Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     665
XP_006716142                                                           19     665
XP_005250088                                                           19     665
XP_006716141                                                           19     665
XP_005250085                                                           19     665
XP_006716140                                                           19     665
XP_005250084                                                           19     665
XP_005250083                                                           19     665
XP_005250082                                                           19     665
NP_079106                                                              17    3301
XP_005252173                                                           17    3301
XP_005248430                                                           17    3301
NP_149040                                                              17    3301
NP_005948                                                              17    4312
NP_055986                                                              17    4312
NP_001257869                                                           17    4312
XP_005255257                                                           17    4312
XP_005255256                                                           17    4312
XP_005255255                                                           17    4312
XP_005255254                                                           17    4312
XP_005255252                                                           17    4312
XP_005263520                                                           17    4312
XP_005263519                                                           17    4312
XP_005263518                                                           17    4312
XP_005263517                                                           17    4312
XP_005263515                                                           17    4312
NP_001191339                                                           16    5631
NP_002994                                                              16    5631
NP_001137473                                                           16    5631
NP_001137471                                                           16    5631
NP_001137470                                                           16    5631
NP_001191337                                                           16    5631
NP_001034662                                                           16    5631
NP_065928                                                              16    5631
XP_005256527                                                           16    5631
NP_001004755                                                           16    5631
NP_001006624                                                           16    7355
NP_060853                                                              16    7355
NP_001006623                                                           16    7355
NP_998821                                                              16    7355
XP_005263754                                                           16    7355
NP_001274273                                                           15    9605
NP_000114                                                              15    9605
NP_000052                                                              15    9605
NP_116753                                                              15    9605
NP_116754                                                              15    9605
NP_001229768                                                           15    9605
NP_001265548                                                           15    9605
NP_116755                                                              15    9605
NP_116749                                                              15    9605
NP_001161834                                                           15    9605
NP_001161832                                                           15    9605
NP_116750                                                              15    9605
NP_001161833                                                           15    9605
NP_116751                                                              15    9605
NP_001161835                                                           15    9605
NP_055337                                                              15    9605
NP_001152863                                                           15    9605
NP_001191354                                                           15    9605
NP_001229769                                                           15    9605
XP_005273163                                                           15    9605
XP_005273162                                                           15    9605
XP_005273161                                                           15    9605
XP_005273160                                                           15    9605
NP_001152862                                                           15    9605
NP_000849                                                              15    9605
>NP_733751
          Length = 4911

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4606 DGRPVFVIR 4614
>XP_006716142
          Length = 4927

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4622 DGRPVFVIR 4630
>XP_005250088
          Length = 4928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4623 DGRPVFVIR 4631
>XP_006716141
          Length = 4959

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4654 DGRPVFVIR 4662
>XP_005250085
          Length = 4979

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4678 DGRPVFVIR 4686
>XP_006716140
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4677 DGRPVFVIR 4685
>XP_005250084
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4677 DGRPVFVIR 4685
>XP_005250083
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4677 DGRPVFVIR 4685
>XP_005250082
          Length = 4983

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVRPVFVIR 9
            D RPVFVIR
Sbjct: 4678 DGRPVFVIR 4686
>NP_079106
          Length = 534

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRPVFVIR 9
           +RPVFV R
Sbjct: 170 IRPVFVSR 177
>XP_005252173
          Length = 341

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           DV P+FV+R
Sbjct: 302 DVIPLFVLR 310
>XP_005248430
          Length = 486

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VRPVFVIR 9
           +RPVFV R
Sbjct: 122 IRPVFVSR 129
>NP_149040
          Length = 475

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           DV P+FV+R
Sbjct: 302 DVIPLFVLR 310
>NP_005948
          Length = 656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 361 DVRPIF 366
>NP_055986
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 688 VRPVFLI 694
>NP_001257869
          Length = 1111

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 674 VRPVFLI 680
>XP_005255257
          Length = 774

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 337 VRPVFLI 343
>XP_005255256
          Length = 780

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 343 VRPVFLI 349
>XP_005255255
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 514 VRPVFLI 520
>XP_005255254
          Length = 1051

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 614 VRPVFLI 620
>XP_005255252
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   VRPVFVI 8
           VRPVF+I
Sbjct: 687 VRPVFLI 693
>XP_005263520
          Length = 574

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 279 DVRPIF 284
>XP_005263519
          Length = 656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 361 DVRPIF 366
>XP_005263518
          Length = 656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 361 DVRPIF 366
>XP_005263517
          Length = 656

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 361 DVRPIF 366
>XP_005263515
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DVRPVF 6
           DVRP+F
Sbjct: 402 DVRPIF 407
>NP_001191339
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_002994
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_001137473
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 303 DGRPLYVLR 311
>NP_001137471
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_001137470
          Length = 715

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_001191337
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_001034662
          Length = 719

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DVRPVFVIR 9
           D RP++V+R
Sbjct: 337 DGRPLYVLR 345
>NP_065928
          Length = 4427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DVRPVFVIR 9
          DV+P+F+ R
Sbjct: 75 DVKPLFLSR 83
>XP_005256527
          Length = 4427

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DVRPVFVIR 9
          DV+P+F+ R
Sbjct: 75 DVKPLFLSR 83
>NP_001004755
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VRPVFVIR 9
          V P+F++R
Sbjct: 10 VEPIFILR 17
>NP_001006624
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   PVFVIR 9
           PVFV+R
Sbjct: 121 PVFVVR 126
>NP_060853
          Length = 1336

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   PVFVIR 9
           PVFV+R
Sbjct: 121 PVFVVR 126
>NP_001006623
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   PVFVIR 9
           PVFV+R
Sbjct: 121 PVFVVR 126
>NP_998821
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VRPVFVIR 9
           V+P F+IR
Sbjct: 480 VQPCFIIR 487
>XP_005263754
          Length = 1133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   PVFVIR 9
           PVFV+R
Sbjct: 121 PVFVVR 126
>NP_001274273
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RPVFVI 8
           RP+F+I
Sbjct: 502 RPIFII 507
>NP_000114
          Length = 1186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2  VRPVFV 7
          +RP+FV
Sbjct: 70 IRPIFV 75
>NP_000052
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   RPVFVI 8
           RP+F+I
Sbjct: 468 RPIFII 473
>NP_116753
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 689 DNKPVFIV 696
>NP_116754
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 700 DNKPVFIV 707
>NP_001229768
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 114 DLRPIYI 120
>NP_001265548
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 689 DNKPVFIV 696
>NP_116755
          Length = 1340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 700 DNKPVFIV 707
>NP_116749
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_001161834
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_001161832
          Length = 1339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_116750
          Length = 1347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_001161833
          Length = 1065

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_116751
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_001161835
          Length = 1329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_055337
          Length = 1021

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DVRPVFVI 8
           D +PVF++
Sbjct: 668 DNKPVFIV 675
>NP_001152863
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 114 DLRPIYI 120
>NP_001191354
          Length = 1640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   VRPVFV 7
           +RP+FV
Sbjct: 524 IRPIFV 529
>NP_001229769
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 135 DLRPIYI 141
>XP_005273163
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 114 DLRPIYI 120
>XP_005273162
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 114 DLRPIYI 120
>XP_005273161
          Length = 263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 180 DLRPIYI 186
>XP_005273160
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 180 DLRPIYI 186
>NP_001152862
          Length = 218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 135 DLRPIYI 141
>NP_000849
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 1   DVRPVFV 7
           D+RP+++
Sbjct: 114 DLRPIYI 120
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.163    0.500 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 515,998
Number of extensions: 757
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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