Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_848620                                                              17    3301
NP_002105                                                              17    4312
NP_001018081                                                           17    4312
XP_005249099                                                           17    4312
NP_057274                                                              16    5631
NP_001070911                                                           16    5631
NP_001070910                                                           16    5631
NP_112604                                                              16    5631
NP_004491                                                              16    5631
NP_064578                                                              16    5631
NP_060102                                                              16    5631
XP_006726463                                                           16    5631
XP_006720189                                                           16    5631
XP_006720188                                                           16    5631
XP_006720187                                                           16    5631
XP_006718701                                                           16    5631
XP_005274169                                                           16    5631
XP_005274166                                                           16    5631
XP_005274165                                                           16    5631
XP_005274163                                                           16    5631
XP_006712963                                                           16    5631
XP_006711409                                                           16    5631
XP_006710204                                                           16    5631
NP_001006640                                                           16    7355
NP_004771                                                              16    7355
NP_001006641                                                           16    7355
NP_057417                                                              16    7355
XP_005255284                                                           16    7355
XP_005255283                                                           16    7355
XP_006720936                                                           16    7355
XP_006720935                                                           16    7355
XP_005255282                                                           16    7355
NP_001036111                                                           15    9605
NP_001096080                                                           15    9605
NP_443135                                                              15    9605
NP_001070863                                                           15    9605
NP_001070862                                                           15    9605
NP_005376                                                              15    9605
NP_057042                                                              15    9605
XP_006725237                                                           15    9605
XP_005272597                                                           15    9605
XP_005265233                                                           15    9605
XP_005265231                                                           15    9605
XP_006713237                                                           15    9605
XP_006713236                                                           15    9605
XP_006713235                                                           15    9605
XP_006713234                                                           15    9605
XP_005265230                                                           15    9605
XP_005265016                                                           15    9605
XP_005265015                                                           15    9605
XP_005265014                                                           15    9605
XP_005265013                                                           15    9605
XP_006710746                                                           15    9605
XP_005270998                                                           15    9605
XP_005270996                                                           15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DRSSESQSS 9
            DRSS+SQSS
Sbjct: 1758 DRSSKSQSS 1766
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DRSSESQSS 9
            DRSS+SQSS
Sbjct: 1758 DRSSKSQSS 1766
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DRSSESQSS 9
            DRSS+SQSS
Sbjct: 1711 DRSSKSQSS 1719
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DRSSESQSS 9
            DRSS+SQSS
Sbjct: 1790 DRSSKSQSS 1798
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DRSSESQSS 9
            DRSS+SQSS
Sbjct: 1790 DRSSKSQSS 1798
>NP_848620
          Length = 416

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2  RSSESQSS 9
          +SSESQSS
Sbjct: 7  KSSESQSS 14
>NP_002105
          Length = 2718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DRSSESQS 8
           DRS+ESQ+
Sbjct: 549 DRSAESQA 556
>NP_001018081
          Length = 1309

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DRSSESQSS 9
           +RS+E+QSS
Sbjct: 236 ERSTETQSS 244
>XP_005249099
          Length = 2026

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DRSSESQS 8
           DRS+ESQ+
Sbjct: 549 DRSAESQA 556
>NP_057274
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           DR +ESQS
Sbjct: 168 DRQAESQS 175
>NP_001070911
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 218 DKSEEEQSS 226
>NP_001070910
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 231 DKSEEEQSS 239
>NP_112604
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 231 DKSEEEQSS 239
>NP_004491
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 218 DKSEEEQSS 226
>NP_064578
          Length = 1322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 764 DVSSESQSA 772
>NP_060102
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           DRS  SQSS
Sbjct: 207 DRSVSSQSS 215
>XP_006726463
          Length = 119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 8  EKSSEGQSS 16
>XP_006720189
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 218 DKSEEEQSS 226
>XP_006720188
          Length = 293

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 218 DKSEEEQSS 226
>XP_006720187
          Length = 301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRSSESQSS 9
           D+S E QSS
Sbjct: 231 DKSEEEQSS 239
>XP_006718701
          Length = 1309

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 765 DVSSESQSA 773
>XP_005274169
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 728 DVSSESQSA 736
>XP_005274166
          Length = 1323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 779 DVSSESQSA 787
>XP_005274165
          Length = 1323

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 765 DVSSESQSA 773
>XP_005274163
          Length = 1337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DRSSESQSS 9
           D SSESQS+
Sbjct: 779 DVSSESQSA 787
>XP_006712963
          Length = 119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 8  EKSSEGQSS 16
>XP_006711409
          Length = 495

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           DR +ESQS
Sbjct: 168 DRQAESQS 175
>XP_006710204
          Length = 119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 8  EKSSEGQSS 16
>NP_001006640
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 36 EQSSEEQSS 44
>NP_004771
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 36 EQSSEEQSS 44
>NP_001006641
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DRSSESQSS 9
          ++SSE QSS
Sbjct: 36 EQSSEEQSS 44
>NP_057417
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1789 DRSGSSQST 1797
>XP_005255284
          Length = 2581

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1789 DRSGSSQST 1797
>XP_005255283
          Length = 2751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1789 DRSGSSQST 1797
>XP_006720936
          Length = 2751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1788 DRSGSSQST 1796
>XP_006720935
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1789 DRSGSSQST 1797
>XP_005255282
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DRSSESQSS 9
            DRS  SQS+
Sbjct: 1789 DRSGSSQST 1797
>NP_001036111
          Length = 953

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSSESQS 8
           RSSESQ+
Sbjct: 828 RSSESQT 834
>NP_001096080
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 672 DRSSES 677
>NP_443135
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 672 DRSSES 677
>NP_001070863
          Length = 284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 273 ENSSESQS 280
>NP_001070862
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 274 ENSSESQS 281
>NP_005376
          Length = 1462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 683 DRSSES 688
>NP_057042
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 274 ENSSESQS 281
>XP_006725237
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 526 DRSSES 531
>XP_005272597
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 673 DRSSES 678
>XP_005265233
          Length = 1163

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 383 DRSSES 388
>XP_005265231
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 430 DRSSES 435
>XP_006713237
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 573 DRSSES 578
>XP_006713236
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 573 DRSSES 578
>XP_006713235
          Length = 1353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 573 DRSSES 578
>XP_006713234
          Length = 1436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 683 DRSSES 688
>XP_005265230
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DRSSES 6
           DRSSES
Sbjct: 683 DRSSES 688
>XP_005265016
          Length = 849

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSSESQS 8
           RSSESQ+
Sbjct: 724 RSSESQT 730
>XP_005265015
          Length = 879

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSSESQS 8
           RSSESQ+
Sbjct: 754 RSSESQT 760
>XP_005265014
          Length = 895

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSSESQS 8
           RSSESQ+
Sbjct: 770 RSSESQT 776
>XP_005265013
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RSSESQS 8
           RSSESQ+
Sbjct: 807 RSSESQT 813
>XP_006710746
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 153 ENSSESQS 160
>XP_005270998
          Length = 164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 153 ENSSESQS 160
>XP_005270996
          Length = 172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRSSESQS 8
           + SSESQS
Sbjct: 161 ENSSESQS 168
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.261   0.0817    0.165 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 261,137
Number of extensions: 315
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 19 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.2 bits)
S2: 28 (15.4 bits)

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