Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              18    1482
XP_006716142                                                           18    1482
XP_005250088                                                           18    1482
XP_006716141                                                           18    1482
XP_005250085                                                           18    1482
XP_006716140                                                           18    1482
XP_005250084                                                           18    1482
XP_005250083                                                           18    1482
XP_005250082                                                           18    1482
NP_006177                                                              18    1935
XP_005246680                                                           18    1935
XP_005246679                                                           18    1935
XP_006712616                                                           18    1935
XP_005246678                                                           18    1935
NP_036223                                                              16    5631
NP_002079                                                              16    5631
XP_006723233                                                           16    5631
XP_006723232                                                           16    5631
XP_005258879                                                           16    5631
XP_005258878                                                           16    5631
NP_115627                                                              16    7355
NP_612410                                                              16    7355
XP_006718583                                                           16    7355
XP_006718582                                                           16    7355
NP_003473                                                              15    9605
NP_057095                                                              15    9605
NP_001019903                                                           15    9605
NP_004609                                                              15    9605
XP_005256834                                                           15    9605
XP_005256833                                                           15    9605
XP_006719679                                                           15    9605
XP_005269219                                                           15    9605
XP_006719678                                                           15    9605
XP_006719677                                                           15    9605
XP_005245943                                                           15    9605
XP_006710737                                                           15    9605
XP_005245946                                                           15    9605
XP_005245945                                                           15    9605
XP_005245944                                                           15    9605
XP_005245942                                                           15    9605
>NP_733751
          Length = 4911

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2580 SVVEASSN 2587
>XP_006716142
          Length = 4927

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_005250088
          Length = 4928

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_006716141
          Length = 4959

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_005250085
          Length = 4979

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_006716140
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_005250084
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>XP_005250083
          Length = 4982

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2596 SVVEASSN 2603
>XP_005250082
          Length = 4983

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    SVVEASSN 9
            SVVEASSN
Sbjct: 2597 SVVEASSN 2604
>NP_006177
          Length = 598

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DS+VE SSN
Sbjct: 484 DSIVEFSSN 492
>XP_005246680
          Length = 535

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DS+VE SSN
Sbjct: 421 DSIVEFSSN 429
>XP_005246679
          Length = 535

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DS+VE SSN
Sbjct: 421 DSIVEFSSN 429
>XP_006712616
          Length = 584

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DS+VE SSN
Sbjct: 470 DSIVEFSSN 478
>XP_005246678
          Length = 609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DS+VE SSN
Sbjct: 495 DSIVEFSSN 503
>NP_036223
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           +S VEASSN
Sbjct: 168 NSSVEASSN 176
>NP_002079
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSVVEASSN 9
           D +VE SSN
Sbjct: 255 DGIVEDSSN 263
>XP_006723233
          Length = 912

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSVVEASSN 9
           D +VE SSN
Sbjct: 187 DGIVEDSSN 195
>XP_006723232
          Length = 981

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSVVEASSN 9
           D +VE SSN
Sbjct: 255 DGIVEDSSN 263
>XP_005258879
          Length = 942

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSVVEASSN 9
           D +VE SSN
Sbjct: 255 DGIVEDSSN 263
>XP_005258878
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSVVEASSN 9
           D +VE SSN
Sbjct: 255 DGIVEDSSN 263
>NP_115627
          Length = 1476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSVVEASS 8
           DSV+EAS+
Sbjct: 538 DSVLEASA 545
>NP_612410
          Length = 273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSVVEASS 8
           DS+ EASS
Sbjct: 201 DSIYEASS 208
>XP_006718583
          Length = 1482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSVVEASS 8
           DSV+EAS+
Sbjct: 460 DSVLEASA 467
>XP_006718582
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSVVEASS 8
           DSV+EAS+
Sbjct: 538 DSVLEASA 545
>NP_003473
          Length = 5537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSVVEASS 8
            DS+V ASS
Sbjct: 4703 DSIVPASS 4710
>NP_057095
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 185 DSVIQNASN 193
>NP_001019903
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>NP_004609
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSVVEAS 7
           DSV+EAS
Sbjct: 693 DSVLEAS 699
>XP_005256834
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSVVEAS 7
           DSV+EAS
Sbjct: 223 DSVLEAS 229
>XP_005256833
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSVVEAS 7
           DSV+EAS
Sbjct: 598 DSVLEAS 604
>XP_006719679
          Length = 5536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSVVEASS 8
            DS+V ASS
Sbjct: 4702 DSIVPASS 4709
>XP_005269219
          Length = 5537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSVVEASS 8
            DS+V ASS
Sbjct: 4703 DSIVPASS 4710
>XP_006719678
          Length = 5539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSVVEASS 8
            DS+V ASS
Sbjct: 4705 DSIVPASS 4712
>XP_006719677
          Length = 5540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSVVEASS 8
            DS+V ASS
Sbjct: 4706 DSIVPASS 4713
>XP_005245943
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>XP_006710737
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>XP_005245946
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>XP_005245945
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>XP_005245944
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 109 DSVIQNASN 117
>XP_005245942
          Length = 401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSVVEASSN 9
           DSV++ +SN
Sbjct: 213 DSVIQNASN 221
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.279   0.0975    0.212 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 257,556
Number of extensions: 330
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.6 bits)
S2: 28 (15.4 bits)

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