Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004251                                                              19     665
NP_000042                                                              16    5631
NP_006166                                                              16    5631
NP_001248392                                                           16    5631
NP_932326                                                              16    5631
NP_001194005                                                           16    5631
NP_543024                                                              16    5631
XP_006723777                                                           16    5631
XP_005260352                                                           16    5631
XP_005271621                                                           16    5631
XP_006718907                                                           16    5631
XP_006718906                                                           16    5631
XP_005271619                                                           16    5631
XP_005271618                                                           16    5631
XP_005269924                                                           16    5631
XP_006717933                                                           16    5631
XP_005269921                                                           16    5631
NP_150094                                                              16    7355
NP_443132                                                              16    7355
NP_937757                                                              16    7355
NP_937756                                                              16    7355
NP_060676                                                              15    9605
NP_525022                                                              15    9605
NP_671729                                                              15    9605
NP_932341                                                              15    9605
XP_005252834                                                           15    9605
XP_006725198                                                           15    9605
XP_006725197                                                           15    9605
XP_006725196                                                           15    9605
XP_006725195                                                           15    9605
XP_006725194                                                           15    9605
XP_005256994                                                           15    9605
XP_005256993                                                           15    9605
XP_005256992                                                           15    9605
XP_006721697                                                           15    9605
XP_006721696                                                           15    9605
XP_005256991                                                           15    9605
XP_005256102                                                           15    9605
XP_006718198                                                           15    9605
XP_005252833                                                           15    9605
XP_006718197                                                           15    9605
XP_006718196                                                           15    9605
XP_006718195                                                           15    9605
XP_005252832                                                           15    9605
XP_006713161                                                           15    9605
XP_006713160                                                           15    9605
>NP_004251
          Length = 1208

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DSMDFLAVK 9
           DS DFLAVK
Sbjct: 835 DSTDFLAVK 843
>NP_000042
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 658 DKMDFLTI 665
>NP_006166
          Length = 1695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 768 DSLTFLAAK 776
>NP_001248392
          Length = 1731

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 803 DSLTFLAAK 811
>NP_932326
          Length = 1730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 803 DSLTFLAAK 811
>NP_001194005
          Length = 423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSMDFLA 7
          D+MDF+A
Sbjct: 73 DTMDFIA 79
>NP_543024
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSMDFLA 7
          D+MDF+A
Sbjct: 73 DTMDFIA 79
>XP_006723777
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSMDFLA 7
          D+MDF+A
Sbjct: 73 DTMDFIA 79
>XP_005260352
          Length = 576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DSMDFLA 7
          D+MDF+A
Sbjct: 73 DTMDFIA 79
>XP_005271621
          Length = 2708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 310 DKMDFLTI 317
>XP_006718907
          Length = 3050

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 658 DKMDFLTI 665
>XP_006718906
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 658 DKMDFLTI 665
>XP_005271619
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 658 DKMDFLTI 665
>XP_005271618
          Length = 3056

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DSMDFLAV 8
           D MDFL +
Sbjct: 658 DKMDFLTI 665
>XP_005269924
          Length = 1627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 803 DSLTFLAAK 811
>XP_006717933
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 803 DSLTFLAAK 811
>XP_005269921
          Length = 1696

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSMDFLAVK 9
           DS+ FLA K
Sbjct: 768 DSLTFLAAK 776
>NP_150094
          Length = 3564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DFLAVK 9
           DFLAVK
Sbjct: 636 DFLAVK 641
>NP_443132
          Length = 3538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DFLAVK 9
           DFLAVK
Sbjct: 669 DFLAVK 674
>NP_937757
          Length = 3667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DFLAVK 9
           DFLAVK
Sbjct: 733 DFLAVK 738
>NP_937756
          Length = 3707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   DFLAVK 9
           DFLAVK
Sbjct: 773 DFLAVK 778
>NP_060676
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DSMDFL 6
           DSMDF+
Sbjct: 178 DSMDFV 183
>NP_525022
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1189 DSMDYL 1194
>NP_671729
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSMDFLAVK 9
           DS+D +A+K
Sbjct: 132 DSVDTVAIK 140
>NP_932341
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_005252834
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006725198
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006725197
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006725196
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006725195
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006725194
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_005256994
          Length = 1443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1197 DSMDYL 1202
>XP_005256993
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1108 DSMDYL 1113
>XP_005256992
          Length = 1543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1108 DSMDYL 1113
>XP_006721697
          Length = 1625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1197 DSMDYL 1202
>XP_006721696
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1197 DSMDYL 1202
>XP_005256991
          Length = 1632

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DSMDFL 6
            DSMD+L
Sbjct: 1197 DSMDYL 1202
>XP_005256102
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DSMDFL 6
           DSMDF+
Sbjct: 111 DSMDFV 116
>XP_006718198
          Length = 406

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_005252833
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006718197
          Length = 537

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006718196
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006718195
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_005252832
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   SMDFLAVK 9
           S D+LAVK
Sbjct: 246 SQDWLAVK 253
>XP_006713161
          Length = 103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DSMDFLAVK 9
          DS+D +A+K
Sbjct: 79 DSVDTVAIK 87
>XP_006713160
          Length = 103

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DSMDFLAVK 9
          DS+D +A+K
Sbjct: 79 DSVDTVAIK 87
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.136    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 397,824
Number of extensions: 498
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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