Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              19     665
NP_001075109                                                           19     665
NP_006428                                                              17    3301
NP_001161710                                                           17    3301
NP_001161709                                                           17    3301
NP_001161708                                                           17    3301
NP_009298                                                              17    3301
NP_055524                                                              17    3301
NP_005149                                                              17    3301
NP_065961                                                              17    3301
NP_001161711                                                           17    3301
NP_001158137                                                           17    3301
XP_006716135                                                           17    3301
XP_006716134                                                           17    3301
XP_005245145                                                           17    3301
NP_001129472                                                           17    3301
NP_056996                                                              17    4312
XP_005250985                                                           17    4312
XP_006716634                                                           17    4312
NP_689540                                                              16    5631
XP_006720086                                                           16    5631
XP_006720085                                                           16    5631
XP_006720084                                                           16    5631
NP_786924                                                              16    5631
NP_001258973                                                           16    7355
NP_001258989                                                           16    7355
NP_003152                                                              16    7355
NP_001258972                                                           16    7355
NP_001258971                                                           16    7355
XP_006722072                                                           16    7355
XP_006712395                                                           16    7355
NP_004314                                                              15    9605
NP_001165886                                                           15    9605
NP_004658                                                              15    9605
NP_001078956                                                           15    9605
NP_001165883                                                           15    9605
NP_001103373                                                           15    9605
NP_620409                                                              15    9605
NP_001073927                                                           15    9605
NP_116203                                                              15    9605
XP_006723106                                                           15    9605
XP_006723105                                                           15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_005254026                                                           15    9605
XP_005254025                                                           15    9605
XP_005250571                                                           15    9605
XP_005250570                                                           15    9605
XP_006710998                                                           15    9605
XP_006710377                                                           15    9605
NP_604393                                                              15    9605
NP_065930                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSTLSEEVS 9
            DSTLSEE+S
Sbjct: 2033 DSTLSEEMS 2041
>NP_001075109
          Length = 4097

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSTLSEEVS 9
            DSTLSEE+S
Sbjct: 2033 DSTLSEEMS 2041
>NP_006428
          Length = 1724

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   STLSEEVS 9
           STLS+EVS
Sbjct: 257 STLSQEVS 264
>NP_001161710
          Length = 1058

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 524 DSSISEEVA 532
>NP_001161709
          Length = 1079

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 545 DSSISEEVA 553
>NP_001161708
          Length = 1161

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 524 DSSISEEVA 532
>NP_009298
          Length = 1182

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 545 DSSISEEVA 553
>NP_055524
          Length = 3546

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSTLSEEVS 9
            DSTL+EE S
Sbjct: 3458 DSTLAEEES 3466
>NP_005149
          Length = 1167

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 530 DSSISEEVA 538
>NP_065961
          Length = 1934

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSTLSEEVS 9
            DST+SEE S
Sbjct: 1417 DSTVSEESS 1425
>NP_001161711
          Length = 1043

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 509 DSSISEEVA 517
>NP_001158137
          Length = 1950

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSTLSEEVS 9
            DST+SEE S
Sbjct: 1417 DSTVSEESS 1425
>XP_006716135
          Length = 718

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           DST+SEE S
Sbjct: 201 DSTVSEESS 209
>XP_006716134
          Length = 1847

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSTLSEEVS 9
            DST+SEE S
Sbjct: 1314 DSTVSEESS 1322
>XP_005245145
          Length = 1146

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 509 DSSISEEVA 517
>NP_001129472
          Length = 1064

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DSTLSEEVS 9
           DS++SEEV+
Sbjct: 530 DSSISEEVA 538
>NP_056996
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    STLSEEVS 9
            STL EEVS
Sbjct: 1082 STLDEEVS 1089
>XP_005250985
          Length = 1406

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    STLSEEVS 9
            STL EEVS
Sbjct: 1082 STLDEEVS 1089
>XP_006716634
          Length = 1420

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    STLSEEVS 9
            STL EEVS
Sbjct: 1096 STLDEEVS 1103
>NP_689540
          Length = 723

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STLSEEVS 9
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720086
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STLSEEVS 9
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720085
          Length = 704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STLSEEVS 9
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>XP_006720084
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STLSEEVS 9
           S LSEEVS
Sbjct: 134 SALSEEVS 141
>NP_786924
          Length = 425

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSTLSEEV 8
           DSTL E+V
Sbjct: 233 DSTLKEDV 240
>NP_001258973
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 344 DSTLSESAN 352
>NP_001258989
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 374 DSTLSESAN 382
>NP_003152
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 397 DSTLSESAN 405
>NP_001258972
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 397 DSTLSESAN 405
>NP_001258971
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 374 DSTLSESAN 382
>XP_006722072
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSTLSEEVS 9
           DSTLSE  +
Sbjct: 194 DSTLSESAN 202
>XP_006712395
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           DS+LSE+ S
Sbjct: 498 DSSLSEDCS 506
>NP_004314
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           +ST SEEV+
Sbjct: 127 ESTRSEEVT 135
>NP_001165886
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DSTLSEEVS 9
          +ST SEEV+
Sbjct: 12 ESTRSEEVT 20
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    STLSEEV 8
            STL+EEV
Sbjct: 2140 STLAEEV 2146
>NP_001078956
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSTLSEE 7
          D+T+SEE
Sbjct: 54 DNTISEE 60
>NP_001165883
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSTLSEEV 8
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>NP_001103373
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           +STL E+VS
Sbjct: 199 NSTLREQVS 207
>NP_620409
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSTLSEEV 8
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>NP_001073927
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DSTLSEEVS 9
          +ST+S E+S
Sbjct: 85 ESTVSSEIS 93
>NP_116203
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           +STL E+VS
Sbjct: 199 NSTLREQVS 207
>XP_006723106
          Length = 971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 681 DSTLSE 686
>XP_006723105
          Length = 1028

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 681 DSTLSE 686
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    STLSEEV 8
            STL+EEV
Sbjct: 2054 STLAEEV 2060
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    STLSEEV 8
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    STLSEEV 8
            STL+EEV
Sbjct: 2102 STLAEEV 2108
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    STLSEEV 8
            STL+EEV
Sbjct: 2135 STLAEEV 2141
>XP_005254026
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           +STL E+VS
Sbjct: 199 NSTLREQVS 207
>XP_005254025
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DSTLSEEVS 9
           +STL E+VS
Sbjct: 199 NSTLREQVS 207
>XP_005250571
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 267 DSTLSE 272
>XP_005250570
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 348 DSTLSE 353
>XP_006710998
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSTLSEEV 8
          DST +EEV
Sbjct: 60 DSTRTEEV 67
>XP_006710377
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSTLSEE 7
          D+T+SEE
Sbjct: 54 DNTISEE 60
>NP_604393
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 647 DSTLSE 652
>NP_065930
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DSTLSE 6
           DSTLSE
Sbjct: 399 DSTLSE 404
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.276   0.0996    0.212 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,127
Number of extensions: 1022
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.5 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package