Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              21     175
XP_006716142                                                           21     175
XP_005250088                                                           21     175
XP_006716141                                                           21     175
XP_005250085                                                           21     175
XP_006716140                                                           21     175
XP_005250084                                                           21     175
XP_005250083                                                           21     175
XP_005250082                                                           21     175
NP_113651                                                              17    2528
XP_005256246                                                           17    2528
XP_005252782                                                           17    3301
XP_006718182                                                           17    3301
XP_006714215                                                           17    3301
XP_006714214                                                           17    3301
XP_005262915                                                           17    3301
NP_055806                                                              17    3301
NP_060115                                                              16    5631
NP_001257819                                                           16    5631
NP_001070993                                                           16    5631
NP_001121646                                                           16    5631
NP_001032903                                                           16    5631
NP_071930                                                              16    5631
XP_005259877                                                           16    5631
XP_006714366                                                           16    5631
XP_006714365                                                           16    5631
XP_005265457                                                           16    5631
NP_001070994                                                           16    5631
NP_055790                                                              16    5631
NP_003351                                                              16    5631
NP_065988                                                              16    7355
NP_006089                                                              16    7355
NP_065120                                                              16    7355
NP_003310                                                              16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_058633                                                              16    7355
NP_659444                                                              16    7355
NP_116256                                                              16    7355
XP_005274609                                                           16    7355
XP_005258690                                                           16    7355
XP_005258689                                                           16    7355
XP_005267986                                                           16    7355
XP_005253235                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_000575                                                              15    9605
NP_004919                                                              15    9605
NP_001258369                                                           15    9605
NP_001258371                                                           15    9605
NP_001258370                                                           15    9605
NP_940892                                                              15    9605
NP_001191814                                                           15    9605
NP_001191813                                                           15    9605
NP_001265536                                                           15    9605
NP_001191815                                                           15    9605
NP_660288                                                              15    9605
NP_001191812                                                           15    9605
NP_002786                                                              15    9605
NP_001265537                                                           15    9605
NP_001265535                                                           15    9605
NP_001157915                                                           15    9605
NP_001186                                                              15    9605
NP_001153416                                                           15    9605
XP_006724116                                                           15    9605
XP_006724115                                                           15    9605
XP_006724114                                                           15    9605
XP_005272515                                                           15    9605
NP_001155177                                                           15    9605
NP_001092006                                                           15    9605
NP_003472                                                              15    9605
>NP_733751
          Length = 4911

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 861 DISEGREIF 869
>XP_006716142
          Length = 4927

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_005250088
          Length = 4928

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_006716141
          Length = 4959

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_005250085
          Length = 4979

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_006716140
          Length = 4982

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_005250084
          Length = 4982

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>XP_005250083
          Length = 4982

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 861 DISEGREIF 869
>XP_005250082
          Length = 4983

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DLSEGREIF 9
           D+SEGREIF
Sbjct: 862 DISEGREIF 870
>NP_113651
          Length = 330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLSEGREIF 9
           D S GREI+
Sbjct: 125 DFSSGREIY 133
>XP_005256246
          Length = 330

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLSEGREIF 9
           D S GREI+
Sbjct: 125 DFSSGREIY 133
>XP_005252782
          Length = 533

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLSEGREIF 9
           D  EGRE+F
Sbjct: 270 DHKEGRELF 278
>XP_006718182
          Length = 541

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLSEGREIF 9
           D  EGRE+F
Sbjct: 270 DHKEGRELF 278
>XP_006714215
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DLSEGREI 8
            D+SEGR++
Sbjct: 2206 DISEGRQL 2213
>XP_006714214
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DLSEGREI 8
            D+SEGR++
Sbjct: 2206 DISEGRQL 2213
>XP_005262915
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DLSEGREI 8
            D+SEGR++
Sbjct: 2206 DISEGRQL 2213
>NP_055806
          Length = 3526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DLSEGREI 8
            D+SEGR++
Sbjct: 2188 DISEGRQL 2195
>NP_060115
          Length = 955

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LSEGREI 8
           LSEG+EI
Sbjct: 555 LSEGKEI 561
>NP_001257819
          Length = 920

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LSEGREI 8
           LSEG+EI
Sbjct: 520 LSEGKEI 526
>NP_001070993
          Length = 650

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSEGREIF 9
           LS+G EIF
Sbjct: 383 LSKGEEIF 390
>NP_001121646
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LSEGREI 8
          LSEGR+I
Sbjct: 56 LSEGRDI 62
>NP_001032903
          Length = 574

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLS+G E+
Sbjct: 408 DLSQGHEV 415
>NP_071930
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSEGREIF 9
           LS+G EIF
Sbjct: 383 LSKGEEIF 390
>XP_005259877
          Length = 1394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLSEGR 6
           DLSEGR
Sbjct: 180 DLSEGR 185
>XP_006714366
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LSEGREI 8
          LSEGR+I
Sbjct: 56 LSEGRDI 62
>XP_006714365
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LSEGREI 8
          LSEGR+I
Sbjct: 56 LSEGRDI 62
>XP_005265457
          Length = 625

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSEGREIF 9
           LS+G EIF
Sbjct: 358 LSKGEEIF 365
>NP_001070994
          Length = 598

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LSEGREIF 9
           LS+G EIF
Sbjct: 383 LSKGEEIF 390
>NP_055790
          Length = 1570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLSEGR 6
           DLSEGR
Sbjct: 356 DLSEGR 361
>NP_003351
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LSEGREI 8
          LSEGR+I
Sbjct: 56 LSEGRDI 62
>NP_065988
          Length = 2048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LSEGRE 7
           LSEGRE
Sbjct: 589 LSEGRE 594
>NP_006089
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DLSEGREIF 9
           DL+EG+ ++
Sbjct: 220 DLNEGKHLY 228
>NP_065120
          Length = 213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLS+ RE+
Sbjct: 128 DLSQAREV 135
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 13447 DLTEGKE 13453
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 13572 DLTEGKE 13578
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 20871 DLTEGKE 20877
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 19944 DLTEGKE 19950
>NP_058633
          Length = 1462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LSEGREIF 9
          + +GREIF
Sbjct: 88 VEDGREIF 95
>NP_659444
          Length = 1033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGREI
Sbjct: 985 LKEGREI 991
>NP_116256
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLSEGREIF 9
           DL+E +E+F
Sbjct: 642 DLNEEQEVF 650
>XP_005274609
          Length = 1468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LSEGREIF 9
           + +GREIF
Sbjct: 94  VEDGREIF 101
>XP_005258690
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGREI
Sbjct: 468 LKEGREI 474
>XP_005258689
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGREI
Sbjct: 886 LKEGREI 892
>XP_005267986
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LSEGRE 7
           LSEGRE
Sbjct: 563 LSEGRE 568
>XP_005253235
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLSEGREIF 9
           DL+E +E+F
Sbjct: 643 DLNEEQEVF 651
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    DLSEGRE 7
            DL+EG+E
Sbjct: 9184 DLTEGKE 9190
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 10543 DLTEGKE 10549
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 20499 DLTEGKE 20505
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 22005 DLTEGKE 22011
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 22512 DLTEGKE 22518
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1     DLSEGRE 7
             DL+EG+E
Sbjct: 13639 DLTEGKE 13645
>NP_000575
          Length = 99

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LSEGREI 8
          LS+GRE+
Sbjct: 70 LSDGREL 76
>NP_004919
          Length = 256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 135 LSEGEEI 141
>NP_001258369
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 135 LSEGEEI 141
>NP_001258371
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 94  LSEGEEI 100
>NP_001258370
          Length = 375

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 135 LSEGEEI 141
>NP_940892
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLSE RE+
Sbjct: 134 DLSELREV 141
>NP_001191814
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLSE RE+
Sbjct: 134 DLSELREV 141
>NP_001191813
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLSE RE+
Sbjct: 134 DLSELREV 141
>NP_001265536
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGRE+
Sbjct: 114 LEEGREV 120
>NP_001191815
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLSE RE+
Sbjct: 134 DLSELREV 141
>NP_660288
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSEGREI 8
           L+EGRE+
Sbjct: 573 LAEGREL 579
>NP_001191812
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLSEGREI 8
           DLSE RE+
Sbjct: 134 DLSELREV 141
>NP_002786
          Length = 205

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DLSEGREI 8
          +L EGR+I
Sbjct: 75 ELKEGRQI 82
>NP_001265537
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LSEGREI 8
          L EGRE+
Sbjct: 86 LEEGREV 92
>NP_001265535
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  LSEGREI 8
          L EGRE+
Sbjct: 86 LEEGREV 92
>NP_001157915
          Length = 1873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DLSEGRE 7
           +LSEGR+
Sbjct: 150 ELSEGRD 156
>NP_001186
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGRE+
Sbjct: 225 LEEGREV 231
>NP_001153416
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSEGREI 8
           L+EGRE+
Sbjct: 584 LAEGREL 590
>XP_006724116
          Length = 148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  LSEGREI 8
          LSEG EI
Sbjct: 27 LSEGEEI 33
>XP_006724115
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 160 LSEGEEI 166
>XP_006724114
          Length = 281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           LSEG EI
Sbjct: 160 LSEGEEI 166
>XP_005272515
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   LSEGREI 8
           L+EGRE+
Sbjct: 584 LAEGREL 590
>NP_001155177
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LSEGREI 8
           L EGRE+
Sbjct: 100 LEEGREV 106
>NP_001092006
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLSEGR 6
           D+SEGR
Sbjct: 773 DISEGR 778
>NP_003472
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLSEGR 6
           D+SEGR
Sbjct: 750 DISEGR 755
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.146    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 642,622
Number of extensions: 1221
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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