Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     869
XP_005266703                                                           19     869
NP_001005207                                                           17    4312
NP_056109                                                              17    4312
XP_005257447                                                           17    4312
XP_005257446                                                           17    4312
XP_005257445                                                           17    4312
XP_005257444                                                           17    4312
XP_005257443                                                           17    4312
XP_005257442                                                           17    4312
XP_005273894                                                           17    4312
NP_878253                                                              17    4312
NP_001171835                                                           16    5631
NP_116264                                                              16    5631
XP_005257804                                                           16    5631
XP_005257803                                                           16    5631
NP_064446                                                              16    5631
NP_064425                                                              15    9605
NP_001001290                                                           15    9605
NP_004298                                                              15    9605
NP_775098                                                              15    9605
NP_001159522                                                           15    9605
NP_037528                                                              15    9605
NP_001269970                                                           15    9605
NP_001269971                                                           15    9605
NP_001164562                                                           15    9605
NP_079517                                                              15    9605
NP_060538                                                              15    9605
NP_001129193                                                           15    9605
NP_001265246                                                           15    9605
NP_036436                                                              15    9605
NP_848620                                                              15    9605
XP_005261006                                                           15    9605
XP_006724055                                                           15    9605
XP_005273608                                                           15    9605
XP_005273607                                                           15    9605
XP_005248330                                                           15    9605
XP_005248158                                                           15    9605
XP_006714075                                                           15    9605
XP_006714074                                                           15    9605
XP_006714073                                                           15    9605
XP_006714072                                                           15    9605
XP_006714071                                                           15    9605
XP_006714070                                                           15    9605
XP_006714069                                                           15    9605
XP_006714068                                                           15    9605
XP_006714032                                                           15    9605
XP_006714031                                                           15    9605
>NP_443179
          Length = 2170

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVGIETLAK 9
            DVGI TLAK
Sbjct: 2090 DVGIATLAK 2098
>XP_005266703
          Length = 1501

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DVGIETLAK 9
            DVGI TLAK
Sbjct: 1421 DVGIATLAK 1429
>NP_001005207
          Length = 964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>NP_056109
          Length = 964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>XP_005257447
          Length = 925

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>XP_005257446
          Length = 925

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>XP_005257445
          Length = 930

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>XP_005257444
          Length = 930

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 700 DLGMELLAK 708
>XP_005257443
          Length = 939

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 700 DLGMELLAK 708
>XP_005257442
          Length = 973

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DVGIETLAK 9
           D+G+E LAK
Sbjct: 734 DLGMELLAK 742
>XP_005273894
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VGIETLAK 9
           V IETLAK
Sbjct: 388 VSIETLAK 395
>NP_878253
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VGIETLAK 9
           V IETLAK
Sbjct: 388 VSIETLAK 395
>NP_001171835
          Length = 404

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           DVG  TLA+
Sbjct: 256 DVGFTTLAR 264
>NP_116264
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           DVG  TLA+
Sbjct: 288 DVGFTTLAR 296
>XP_005257804
          Length = 406

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           DVG  TLA+
Sbjct: 258 DVGFTTLAR 266
>XP_005257803
          Length = 438

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           DVG  TLA+
Sbjct: 290 DVGFTTLAR 298
>NP_064446
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DVGIETL 7
           DVG++TL
Sbjct: 247 DVGVDTL 253
>NP_064425
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GIETLA 8
           GIETLA
Sbjct: 362 GIETLA 367
>NP_001001290
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GIETLA 8
           GIETLA
Sbjct: 333 GIETLA 338
>NP_004298
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_775098
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_001159522
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>NP_037528
          Length = 1055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGIETL 7
           VGIETL
Sbjct: 676 VGIETL 681
>NP_001269970
          Length = 1125

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGIETL 7
           VGIETL
Sbjct: 676 VGIETL 681
>NP_001269971
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGIETL 7
           VGIETL
Sbjct: 676 VGIETL 681
>NP_001164562
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIETLAK 9
           +G++T+AK
Sbjct: 120 LGVDTIAK 127
>NP_079517
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   VGIETLAK 9
           +G++T+AK
Sbjct: 173 LGVDTIAK 180
>NP_060538
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGIETLAK 9
          +GIET++K
Sbjct: 78 LGIETVSK 85
>NP_001129193
          Length = 973

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGIETLAK 9
          +GIET++K
Sbjct: 78 LGIETVSK 85
>NP_001265246
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           D G+E LAK
Sbjct: 344 DHGVEYLAK 352
>NP_036436
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           D G+E LAK
Sbjct: 391 DHGVEYLAK 399
>NP_848620
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VGIETLAK 9
           VG+ T+AK
Sbjct: 313 VGLSTMAK 320
>XP_005261006
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGIETL 7
           VGIETL
Sbjct: 272 VGIETL 277
>XP_006724055
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   VGIETL 7
           VGIETL
Sbjct: 377 VGIETL 382
>XP_005273608
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGIETLAK 9
          +GIET++K
Sbjct: 78 LGIETVSK 85
>XP_005273607
          Length = 937

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VGIETLAK 9
          +GIET++K
Sbjct: 78 LGIETVSK 85
>XP_005248330
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DVGIETLAK 9
           D G+E LAK
Sbjct: 386 DHGVEYLAK 394
>XP_005248158
          Length = 737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714075
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714074
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714073
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714072
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714071
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714070
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714069
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714068
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DVGIETLA 8
          D G++TLA
Sbjct: 8  DSGVDTLA 15
>XP_006714032
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GIETLA 8
           GIETLA
Sbjct: 333 GIETLA 338
>XP_006714031
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   GIETLA 8
           GIETLA
Sbjct: 362 GIETLA 367
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.310    0.135    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 380,454
Number of extensions: 498
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package