Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              20     509
NP_001035957                                                           20     509
XP_006721991                                                           20     509
XP_006721990                                                           20     509
XP_006721989                                                           20     509
XP_005258041                                                           20     509
XP_006721988                                                           20     509
XP_006721987                                                           20     509
XP_006721986                                                           20     509
XP_005258040                                                           20     509
XP_006721985                                                           20     509
NP_001005493                                                           17    3301
NP_705618                                                              17    3301
NP_004289                                                              17    3301
NP_001265241                                                           17    3301
NP_001229808                                                           17    4312
NP_001229807                                                           17    4312
NP_001229805                                                           17    4312
NP_001229806                                                           17    4312
NP_001229804                                                           17    4312
NP_060725                                                              17    4312
NP_036257                                                              16    5631
NP_001005490                                                           16    5631
NP_001070254                                                           16    5631
XP_005254198                                                           16    5631
XP_006718388                                                           16    5631
XP_006718387                                                           16    5631
XP_006718386                                                           16    5631
NP_001136095                                                           16    7355
NP_001136094                                                           16    7355
NP_115873                                                              16    7355
NP_002579                                                              16    7355
NP_115778                                                              16    7355
NP_078934                                                              15    9605
NP_001230925                                                           15    9605
NP_055549                                                              15    9605
NP_001027                                                              15    9605
NP_653274                                                              15    9605
NP_001004695                                                           15    9605
>NP_000258
          Length = 2818

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1302 DPLLRIVIT 1310
>NP_001035957
          Length = 2839

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1302 DPLLRIVIT 1310
>XP_006721991
          Length = 1632

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>XP_006721990
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>XP_006721989
          Length = 2823

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>XP_005258041
          Length = 2836

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1302 DPLLRIVIT 1310
>XP_006721988
          Length = 2846

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>XP_006721987
          Length = 2849

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>XP_006721986
          Length = 2854

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1299 DPLLRIVIT 1307
>XP_005258040
          Length = 2857

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1302 DPLLRIVIT 1310
>XP_006721985
          Length = 2867

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DPLLQIVIT 9
            DPLL+IVIT
Sbjct: 1312 DPLLRIVIT 1320
>NP_001005493
          Length = 314

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  DPLLQIVI 8
          DP LQIVI
Sbjct: 18 DPQLQIVI 25
>NP_705618
          Length = 1391

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DPLLQIVI 8
           DP+LQI I
Sbjct: 277 DPILQIAI 284
>NP_004289
          Length = 1332

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DPLLQIVI 8
           DP+LQI I
Sbjct: 218 DPILQIAI 225
>NP_001265241
          Length = 1327

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DPLLQIVI 8
           DP+LQI I
Sbjct: 277 DPILQIAI 284
>NP_001229808
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_001229807
          Length = 756

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_001229805
          Length = 821

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_001229806
          Length = 800

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_001229804
          Length = 891

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_060725
          Length = 826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DPLLQIVIT 9
          DPL ++V+T
Sbjct: 44 DPLKRVVVT 52
>NP_036257
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DPLLQIV 7
           DP+LQ+V
Sbjct: 318 DPVLQVV 324
>NP_001005490
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DPLLQIVI 8
          DP LQ++I
Sbjct: 18 DPQLQVII 25
>NP_001070254
          Length = 1735

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DPLLQI 6
           DPLLQI
Sbjct: 97  DPLLQI 102
>XP_005254198
          Length = 532

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DPLLQIV 7
           DP+LQ+V
Sbjct: 318 DPVLQVV 324
>XP_006718388
          Length = 1331

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DPLLQI 6
           DPLLQI
Sbjct: 160 DPLLQI 165
>XP_006718387
          Length = 1798

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DPLLQI 6
           DPLLQI
Sbjct: 160 DPLLQI 165
>XP_006718386
          Length = 1822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DPLLQI 6
           DPLLQI
Sbjct: 160 DPLLQI 165
>NP_001136095
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PLLQIVIT 9
           P LQ+V+T
Sbjct: 257 PKLQVVVT 264
>NP_001136094
          Length = 491

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PLLQIVIT 9
           P LQ+V+T
Sbjct: 218 PKLQVVVT 225
>NP_115873
          Length = 530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PLLQIVIT 9
           P LQ+V+T
Sbjct: 257 PKLQVVVT 264
>NP_002579
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DPLLQIVIT 9
           +P LQ+V+T
Sbjct: 207 EPSLQLVLT 215
>NP_115778
          Length = 863

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DPLLQIVIT 9
           +P LQ+V+T
Sbjct: 207 EPSLQLVLT 215
>NP_078934
          Length = 1081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   PLLQIV 7
           PLLQIV
Sbjct: 394 PLLQIV 399
>NP_001230925
          Length = 4865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DPLLQIVI 8
            DPL QI++
Sbjct: 3546 DPLHQIIL 3553
>NP_055549
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DPLLQIVIT 9
           DP +QIV++
Sbjct: 193 DPRVQIVLS 201
>NP_001027
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DPLLQIVI 8
            DPL QI++
Sbjct: 3551 DPLHQIIL 3558
>NP_653274
          Length = 248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   PLLQIVIT 9
           P+L+++IT
Sbjct: 112 PILRLIIT 119
>NP_001004695
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DPLLQIVIT 9
           D LLQ V+T
Sbjct: 153 DGLLQAVVT 161
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.153    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 480,494
Number of extensions: 698
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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