Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              19     869
XP_005265800                                                           19     869
XP_006714103                                                           19     869
XP_006714102                                                           19     869
NP_002600                                                              18    1135
XP_005268521                                                           18    1135
XP_006709998                                                           17    3301
NP_001222                                                              17    4312
NP_694551                                                              16    5631
NP_478136                                                              16    7355
NP_005046                                                              16    7355
NP_690051                                                              16    7355
NP_116034                                                              16    7355
NP_001229392                                                           16    7355
NP_006038                                                              16    7355
NP_001012267                                                           16    7355
NP_001185769                                                           16    7355
NP_001185767                                                           16    7355
NP_057351                                                              16    7355
NP_001273898                                                           16    7355
NP_001273900                                                           16    7355
XP_005253100                                                           16    7355
XP_005253099                                                           16    7355
NP_001001920                                                           16    7355
NP_001439                                                              15    9605
NP_001276049                                                           15    9605
NP_001276048                                                           15    9605
NP_001276050                                                           15    9605
NP_115602                                                              15    9605
NP_003671                                                              15    9605
NP_003238                                                              15    9605
NP_775483                                                              15    9605
NP_055897                                                              15    9605
NP_071322                                                              15    9605
XP_005270110                                                           15    9605
XP_006717878                                                           15    9605
XP_005269804                                                           15    9605
XP_005269803                                                           15    9605
XP_005269802                                                           15    9605
XP_005269801                                                           15    9605
XP_005251669                                                           15    9605
XP_005251668                                                           15    9605
XP_005251666                                                           15    9605
XP_005251665                                                           15    9605
>NP_006197
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS YVSKGS
Sbjct: 846 DSNYVSKGS 854
>XP_005265800
          Length = 1089

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS YVSKGS
Sbjct: 846 DSNYVSKGS 854
>XP_006714103
          Length = 1111

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS YVSKGS
Sbjct: 868 DSNYVSKGS 876
>XP_006714102
          Length = 1114

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS YVSKGS
Sbjct: 871 DSNYVSKGS 879
>NP_002600
          Length = 1106

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS Y+SKGS
Sbjct: 854 DSNYISKGS 862
>XP_005268521
          Length = 1042

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS Y+SKGS
Sbjct: 790 DSNYISKGS 798
>XP_006709998
          Length = 187

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DSIYVSKGS 9
          +S YVSKGS
Sbjct: 38 ESGYVSKGS 46
>NP_001222
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DS+YV KG
Sbjct: 127 DSMYVFKG 134
>NP_694551
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SIYVSKG 8
           SIYVS+G
Sbjct: 417 SIYVSEG 423
>NP_478136
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  IYVSKGS 9
          IYV KGS
Sbjct: 84 IYVHKGS 90
>NP_005046
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           +SIY SKG
Sbjct: 333 ESIYRSKG 340
>NP_690051
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_116034
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           +SIY SKG
Sbjct: 274 ESIYRSKG 281
>NP_001229392
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  IYVSKGS 9
          IYV KGS
Sbjct: 84 IYVHKGS 90
>NP_006038
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_001012267
          Length = 288

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   DSIYVSKG 8
           D++Y+S+G
Sbjct: 193 DAVYLSEG 200
>NP_001185769
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_001185767
          Length = 932

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSIY++ G
Sbjct: 458 DSIYIAYG 465
>NP_057351
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYVSKGS 9
           +YVS+GS
Sbjct: 215 LYVSRGS 221
>NP_001273898
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  DSIYVSKG 8
          D++Y+S+G
Sbjct: 81 DAVYLSEG 88
>NP_001273900
          Length = 115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  DSIYVSKG 8
          D++Y+S+G
Sbjct: 20 DAVYLSEG 27
>XP_005253100
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           +SIY SKG
Sbjct: 292 ESIYRSKG 299
>XP_005253099
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           +SIY SKG
Sbjct: 315 ESIYRSKG 322
>NP_001001920
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DSIYVSK 7
           DS+YV+K
Sbjct: 137 DSLYVTK 143
>NP_001439
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  IYVSKG 8
          +YVSKG
Sbjct: 36 LYVSKG 41
>NP_001276049
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>NP_001276048
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>NP_001276050
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>NP_115602
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>NP_003671
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DSIYVSK 7
           DS+YV K
Sbjct: 385 DSLYVEK 391
>NP_003238
          Length = 1172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYVSKGS 9
           +YV+KGS
Sbjct: 190 MYVAKGS 196
>NP_775483
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>NP_055897
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DSIYVSK 7
           DS+Y++K
Sbjct: 304 DSLYITK 310
>NP_071322
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS+Y+S+ +
Sbjct: 129 DSLYISQAN 137
>XP_005270110
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DSIYVSKGS 9
           DS+Y+S+ +
Sbjct: 310 DSLYISQAN 318
>XP_006717878
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269804
          Length = 419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSIYVSKG 8
          DSI VS+G
Sbjct: 54 DSIIVSEG 61
>XP_005269803
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269802
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005269801
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSIYVSKG 8
           DSI VS+G
Sbjct: 217 DSIIVSEG 224
>XP_005251669
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>XP_005251668
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>XP_005251666
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
>XP_005251665
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DSIYVSKG 8
           DSIY  KG
Sbjct: 98  DSIYRCKG 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.123    0.314 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 532,581
Number of extensions: 1011
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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