Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001460                                                              18    1935
NP_001275906                                                           18    1935
NP_001275905                                                           18    1935
NP_001275907                                                           18    1935
NP_001182036                                                           17    3301
NP_112218                                                              17    3301
NP_001182035                                                           17    3301
NP_001017388                                                           17    3301
NP_001182037                                                           17    3301
XP_006714095                                                           17    3301
XP_006714094                                                           17    3301
NP_002966                                                              17    4312
NP_060009                                                              17    4312
XP_006721125                                                           17    4312
NP_004374                                                              16    5631
NP_001120662                                                           16    5631
NP_000085                                                              16    5631
NP_060626                                                              16    5631
NP_056193                                                              16    5631
XP_005254222                                                           16    5631
XP_006711547                                                           16    5631
NP_941374                                                              16    7355
NP_065682                                                              16    7355
NP_001036128                                                           16    7355
NP_001036130                                                           16    7355
NP_001036129                                                           16    7355
NP_001252522                                                           16    7355
NP_001252521                                                           16    7355
NP_001252523                                                           16    7355
NP_110390                                                              16    7355
XP_006724753                                                           16    7355
XP_006724752                                                           16    7355
XP_006724751                                                           16    7355
NP_001273763                                                           15    9605
NP_002927                                                              15    9605
NP_079203                                                              15    9605
NP_003025                                                              15    9605
XP_006722160                                                           15    9605
XP_006722159                                                           15    9605
XP_005253526                                                           15    9605
NP_061720                                                              15    9605
>NP_001460
          Length = 609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DRRETGLFL 9
           D R+TG+FL
Sbjct: 192 DLRDTGIFL 200
>NP_001275906
          Length = 568

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DRRETGLFL 9
           D R+TG+FL
Sbjct: 151 DLRDTGIFL 159
>NP_001275905
          Length = 609

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DRRETGLFL 9
           D R+TG+FL
Sbjct: 192 DLRDTGIFL 200
>NP_001275907
          Length = 559

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DRRETGLFL 9
           D R+TG+FL
Sbjct: 142 DLRDTGIFL 150
>NP_001182036
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 760 DRRKCGLF 767
>NP_112218
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 760 DRRKCGLF 767
>NP_001182035
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 760 DRRKCGLF 767
>NP_001017388
          Length = 811

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 760 DRRKCGLF 767
>NP_001182037
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 746 DRRKCGLF 753
>XP_006714095
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 746 DRRKCGLF 753
>XP_006714094
          Length = 797

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DRRETGLF 8
           DRR+ GLF
Sbjct: 746 DRRKCGLF 753
>NP_002966
          Length = 323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRRETGLFL 9
           DRR  GL+L
Sbjct: 244 DRRAEGLYL 252
>NP_060009
          Length = 4116

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DRRETGLF 8
            DRR  GLF
Sbjct: 2121 DRRRKGLF 2128
>XP_006721125
          Length = 4070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DRRETGLF 8
            DRR  GLF
Sbjct: 2075 DRRRKGLF 2082
>NP_004374
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ETGLFL 9
           ETGLFL
Sbjct: 100 ETGLFL 105
>NP_001120662
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ETGLFL 9
           ETGLFL
Sbjct: 100 ETGLFL 105
>NP_000085
          Length = 2944

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   RRETGL 7
           RRETGL
Sbjct: 449 RRETGL 454
>NP_060626
          Length = 4363

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DRRETGLF 8
            +R+E GLF
Sbjct: 1587 ERKENGLF 1594
>NP_056193
          Length = 4388

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DRRETGLF 8
            +R+E GLF
Sbjct: 1587 ERKENGLF 1594
>XP_005254222
          Length = 450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   ETGLFL 9
           ETGLFL
Sbjct: 100 ETGLFL 105
>XP_006711547
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  DRRETGL 7
          DRR TGL
Sbjct: 32 DRRATGL 38
>NP_941374
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRRETGLFL 9
           DR+ TGL L
Sbjct: 128 DRKSTGLKL 136
>NP_065682
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DRRETGLFL 9
          DR+ TGL L
Sbjct: 51 DRKSTGLKL 59
>NP_001036128
          Length = 1062

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRRETGLFL 9
           DR+ TGL L
Sbjct: 107 DRKSTGLKL 115
>NP_001036130
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DRRETGLFL 9
          DR+ TGL L
Sbjct: 51 DRKSTGLKL 59
>NP_001036129
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DRRETGLFL 9
          DR+ TGL L
Sbjct: 51 DRKSTGLKL 59
>NP_001252522
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRRETGLFL 9
           DR+ TGL L
Sbjct: 120 DRKSTGLKL 128
>NP_001252521
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRRETGLFL 9
           DR+ TGL L
Sbjct: 130 DRKSTGLKL 138
>NP_001252523
          Length = 930

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DRRETGLFL 9
          DR+ TGL L
Sbjct: 51 DRKSTGLKL 59
>NP_110390
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DRRETG 6
           DR+ETG
Sbjct: 201 DRKETG 206
>XP_006724753
          Length = 272

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DRRETG 6
           DR+ETG
Sbjct: 191 DRKETG 196
>XP_006724752
          Length = 273

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DRRETG 6
           DR+ETG
Sbjct: 192 DRKETG 197
>XP_006724751
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DRRETG 6
           DR+ETG
Sbjct: 202 DRKETG 207
>NP_001273763
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RETGLFL 9
          R+TG+FL
Sbjct: 9  RKTGVFL 15
>NP_002927
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  RETGLFL 9
          R+TG+FL
Sbjct: 35 RKTGVFL 41
>NP_079203
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRETGLF 8
           R+ETGL+
Sbjct: 160 RKETGLW 166
>NP_003025
          Length = 356

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRETGLFL 9
           R  TGLFL
Sbjct: 272 RLSTGLFL 279
>XP_006722160
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRETGLF 8
           R+ETGL+
Sbjct: 160 RKETGLW 166
>XP_006722159
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RRETGLF 8
           R+ETGL+
Sbjct: 160 RKETGLW 166
>XP_005253526
          Length = 213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RRETGLFL 9
           R  TGLFL
Sbjct: 129 RLSTGLFL 136
>NP_061720
          Length = 4024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   RETGLFL 9
           RETG F+
Sbjct: 923 RETGTFI 929
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.154    0.446 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 527,935
Number of extensions: 734
Number of successful extensions: 41
Number of sequences better than 10000.0: 41
Number of HSP's gapped: 41
Number of HSP's successfully gapped: 41
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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