Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
NP_005422                                                              16    5631
NP_001177                                                              16    7355
NP_996749                                                              16    7355
NP_001138863                                                           16    7355
NP_060367                                                              16    7355
NP_004730                                                              16    7355
XP_006724097                                                           16    7355
XP_005261071                                                           16    7355
XP_005261070                                                           16    7355
XP_005261069                                                           16    7355
XP_006713279                                                           16    7355
NP_115532                                                              15    9605
NP_076414                                                              15    9605
NP_001002259                                                           15    9605
NP_201591                                                              15    9605
NP_001480                                                              15    9605
NP_001265475                                                           15    9605
NP_653271                                                              15    9605
NP_115583                                                              15    9605
NP_001193785                                                           15    9605
NP_001275763                                                           15    9605
NP_001167560                                                           15    9605
NP_036221                                                              15    9605
NP_001269353                                                           15    9605
NP_114423                                                              15    9605
NP_001167561                                                           15    9605
XP_005260914                                                           15    9605
XP_005260913                                                           15    9605
XP_006722983                                                           15    9605
XP_006719210                                                           15    9605
XP_006719209                                                           15    9605
XP_006719208                                                           15    9605
XP_006719207                                                           15    9605
XP_006719206                                                           15    9605
XP_006719205                                                           15    9605
XP_006719204                                                           15    9605
XP_006719203                                                           15    9605
XP_006719202                                                           15    9605
XP_006719201                                                           15    9605
XP_006719200                                                           15    9605
XP_005251975                                                           15    9605
XP_005251974                                                           15    9605
XP_006711818                                                           15    9605
XP_006711817                                                           15    9605
NP_001130005                                                           15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DRIMSGES 8
            DRIMSGES
Sbjct: 1051 DRIMSGES 1058
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DRIMSGES 8
            DRIMSGES
Sbjct: 1181 DRIMSGES 1188
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   DRIMSGES 8
           DRIMSGES
Sbjct: 879 DRIMSGES 886
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   DRIMSGES 8
           DRIMSGES
Sbjct: 879 DRIMSGES 886
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DRIMSGES 8
            DRIMSGES
Sbjct: 1082 DRIMSGES 1089
>NP_005422
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+  GES+
Sbjct: 158 DRVNGGESV 166
>NP_001177
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>NP_996749
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>NP_001138863
          Length = 376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DRIMSGES 8
          DR++ GES
Sbjct: 64 DRLIGGES 71
>NP_060367
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DRIMSGES 8
          DR++ GES
Sbjct: 64 DRLIGGES 71
>NP_004730
          Length = 668

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR++ GES
Sbjct: 159 DRLVEGES 166
>XP_006724097
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>XP_005261071
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>XP_005261070
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>XP_005261069
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DRIMSGES 8
           DR+ +GES
Sbjct: 237 DRVRTGES 244
>XP_006713279
          Length = 459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DRIMSGES 8
          DR++ GES
Sbjct: 64 DRLIGGES 71
>NP_115532
          Length = 960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>NP_076414
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>NP_001002259
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>NP_201591
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIMSGE 7
           +RIMSG+
Sbjct: 154 ERIMSGQ 160
>NP_001480
          Length = 475

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIMSGE 7
           +RIMSG+
Sbjct: 150 ERIMSGQ 156
>NP_001265475
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIMSGE 7
           +RIMSG+
Sbjct: 150 ERIMSGQ 156
>NP_653271
          Length = 1454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    IMSGESI 9
            I+SGESI
Sbjct: 1165 IISGESI 1171
>NP_115583
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DRIMSGESI 9
           DRI+SG ++
Sbjct: 132 DRILSGGAL 140
>NP_001193785
          Length = 905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>NP_001275763
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DRIMSGESI 9
           DRI+SG ++
Sbjct: 132 DRILSGGAL 140
>NP_001167560
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  IMSGESI 9
          I+SGESI
Sbjct: 59 IVSGESI 65
>NP_036221
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+M G ++
Sbjct: 677 DRLMDGRTV 685
>NP_001269353
          Length = 963

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IMSGESI 9
           I+SGESI
Sbjct: 674 IISGESI 680
>NP_114423
          Length = 891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  IMSGESI 9
          I+SGESI
Sbjct: 75 IVSGESI 81
>NP_001167561
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IMSGESI 9
           I+SGESI
Sbjct: 102 IVSGESI 108
>XP_005260914
          Length = 856

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  IMSGESI 9
          I+SGESI
Sbjct: 40 IVSGESI 46
>XP_005260913
          Length = 998

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IMSGESI 9
           I+SGESI
Sbjct: 220 IVSGESI 226
>XP_006722983
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DRIMSGESI 9
           DRI+SG ++
Sbjct: 132 DRILSGGAL 140
>XP_006719210
          Length = 940

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719209
          Length = 941

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719208
          Length = 961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719207
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719206
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DRIMSGESI 9
          DR+ SGE +
Sbjct: 67 DRLKSGEHL 75
>XP_006719205
          Length = 1057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719204
          Length = 1078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719203
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719202
          Length = 1092

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719201
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_006719200
          Length = 1126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+ SGE +
Sbjct: 148 DRLKSGEHL 156
>XP_005251975
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIMSGE 7
           +RIMSG+
Sbjct: 112 ERIMSGQ 118
>XP_005251974
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DRIMSGE 7
           +RIMSG+
Sbjct: 154 ERIMSGQ 160
>XP_006711818
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+M G ++
Sbjct: 498 DRLMDGRTV 506
>XP_006711817
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DRIMSGESI 9
           DR+M G ++
Sbjct: 498 DRLMDGRTV 506
>NP_001130005
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IMSGESI 9
           +MSGES+
Sbjct: 94  LMSGESL 100
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.133    0.335 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 530,509
Number of extensions: 868
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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