Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              18    1135
NP_001030312                                                           17    4312
NP_003267                                                              16    5631
NP_001001389                                                           16    5631
XP_005253297                                                           16    5631
XP_005253292                                                           16    5631
NP_085153                                                              16    7355
NP_065996                                                              16    7355
XP_005270063                                                           16    7355
XP_005270062                                                           16    7355
XP_005270061                                                           16    7355
XP_005246937                                                           16    7355
XP_005246936                                                           16    7355
XP_006712846                                                           16    7355
NP_620706                                                              15    9605
NP_003066                                                              15    9605
NP_001123892                                                           15    9605
NP_998760                                                              15    9605
NP_001001390                                                           15    9605
NP_000601                                                              15    9605
NP_001189485                                                           15    9605
NP_057016                                                              15    9605
NP_001186308                                                           15    9605
NP_001008537                                                           15    9605
NP_056265                                                              15    9605
NP_001186307                                                           15    9605
NP_001036059                                                           15    9605
NP_001073890                                                           15    9605
NP_004184                                                              15    9605
XP_006724709                                                           15    9605
XP_006724708                                                           15    9605
XP_005260721                                                           15    9605
XP_006722755                                                           15    9605
XP_005269161                                                           15    9605
XP_005269160                                                           15    9605
XP_005269159                                                           15    9605
XP_005269158                                                           15    9605
XP_005268818                                                           15    9605
XP_005268817                                                           15    9605
XP_006718453                                                           15    9605
XP_005253296                                                           15    9605
XP_005253291                                                           15    9605
XP_005253290                                                           15    9605
XP_006718452                                                           15    9605
XP_006718451                                                           15    9605
XP_005253289                                                           15    9605
XP_005253288                                                           15    9605
XP_006718114                                                           15    9605
XP_005270318                                                           15    9605
XP_006718113                                                           15    9605
XP_006718112                                                           15    9605
XP_006718111                                                           15    9605
XP_006718110                                                           15    9605
XP_006715980                                                           15    9605
NP_001009608                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DRIPASEIS 9
           D IPASEIS
Sbjct: 916 DGIPASEIS 924
>NP_001030312
          Length = 236

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RIPASEIS 9
          R+PASE S
Sbjct: 62 RVPASETS 69
>NP_003267
          Length = 694

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DRIPASEIS 9
           D+I ASE+S
Sbjct: 483 DKIDASELS 491
>NP_001001389
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           DRIPA+  S
Sbjct: 217 DRIPATSTS 225
>XP_005253297
          Length = 535

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           DRIPA+  S
Sbjct: 217 DRIPATSTS 225
>XP_005253292
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           DRIPA+  S
Sbjct: 217 DRIPATSTS 225
>NP_085153
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D+IPA+E
Sbjct: 368 DKIPATE 374
>NP_065996
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           D +PA E+S
Sbjct: 277 DTLPAPEVS 285
>XP_005270063
          Length = 2005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           D +PA E+S
Sbjct: 277 DTLPAPEVS 285
>XP_005270062
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           D +PA E+S
Sbjct: 277 DTLPAPEVS 285
>XP_005270061
          Length = 3184

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           D +PA E+S
Sbjct: 277 DTLPAPEVS 285
>XP_005246937
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D+IPA+E
Sbjct: 250 DKIPATE 256
>XP_005246936
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D+IPA+E
Sbjct: 293 DKIPATE 299
>XP_006712846
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D+IPA+E
Sbjct: 368 DKIPATE 374
>NP_620706
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>NP_003066
          Length = 1214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>NP_001123892
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>NP_998760
          Length = 167

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RIPASEIS 9
          R+PA E+S
Sbjct: 22 RLPARELS 29
>NP_001001390
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATNM 224
>NP_000601
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>NP_001189485
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DRIPASEIS 9
           DRIPA+  S
Sbjct: 217 DRIPATRHS 225
>NP_057016
          Length = 141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DRIPASEIS 9
          D IP +E+S
Sbjct: 12 DSIPVTELS 20
>NP_001186308
          Length = 1855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1847 DPIPTSEVN 1855
>NP_001008537
          Length = 1516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RIPASEIS 9
           RIP+ EIS
Sbjct: 640 RIPSIEIS 647
>NP_056265
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIPASEI 8
           +IPASE+
Sbjct: 567 QIPASEV 573
>NP_001186307
          Length = 1856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1848 DPIPTSEVN 1856
>NP_001036059
          Length = 503

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIPASEI 8
           +IPASE+
Sbjct: 436 QIPASEV 442
>NP_001073890
          Length = 1703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D++PA+E
Sbjct: 409 DKVPAAE 415
>NP_004184
          Length = 1859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1851 DPIPTSEVN 1859
>XP_006724709
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RIPASEIS 9
           RIP+ EIS
Sbjct: 640 RIPSIEIS 647
>XP_006724708
          Length = 1486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RIPASEIS 9
           RIP+ EIS
Sbjct: 640 RIPSIEIS 647
>XP_005260721
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IPASEIS 9
           +PASE+S
Sbjct: 169 LPASELS 175
>XP_006722755
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DRIPASE 7
           D++PA+E
Sbjct: 409 DKVPAAE 415
>XP_005269161
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>XP_005269160
          Length = 1213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>XP_005269159
          Length = 1244

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>XP_005269158
          Length = 1245

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   IPASEI 8
           IPASEI
Sbjct: 216 IPASEI 221
>XP_005268818
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RIPASEIS 9
          R+PA E+S
Sbjct: 22 RLPARELS 29
>XP_005268817
          Length = 156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RIPASEIS 9
          R+PA E+S
Sbjct: 22 RLPARELS 29
>XP_006718453
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_005253296
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_005253291
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_005253290
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_006718452
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_006718451
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_005253289
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_005253288
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIPASEI 8
           DRIPA+ +
Sbjct: 217 DRIPATTL 224
>XP_006718114
          Length = 1850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1842 DPIPTSEVN 1850
>XP_005270318
          Length = 1860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1852 DPIPTSEVN 1860
>XP_006718113
          Length = 1881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1873 DPIPTSEVN 1881
>XP_006718112
          Length = 1889

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1881 DPIPTSEVN 1889
>XP_006718111
          Length = 1892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1884 DPIPTSEVN 1892
>XP_006718110
          Length = 1893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    DRIPASEIS 9
            D IP SE++
Sbjct: 1885 DPIPTSEVN 1893
>XP_006715980
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RIPASEI 8
           +IPASE+
Sbjct: 567 QIPASEV 573
>NP_001009608
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IPASEIS 9
           +PASE+S
Sbjct: 334 LPASELS 340
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.126    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 616,396
Number of extensions: 815
Number of successful extensions: 55
Number of sequences better than 10000.0: 55
Number of HSP's gapped: 55
Number of HSP's successfully gapped: 55
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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