Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_071934                                                              17    2528
NP_001026884                                                           17    2528
XP_005268062                                                           17    2528
XP_005268061                                                           17    2528
NP_598328                                                              17    3301
NP_008881                                                              17    3301
XP_006713376                                                           17    3301
XP_006713375                                                           17    3301
NP_001153605                                                           17    4312
NP_062816                                                              17    4312
NP_001153606                                                           17    4312
NP_001153602                                                           17    4312
NP_001153604                                                           17    4312
NP_061836                                                              16    5631
NP_219485                                                              16    5631
NP_001011699                                                           16    5631
NP_387505                                                              16    5631
XP_005260211                                                           16    5631
NP_001120929                                                           16    7355
NP_003310                                                              16    7355
NP_066940                                                              16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_001129246                                                           16    7355
NP_001264301                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
XP_006712235                                                           16    7355
XP_006712234                                                           16    7355
NP_003481                                                              16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_058649                                                              15    9605
NP_510880                                                              15    9605
NP_976063                                                              15    9605
>NP_071934
          Length = 1249

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DTSLRKSFA 9
            DTSL KSF+
Sbjct: 1186 DTSLDKSFS 1194
>NP_001026884
          Length = 1240

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DTSLRKSFA 9
            DTSL KSF+
Sbjct: 1186 DTSLDKSFS 1194
>XP_005268062
          Length = 1272

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DTSLRKSFA 9
            DTSL KSF+
Sbjct: 1218 DTSLDKSFS 1226
>XP_005268061
          Length = 1281

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DTSLRKSFA 9
            DTSL KSF+
Sbjct: 1218 DTSLDKSFS 1226
>NP_598328
          Length = 582

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           SLRKSFA
Sbjct: 571 SLRKSFA 577
>NP_008881
          Length = 705

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           SLRKSFA
Sbjct: 694 SLRKSFA 700
>XP_006713376
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           SLRKSFA
Sbjct: 314 SLRKSFA 320
>XP_006713375
          Length = 421

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           SLRKSFA
Sbjct: 410 SLRKSFA 416
>NP_001153605
          Length = 951

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DTSLRKSF 8
           D S+RKSF
Sbjct: 820 DRSMRKSF 827
>NP_062816
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DTSLRKSF 8
           D S+RKSF
Sbjct: 801 DRSMRKSF 808
>NP_001153606
          Length = 822

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DTSLRKSF 8
           D S+RKSF
Sbjct: 691 DRSMRKSF 698
>NP_001153602
          Length = 923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DTSLRKSF 8
           D S+RKSF
Sbjct: 792 DRSMRKSF 799
>NP_001153604
          Length = 942

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DTSLRKSF 8
           D S+RKSF
Sbjct: 811 DRSMRKSF 818
>NP_061836
          Length = 2320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DTSLRKS 7
           DT+LRKS
Sbjct: 949 DTTLRKS 955
>NP_219485
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           D  LR+SFA
Sbjct: 305 DLELRRSFA 313
>NP_001011699
          Length = 409

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           D  LR+SFA
Sbjct: 304 DLELRRSFA 312
>NP_387505
          Length = 2269

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DTSLRKS 7
           DT+LRKS
Sbjct: 949 DTTLRKS 955
>XP_005260211
          Length = 265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           D  LR+SFA
Sbjct: 160 DLELRRSFA 168
>NP_001120929
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  DTSLRK 6
          DTSLRK
Sbjct: 21 DTSLRK 26
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 26744 DTSLQGSFS 26752
>NP_066940
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DTSLRK 6
           DTSLRK
Sbjct: 103 DTSLRK 108
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 26869 DTSLQGSFS 26877
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 34168 DTSLQGSFS 34176
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 33241 DTSLQGSFS 33249
>NP_001129246
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           +LRKSFA
Sbjct: 568 NLRKSFA 574
>NP_001264301
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           DTS R SFA
Sbjct: 912 DTSNRGSFA 920
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 22481 DTSLQGSFS 22489
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 23840 DTSLQGSFS 23848
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 33796 DTSLQGSFS 33804
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 35302 DTSLQGSFS 35310
>XP_006712235
          Length = 1180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           DTS R SFA
Sbjct: 876 DTSNRGSFA 884
>XP_006712234
          Length = 1215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DTSLRKSFA 9
           DTS R SFA
Sbjct: 911 DTSNRGSFA 919
>NP_003481
          Length = 580

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   SLRKSFA 9
           +LRKSFA
Sbjct: 569 NLRKSFA 575
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 35809 DTSLQGSFS 35817
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1     DTSLRKSFA 9
             DTSL+ SF+
Sbjct: 26936 DTSLQGSFS 26944
>NP_058649
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   LRKSFA 9
           LRKSFA
Sbjct: 121 LRKSFA 126
>NP_510880
          Length = 2054

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TSLRKSF 8
            TS+RK+F
Sbjct: 1003 TSMRKTF 1009
>NP_976063
          Length = 2039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    TSLRKSF 8
            TS+RK+F
Sbjct: 1003 TSMRKTF 1009
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.122    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,601
Number of extensions: 783
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package