_001087241                                                           20     299
XP_005265799                                                           20     299
XP_005265798                                                           20     299
XP_005265797                                                           20     299
NP_055478                                                              17    2528
XP_005271413                                                           17    2528
XP_005271412                                                           17    2528
XP_005271411                                                           17    2528
XP_005250863                                                           17    4312
NP_659400                                                              17    4312
NP_789792                                                              16    5631
XP_006718281                                                           16    5631
NP_001138390                                                           16    7355
NP_065169                                                              16    7355
NP_001138386                                                           16    7355
NP_001138387                                                           16    7355
NP_000132                                                              16    7355
NP_075259                                                              16    7355
NP_001138388                                                           16    7355
NP_001138391                                                           16    7355
NP_001138385                                                           16    7355
NP_075418                                                              16    7355
NP_001273680                                                           16    7355
NP_055899                                                              16    7355
NP_001020279                                                           16    7355
NP_079212                                                              16    7355
NP_002276                                                              16    7355
NP_060371                                                              16    7355
NP_001273677                                                           16    7355
NP_061743                                                              16    7355
NP_114476                                                              16    7355
XP_006723898                                                           16    7355
XP_006723897                                                           16    7355
XP_005260524                                                           16    7355
XP_006719528                                                           16    7355
XP_005253963                                                           16    7355
XP_005253962                                                           16    7355
XP_006717776                                                           16    7355
XP_006717775                                                           16    7355
XP_006717774                                                           16    7355
XP_006717773                                                           16    7355
XP_006717772                                                           16    7355
XP_006717771                                                           16    7355
XP_005248213                                                           16    7355
XP_005248212                                                           16    7355
XP_005264002                                                           16    7355
XP_005264000                                                           16    7355
XP_006712586                                                           16    7355
XP_005263999                                                           16    7355
NP_001137291                                                           16    7355
NP_000775                                                              15    9605
NP_003375                                                              15    9605
NP_005236                                                              15    9605
NP_115901                                                              15    9605
NP_001406                                                              15    9605
XP_005268098                                                           15    9605
XP_006720310                                                           15    9605
XP_006714202                                                           15    9605
XP_005262892                                                           15    9605
XP_005262891                                                           15    9605
>NP_000213
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DYAEAALYK 9
           D+AEAALYK
Sbjct: 696 DHAEAALYK 704
>NP_001087241
          Length = 972

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DYAEAALYK 9
           D+AEAALYK
Sbjct: 692 DHAEAALYK 700
>XP_005265799
          Length = 973

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DYAEAALYK 9
           D+AEAALYK
Sbjct: 693 DHAEAALYK 701
>XP_005265798
          Length = 976

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DYAEAALYK 9
           D+AEAALYK
Sbjct: 697 DHAEAALYK 705
>XP_005265797
          Length = 977

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DYAEAALYK 9
           D+AEAALYK
Sbjct: 697 DHAEAALYK 705
>NP_055478
          Length = 1064

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DYAEAALYK 9
            DY E ALY+
Sbjct: 1052 DYIEPALYR 1060
>XP_005271413
          Length = 973

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DYAEAALYK 9
           DY E ALY+
Sbjct: 961 DYIEPALYR 969
>XP_005271412
          Length = 1064

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DYAEAALYK 9
            DY E ALY+
Sbjct: 1052 DYIEPALYR 1060
>XP_005271411
          Length = 1064

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DYAEAALYK 9
            DY E ALY+
Sbjct: 1052 DYIEPALYR 1060
>XP_005250863
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LYK
Sbjct: 249 DYFETLLYK 257
>NP_659400
          Length = 838

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LYK
Sbjct: 249 DYFETLLYK 257
>NP_789792
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DYAEAALYK 9
           D+AE +LY+
Sbjct: 199 DWAEGSLYQ 207
>XP_006718281
          Length = 983

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DYAEAALYK 9
          D+AE +LY+
Sbjct: 89 DWAEGSLYQ 97
>NP_001138390
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 259 DYLEIAIY 266
>NP_065169
          Length = 1053

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EAALYK 9
           EAALYK
Sbjct: 376 EAALYK 381
>NP_001138386
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 262 DYLEIAIY 269
>NP_001138387
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 285 DYLEIAIY 292
>NP_000132
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 374 DYLEIAIY 381
>NP_075259
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 375 DYLEIAIY 382
>NP_001138388
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 259 DYLEIAIY 266
>NP_001138391
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 286 DYLEIAIY 293
>NP_001138385
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 375 DYLEIAIY 382
>NP_075418
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 285 DYLEIAIY 292
>NP_001273680
          Length = 358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DYAEAALYK 9
          D+AE  LYK
Sbjct: 30 DHAEYYLYK 38
>NP_055899
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DYAEAALYK 9
          D+AE  LYK
Sbjct: 86 DHAEYYLYK 94
>NP_001020279
          Length = 1251

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DYAEAAL 7
            +YAEAAL
Sbjct: 1028 NYAEAAL 1034
>NP_079212
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY   ALYK
Sbjct: 339 DYDNHALYK 347
>NP_002276
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DYAEAAL 7
            +YAEAAL
Sbjct: 1003 NYAEAAL 1009
>NP_060371
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DYAEAALY 8
          +Y EAA+Y
Sbjct: 70 NYQEAAIY 77
>NP_001273677
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DYAEAALYK 9
          D+AE  LYK
Sbjct: 86 DHAEYYLYK 94
>NP_061743
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E A Y+
Sbjct: 308 DYEETAFYE 316
>NP_114476
          Length = 817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E A Y+
Sbjct: 308 DYEETAFYE 316
>XP_006723898
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EAALYK 9
           EAALYK
Sbjct: 274 EAALYK 279
>XP_006723897
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EAALYK 9
           EAALYK
Sbjct: 274 EAALYK 279
>XP_005260524
          Length = 951

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   EAALYK 9
           EAALYK
Sbjct: 274 EAALYK 279
>XP_006719528
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DYAEAALY 8
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>XP_005253963
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1 DYAEAALY 8
         +Y EAA+Y
Sbjct: 2 NYQEAAIY 9
>XP_005253962
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DYAEAALY 8
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>XP_006717776
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 393 DYLEIAIY 400
>XP_006717775
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 279 DYLEIAIY 286
>XP_006717774
          Length = 752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 305 DYLEIAIY 312
>XP_006717773
          Length = 807

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 394 DYLEIAIY 401
>XP_006717772
          Length = 838

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 393 DYLEIAIY 400
>XP_006717771
          Length = 839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DYAEAALY 8
           DY E A+Y
Sbjct: 394 DYLEIAIY 401
>XP_005248213
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY   ALYK
Sbjct: 339 DYDNHALYK 347
>XP_005248212
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY   ALYK
Sbjct: 339 DYDNHALYK 347
>XP_005264002
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DYAEAAL 7
           +YAEAAL
Sbjct: 672 NYAEAAL 678
>XP_005264000
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DYAEAAL 7
            +YAEAAL
Sbjct: 1003 NYAEAAL 1009
>XP_006712586
          Length = 1262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DYAEAAL 7
            +YAEAAL
Sbjct: 1055 NYAEAAL 1061
>XP_005263999
          Length = 1278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DYAEAAL 7
            +YAEAAL
Sbjct: 1055 NYAEAAL 1061
>NP_001137291
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DYAEAALY 8
           +Y EAA+Y
Sbjct: 142 NYQEAAIY 149
>NP_000775
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AEAALY 8
           AEAALY
Sbjct: 169 AEAALY 174
>NP_003375
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 310 DYTEKPLYE 318
>NP_005236
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 211 DYLETKLYE 219
>NP_115901
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           +Y E  LYK
Sbjct: 127 EYEEVELYK 135
>NP_001406
          Length = 472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  YAEAALYK 9
          YA A +YK
Sbjct: 83 YANAKIYK 90
>XP_005268098
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 310 DYTEKPLYE 318
>XP_006720310
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 310 DYTEKPLYE 318
>XP_006714202
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 211 DYLETKLYE 219
>XP_005262892
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 211 DYLETKLYE 219
>XP_005262891
          Length = 4600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DYAEAALYK 9
           DY E  LY+
Sbjct: 211 DYLETKLYE 219
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.126    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 409,666
Number of extensions: 711
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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