Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     299
NP_036462                                                              20     299
NP_001243397                                                           20     299
XP_005269721                                                           20     299
NP_001092882                                                           18    1482
NP_006757                                                              18    1482
NP_001092883                                                           18    1482
XP_005273706                                                           18    1482
NP_001122405                                                           16    5631
NP_001122406                                                           16    5631
NP_775873                                                              16    5631
NP_001273683                                                           16    5631
NP_597734                                                              16    5631
NP_001092313                                                           16    5631
XP_006719585                                                           16    5631
XP_006719584                                                           16    5631
XP_005269101                                                           16    5631
XP_006719583                                                           16    5631
NP_001175                                                              16    7355
NP_001269285                                                           16    7355
NP_599028                                                              16    7355
NP_439897                                                              16    7355
NP_001269286                                                           16    7355
NP_068813                                                              15    9605
NP_001275993                                                           15    9605
NP_000225                                                              15    9605
NP_001275992                                                           15    9605
NP_612441                                                              15    9605
NP_057311                                                              15    9605
NP_055641                                                              15    9605
NP_055098                                                              15    9605
NP_001269862                                                           15    9605
NP_116208                                                              15    9605
NP_001269679                                                           15    9605
NP_003598                                                              15    9605
XP_006723280                                                           15    9605
XP_006723279                                                           15    9605
XP_005258991                                                           15    9605
XP_006723278                                                           15    9605
XP_005253888                                                           15    9605
XP_005253887                                                           15    9605
XP_006711900                                                           15    9605
XP_005273381                                                           15    9605
XP_005273380                                                           15    9605
XP_005273379                                                           15    9605
XP_006711899                                                           15    9605
XP_005273378                                                           15    9605
XP_005273377                                                           15    9605
XP_006711898                                                           15    9605
XP_006711897                                                           15    9605
XP_005273375                                                           15    9605
XP_005273374                                                           15    9605
XP_005245308                                                           15    9605
XP_006711439                                                           15    9605
XP_006711438                                                           15    9605
XP_006711437                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSETVQAIQ 9
            DSETVQA+Q
Sbjct: 1246 DSETVQAVQ 1254
>NP_036462
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSETVQAIQ 9
            DSETVQA+Q
Sbjct: 1538 DSETVQAVQ 1546
>NP_001243397
          Length = 1890

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSETVQAIQ 9
            DSETVQA+Q
Sbjct: 1355 DSETVQAVQ 1363
>XP_005269721
          Length = 2073

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DSETVQAIQ 9
            DSETVQA+Q
Sbjct: 1538 DSETVQAVQ 1546
>NP_001092882
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSETVQAIQ 9
            D ETVQA+Q
Sbjct: 1421 DLETVQAVQ 1429
>NP_006757
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSETVQAIQ 9
            D ETVQA+Q
Sbjct: 1421 DLETVQAVQ 1429
>NP_001092883
          Length = 2004

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSETVQAIQ 9
            D ETVQA+Q
Sbjct: 1421 DLETVQAVQ 1429
>XP_005273706
          Length = 1997

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    DSETVQAIQ 9
            D ETVQA+Q
Sbjct: 1414 DLETVQAVQ 1422
>NP_001122405
          Length = 1093

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSETVQA 7
           DS+TVQA
Sbjct: 889 DSDTVQA 895
>NP_001122406
          Length = 1109

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSETVQA 7
           DS+TVQA
Sbjct: 889 DSDTVQA 895
>NP_775873
          Length = 1576

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DSETVQA 7
            DSET+QA
Sbjct: 1409 DSETLQA 1415
>NP_001273683
          Length = 1230

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSETVQA 7
           DS+TVQA
Sbjct: 858 DSDTVQA 864
>NP_597734
          Length = 1261

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DSETVQA 7
           DS+TVQA
Sbjct: 889 DSDTVQA 895
>NP_001092313
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 319 DSEEIQAI 326
>XP_006719585
          Length = 1459

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DSETVQA 7
            DSET+QA
Sbjct: 1292 DSETLQA 1298
>XP_006719584
          Length = 1515

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DSETVQA 7
            DSET+QA
Sbjct: 1348 DSETLQA 1354
>XP_005269101
          Length = 1577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DSETVQA 7
            DSET+QA
Sbjct: 1410 DSETLQA 1416
>XP_006719583
          Length = 1586

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1    DSETVQA 7
            DSET+QA
Sbjct: 1419 DSETLQA 1425
>NP_001175
          Length = 2644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DSETVQAI 8
            DSETV+ I
Sbjct: 1324 DSETVEPI 1331
>NP_001269285
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSETVQAIQ 9
           DSET+Q ++
Sbjct: 495 DSETLQQVK 503
>NP_599028
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSETVQAIQ 9
           DSET+Q ++
Sbjct: 495 DSETLQQVK 503
>NP_439897
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSETVQAIQ 9
           DSET+Q ++
Sbjct: 495 DSETLQQVK 503
>NP_001269286
          Length = 355

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DSETVQAIQ 9
           DSET+Q ++
Sbjct: 194 DSETLQQVK 202
>NP_068813
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DSETVQAIQ 9
           DS+TVQ  Q
Sbjct: 202 DSKTVQRTQ 210
>NP_001275993
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 718 DSEELQAI 725
>NP_000225
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 786 DSEELQAI 793
>NP_001275992
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 755 DSEELQAI 762
>NP_612441
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DSETVQAIQ 9
           D+E V A+Q
Sbjct: 254 DTEAVSAVQ 262
>NP_057311
          Length = 1405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSETV+ I
Sbjct: 284 DSETVENI 291
>NP_055641
          Length = 1638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>NP_055098
          Length = 1254

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSETV+ I
Sbjct: 126 DSETVENI 133
>NP_001269862
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DSETVQAIQ 9
          D++TV A+Q
Sbjct: 13 DNQTVLAVQ 21
>NP_116208
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DSETVQAIQ 9
          D++TV A+Q
Sbjct: 13 DNQTVLAVQ 21
>NP_001269679
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSETVQAI 8
          DSETV+ I
Sbjct: 89 DSETVENI 96
>NP_003598
          Length = 1719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_006723280
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 380 DSEELQAI 387
>XP_006723279
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 786 DSEELQAI 793
>XP_005258991
          Length = 889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 756 DSEELQAI 763
>XP_006723278
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSE +QAI
Sbjct: 785 DSEELQAI 792
>XP_005253888
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DSETVQAIQ 9
           D+E V A+Q
Sbjct: 254 DTEAVSAVQ 262
>XP_005253887
          Length = 329

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DSETVQAIQ 9
           D+E V A+Q
Sbjct: 254 DTEAVSAVQ 262
>XP_006711900
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273381
          Length = 1732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273380
          Length = 1751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273379
          Length = 1754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_006711899
          Length = 1770

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273378
          Length = 1781

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273377
          Length = 1794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_006711898
          Length = 1797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_006711897
          Length = 1816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273375
          Length = 1829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005273374
          Length = 1832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   SETVQAIQ 9
           ++TVQA+Q
Sbjct: 466 TQTVQALQ 473
>XP_005245308
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSETV+ I
Sbjct: 126 DSETVENI 133
>XP_006711439
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSETVQAI 8
          DSETV+ I
Sbjct: 89 DSETVENI 96
>XP_006711438
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DSETVQAI 8
          DSETV+ I
Sbjct: 89 DSETVENI 96
>XP_006711437
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DSETVQAI 8
           DSETV+ I
Sbjct: 126 DSETVENI 133
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.110    0.251 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 400,152
Number of extensions: 687
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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