Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1482
NP_001035957                                                           18    1482
XP_006721991                                                           18    1482
XP_006721990                                                           18    1482
XP_006721989                                                           18    1482
XP_005258041                                                           18    1482
XP_006721988                                                           18    1482
XP_006721987                                                           18    1482
XP_006721986                                                           18    1482
XP_005258040                                                           18    1482
XP_006721985                                                           18    1482
NP_005957                                                              17    2528
XP_005246643                                                           17    2528
XP_005246642                                                           17    2528
XP_005246641                                                           17    2528
XP_005246640                                                           17    2528
XP_005246638                                                           17    2528
XP_005246639                                                           17    2528
XP_005246636                                                           17    2528
XP_005246637                                                           17    2528
XP_006712603                                                           17    2528
NP_001093900                                                           16    5631
NP_076988                                                              16    5631
XP_006714348                                                           16    5631
XP_006714347                                                           16    5631
NP_001093896                                                           16    5631
NP_001093898                                                           16    5631
NP_066982                                                              16    5631
NP_001093897                                                           16    5631
NP_001093899                                                           16    5631
NP_149118                                                              16    7355
NP_056110                                                              15    9605
NP_055904                                                              15    9605
XP_005258159                                                           15    9605
XP_006722384                                                           15    9605
XP_006715095                                                           15    9605
XP_006715094                                                           15    9605
XP_006715093                                                           15    9605
XP_006715092                                                           15    9605
>NP_000258
          Length = 2818

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1269 DSMQTLF 1275
>NP_001035957
          Length = 2839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1269 DSMQTLF 1275
>XP_006721991
          Length = 1632

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>XP_006721990
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>XP_006721989
          Length = 2823

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>XP_005258041
          Length = 2836

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1269 DSMQTLF 1275
>XP_006721988
          Length = 2846

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>XP_006721987
          Length = 2849

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>XP_006721986
          Length = 2854

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1266 DSMQTLF 1272
>XP_005258040
          Length = 2857

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1269 DSMQTLF 1275
>XP_006721985
          Length = 2867

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1    DSMQTLF 7
            DSMQTLF
Sbjct: 1279 DSMQTLF 1285
>NP_005957
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246643
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246642
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246641
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246640
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246638
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246639
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246636
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_005246637
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>XP_006712603
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DSMQTLFE 8
           DS+QTLF+
Sbjct: 343 DSVQTLFQ 350
>NP_001093900
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 213 ESMQKLFE 220
>NP_076988
          Length = 553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMQTLFEA 9
           D  QTLF+A
Sbjct: 444 DHTQTLFQA 452
>XP_006714348
          Length = 478

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 175 ESMQKLFE 182
>XP_006714347
          Length = 527

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 224 ESMQKLFE 231
>NP_001093896
          Length = 608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 305 ESMQKLFE 312
>NP_001093898
          Length = 559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 256 ESMQKLFE 263
>NP_066982
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 305 ESMQKLFE 312
>NP_001093897
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 304 ESMQKLFE 311
>NP_001093899
          Length = 558

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           +SMQ LFE
Sbjct: 255 ESMQKLFE 262
>NP_149118
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DSMQTLFE 8
           D +QTLF+
Sbjct: 497 DPLQTLFQ 504
>NP_056110
          Length = 2005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DSMQTLF 7
           D MQTL+
Sbjct: 397 DDMQTLY 403
>NP_055904
          Length = 2517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMQTLFEA 9
           DS+ +LF+A
Sbjct: 817 DSIHSLFDA 825
>XP_005258159
          Length = 1817

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DSMQTLF 7
           D MQTL+
Sbjct: 209 DDMQTLY 215
>XP_006722384
          Length = 1877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DSMQTLF 7
           D MQTL+
Sbjct: 269 DDMQTLY 275
>XP_006715095
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMQTLFEA 9
           DS+ +LF+A
Sbjct: 346 DSIHSLFDA 354
>XP_006715094
          Length = 2407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMQTLFEA 9
           DS+ +LF+A
Sbjct: 707 DSIHSLFDA 715
>XP_006715093
          Length = 2459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMQTLFEA 9
           DS+ +LF+A
Sbjct: 759 DSIHSLFDA 767
>XP_006715092
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMQTLFEA 9
           DS+ +LF+A
Sbjct: 817 DSIHSLFDA 825
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.122    0.308 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 335,890
Number of extensions: 495
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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