Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002515                                                              19     665
NP_056271                                                              17    4312
NP_055938                                                              17    4312
XP_005264780                                                           17    4312
XP_006713127                                                           17    4312
XP_006713126                                                           17    4312
XP_005264779                                                           17    4312
XP_005264778                                                           17    4312
XP_005264777                                                           17    4312
NP_775960                                                              16    5631
XP_005251991                                                           16    5631
NP_003144                                                              16    7355
NP_001171549                                                           16    7355
NP_001171550                                                           16    7355
NP_003027                                                              16    7355
NP_004154                                                              16    7355
NP_542166                                                              16    7355
NP_001171551                                                           16    7355
NP_001171552                                                           16    7355
NP_057069                                                              16    7355
NP_056357                                                              16    7355
XP_006723630                                                           16    7355
XP_005260777                                                           16    7355
XP_006722581                                                           16    7355
XP_005266791                                                           16    7355
XP_005266790                                                           16    7355
XP_006719638                                                           16    7355
XP_006719637                                                           16    7355
XP_006719636                                                           16    7355
XP_005244833                                                           16    7355
XP_005244832                                                           16    7355
NP_699207                                                              16    7355
NP_065853                                                              15    9605
NP_001107228                                                           15    9605
NP_001244918                                                           15    9605
NP_001107227                                                           15    9605
NP_001944                                                              15    9605
NP_001244917                                                           15    9605
NP_056390                                                              15    9605
NP_001096616                                                           15    9605
NP_001096618                                                           15    9605
NP_001096617                                                           15    9605
NP_006377                                                              15    9605
NP_001271230                                                           15    9605
NP_001091974                                                           15    9605
NP_001271231                                                           15    9605
NP_061155                                                              15    9605
NP_006378                                                              15    9605
XP_005271684                                                           15    9605
XP_006715810                                                           15    9605
XP_006715809                                                           15    9605
>NP_002515
          Length = 189

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DTKQARELA 9
           DTKQA ELA
Sbjct: 126 DTKQAHELA 134
>NP_056271
          Length = 580

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           D+K+AREL
Sbjct: 276 DSKRAREL 283
>NP_055938
          Length = 1034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 635 DTRQSREM 642
>XP_005264780
          Length = 686

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 287 DTRQSREM 294
>XP_006713127
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 346 DTRQSREM 353
>XP_006713126
          Length = 980

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 581 DTRQSREM 588
>XP_005264779
          Length = 989

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 590 DTRQSREM 597
>XP_005264778
          Length = 1001

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 602 DTRQSREM 609
>XP_005264777
          Length = 1003

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DTKQAREL 8
           DT+Q+RE+
Sbjct: 604 DTRQSREM 611
>NP_775960
          Length = 1285

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DTKQARELA 9
           DTK++ ELA
Sbjct: 479 DTKESLELA 487
>XP_005251991
          Length = 953

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DTKQARELA 9
           DTK++ ELA
Sbjct: 147 DTKESLELA 155
>NP_003144
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>NP_001171549
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>NP_001171550
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>NP_003027
          Length = 728

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK+A+E
Sbjct: 554 DTKEAKE 560
>NP_004154
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 146 RQARELA 152
>NP_542166
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK+A+E
Sbjct: 499 DTKEAKE 505
>NP_001171551
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 209 KQARELS 215
>NP_001171552
          Length = 737

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 209 KQARELS 215
>NP_057069
          Length = 503

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DTKQARELA 9
           +TKQ  ELA
Sbjct: 206 ETKQQEELA 214
>NP_056357
          Length = 1272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK+A+E
Sbjct: 499 DTKEAKE 505
>XP_006723630
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DTKQARELA 9
          +TKQ  ELA
Sbjct: 44 ETKQQEELA 52
>XP_005260777
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DTKQARELA 9
           +TKQ  ELA
Sbjct: 206 ETKQQEELA 214
>XP_006722581
          Length = 182

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 146 RQARELA 152
>XP_005266791
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 146 RQARELA 152
>XP_005266790
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 146 RQARELA 152
>XP_006719638
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>XP_006719637
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>XP_006719636
          Length = 847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           KQAREL+
Sbjct: 319 KQARELS 325
>XP_005244833
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK+A+E
Sbjct: 266 DTKEAKE 272
>XP_005244832
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK+A+E
Sbjct: 556 DTKEAKE 562
>NP_699207
          Length = 555

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TKQARE 7
           TKQARE
Sbjct: 481 TKQARE 486
>NP_065853
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK++RE
Sbjct: 685 DTKKSRE 691
>NP_001107228
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 246 EQARELA 252
>NP_001244918
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 246 EQARELA 252
>NP_001107227
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 246 EQARELA 252
>NP_001944
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 246 EQARELA 252
>NP_001244917
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   KQARELA 9
           +QARELA
Sbjct: 246 EQARELA 252
>NP_056390
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DTKQARELA 9
            DT +A+E A
Sbjct: 1180 DTSEAKEFA 1188
>NP_001096616
          Length = 1299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DTKQARELA 9
            DT +A+E A
Sbjct: 1180 DTSEAKEFA 1188
>NP_001096618
          Length = 1293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DTKQARELA 9
            DT +A+E A
Sbjct: 1174 DTSEAKEFA 1182
>NP_001096617
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DTKQARELA 9
            DT +A+E A
Sbjct: 1201 DTSEAKEFA 1209
>NP_006377
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQAREL 8
           KQAREL
Sbjct: 528 KQAREL 533
>NP_001271230
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DTKQAREL 8
            DTK+ R+L
Sbjct: 1053 DTKEERDL 1060
>NP_001091974
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQAREL 8
           KQAREL
Sbjct: 528 KQAREL 533
>NP_001271231
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DTKQAREL 8
            DTK+ R+L
Sbjct: 1052 DTKEERDL 1059
>NP_061155
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DTKQAREL 8
            DTK+ R+L
Sbjct: 1090 DTKEERDL 1097
>NP_006378
          Length = 916

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   KQAREL 8
           KQAREL
Sbjct: 228 KQAREL 233
>XP_005271684
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DTKQARE 7
           DTK++RE
Sbjct: 685 DTKKSRE 691
>XP_006715810
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DTKQAREL 8
            DTK+ R+L
Sbjct: 1071 DTKEERDL 1078
>XP_006715809
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DTKQAREL 8
            DTK+ R+L
Sbjct: 1108 DTKEERDL 1115
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.115    0.276 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 410,805
Number of extensions: 842
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package