Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              22     134
XP_006716142                                                           22     134
XP_005250088                                                           22     134
XP_006716141                                                           22     134
XP_005250085                                                           22     134
XP_006716140                                                           22     134
XP_005250084                                                           22     134
XP_005250083                                                           22     134
XP_005250082                                                           22     134
NP_001094092                                                           17    2528
NP_001275699                                                           17    2528
NP_001094091                                                           17    2528
NP_060411                                                              17    2528
NP_001275700                                                           17    2528
XP_006722029                                                           17    2528
XP_005257544                                                           17    2528
NP_665682                                                              16    5631
NP_149353                                                              16    5631
NP_149355                                                              16    5631
NP_149354                                                              16    5631
NP_006110                                                              16    5631
NP_001193318                                                           16    5631
NP_001136028                                                           16    5631
NP_036616                                                              16    5631
NP_001136029                                                           16    5631
NP_036617                                                              16    5631
NP_001188410                                                           16    5631
NP_115912                                                              16    5631
NP_001188411                                                           16    5631
NP_001188409                                                           16    5631
XP_006712295                                                           16    5631
XP_006712294                                                           16    5631
NP_005236                                                              16    7355
NP_078813                                                              16    7355
NP_775823                                                              16    7355
NP_001127942                                                           16    7355
XP_006720016                                                           16    7355
XP_006714202                                                           16    7355
XP_005262892                                                           16    7355
XP_005262891                                                           16    7355
NP_002022                                                              15    9605
NP_689961                                                              15    9605
NP_001136221                                                           15    9605
NP_079114                                                              15    9605
XP_005252654                                                           15    9605
XP_006715958                                                           15    9605
XP_006715957                                                           15    9605
XP_005266938                                                           15    9605
XP_005266939                                                           15    9605
XP_005266937                                                           15    9605
>NP_733751
          Length = 4911

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1896 DPYAKMVG 1903
>XP_006716142
          Length = 4927

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_005250088
          Length = 4928

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_006716141
          Length = 4959

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_005250085
          Length = 4979

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_006716140
          Length = 4982

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_005250084
          Length = 4982

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>XP_005250083
          Length = 4982

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1912 DPYAKMVG 1919
>XP_005250082
          Length = 4983

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DPYAKMVG 8
            DPYAKMVG
Sbjct: 1913 DPYAKMVG 1920
>NP_001094092
          Length = 583

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>NP_001275699
          Length = 573

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>NP_001094091
          Length = 573

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>NP_060411
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>NP_001275700
          Length = 547

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>XP_006722029
          Length = 547

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>XP_005257544
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  PYAKMVG 8
          PY KM+G
Sbjct: 26 PYCKMIG 32
>NP_665682
          Length = 938

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 624 DPYERMV 630
>NP_149353
          Length = 244

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DPYAKMV 7
           DP+AK++
Sbjct: 110 DPFAKLI 116
>NP_149355
          Length = 204

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  DPYAKMV 7
          DP+AK++
Sbjct: 70 DPFAKLI 76
>NP_149354
          Length = 233

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DPYAKMV 7
           DP+AK++
Sbjct: 99  DPFAKLI 105
>NP_006110
          Length = 215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  DPYAKMV 7
          DP+AK++
Sbjct: 81 DPFAKLI 87
>NP_001193318
          Length = 140

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  DPYAKMV 7
          DP+AK++
Sbjct: 6  DPFAKLI 12
>NP_001136028
          Length = 725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DPYAKMVG 8
           D YAK++G
Sbjct: 624 DSYAKLLG 631
>NP_036616
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DPYAKMVG 8
           D YAK++G
Sbjct: 623 DSYAKLLG 630
>NP_001136029
          Length = 638

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DPYAKMVG 8
           D YAK++G
Sbjct: 537 DSYAKLLG 544
>NP_036617
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DPYAKMVG 8
           D YAK++G
Sbjct: 608 DSYAKLLG 615
>NP_001188410
          Length = 903

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 589 DPYERMV 595
>NP_115912
          Length = 934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 620 DPYERMV 626
>NP_001188411
          Length = 898

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 584 DPYERMV 590
>NP_001188409
          Length = 959

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 645 DPYERMV 651
>XP_006712295
          Length = 923

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 609 DPYERMV 615
>XP_006712294
          Length = 928

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DPYAKMV 7
           DPY +MV
Sbjct: 614 DPYERMV 620
>NP_005236
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DPYAKMVG 8
            DP A M+G
Sbjct: 1371 DPVAHMIG 1378
>NP_078813
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DPYAKMVG 8
           D Y K+VG
Sbjct: 202 DKYGKLVG 209
>NP_775823
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PYAKMVGA 9
           P+AK +GA
Sbjct: 228 PFAKYLGA 235
>NP_001127942
          Length = 221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  PYAKMVGA 9
          P+AK +GA
Sbjct: 19 PFAKYLGA 26
>XP_006720016
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DPYAKMVG 8
          D Y K+VG
Sbjct: 89 DKYGKLVG 96
>XP_006714202
          Length = 4588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DPYAKMVG 8
            DP A M+G
Sbjct: 1371 DPVAHMIG 1378
>XP_005262892
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DPYAKMVG 8
            DP A M+G
Sbjct: 1371 DPVAHMIG 1378
>XP_005262891
          Length = 4600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DPYAKMVG 8
            DP A M+G
Sbjct: 1371 DPVAHMIG 1378
>NP_002022
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PYAKMVGA 9
           PY+ M GA
Sbjct: 433 PYSGMTGA 440
>NP_689961
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DPYAKMVGA 9
           D Y  +VGA
Sbjct: 580 DDYTNLVGA 588
>NP_001136221
          Length = 1029

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DPYAKMVGA 9
           D Y  +VGA
Sbjct: 747 DDYTNLVGA 755
>NP_079114
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YAKMVG 8
           YAKM+G
Sbjct: 519 YAKMMG 524
>XP_005252654
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   YAKMVG 8
           YAKM+G
Sbjct: 519 YAKMMG 524
>XP_006715958
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DPYAKMVGA 9
           D Y  +VGA
Sbjct: 633 DDYTNLVGA 641
>XP_006715957
          Length = 915

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DPYAKMVGA 9
           D Y  +VGA
Sbjct: 633 DDYTNLVGA 641
>XP_005266938
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PYAKMVGA 9
           PY+ M GA
Sbjct: 433 PYSGMTGA 440
>XP_005266939
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PYAKMVGA 9
           PY+ M GA
Sbjct: 433 PYSGMTGA 440
>XP_005266937
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   PYAKMVGA 9
           PY+ M GA
Sbjct: 433 PYSGMTGA 440
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.134    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 575,293
Number of extensions: 1049
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package