Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              18    1482
XP_005273257                                                           18    1482
XP_006723285                                                           18    1935
XP_005259006                                                           18    1935
XP_005259005                                                           18    1935
NP_002437                                                              18    1935
NP_689805                                                              17    2528
NP_055795                                                              17    2528
XP_006720129                                                           17    2528
XP_006720128                                                           17    2528
XP_006720127                                                           17    2528
XP_006720126                                                           17    2528
XP_005267433                                                           17    2528
XP_005267434                                                           17    2528
XP_005247964                                                           17    2528
XP_006713889                                                           17    2528
XP_006713888                                                           17    2528
NP_001010859                                                           17    3301
XP_005261426                                                           17    3301
NP_115811                                                              16    5631
NP_059990                                                              16    5631
XP_005266493                                                           16    5631
XP_005266492                                                           16    5631
NP_061160                                                              16    5631
NP_112506                                                              16    7355
NP_640337                                                              16    7355
NP_001121187                                                           16    7355
NP_031371                                                              16    7355
XP_005266819                                                           16    7355
XP_006722604                                                           16    7355
XP_006715402                                                           16    7355
NP_006149                                                              15    9605
NP_055912                                                              15    9605
NP_055592                                                              15    9605
NP_847884                                                              15    9605
NP_006176                                                              15    9605
NP_060688                                                              15    9605
NP_001273490                                                           15    9605
XP_006719437                                                           15    9605
XP_006719436                                                           15    9605
XP_005253627                                                           15    9605
XP_006719435                                                           15    9605
XP_006718633                                                           15    9605
XP_006718632                                                           15    9605
XP_006718631                                                           15    9605
XP_006718630                                                           15    9605
XP_006718629                                                           15    9605
XP_006718628                                                           15    9605
XP_006718627                                                           15    9605
XP_006718626                                                           15    9605
XP_006718625                                                           15    9605
XP_006713122                                                           15    9605
XP_006713121                                                           15    9605
XP_006713120                                                           15    9605
XP_006713119                                                           15    9605
XP_006713118                                                           15    9605
XP_006713117                                                           15    9605
XP_006713115                                                           15    9605
XP_006713114                                                           15    9605
XP_006713111                                                           15    9605
XP_006713108                                                           15    9605
XP_006713107                                                           15    9605
XP_006713106                                                           15    9605
XP_006713104                                                           15    9605
XP_006713103                                                           15    9605
XP_006713101                                                           15    9605
XP_006713100                                                           15    9605
XP_006713099                                                           15    9605
XP_005246148                                                           15    9605
XP_005246145                                                           15    9605
XP_006712675                                                           15    9605
XP_005273417                                                           15    9605
>NP_064450
          Length = 1722

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLRTK AEL
Sbjct: 685 DLRTKIAEL 693
>XP_005273257
          Length = 1726

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLRTK AEL
Sbjct: 689 DLRTKIAEL 697
>XP_006723285
          Length = 620

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DLRTKKAEL 9
          DLRTK+ EL
Sbjct: 56 DLRTKEKEL 64
>XP_005259006
          Length = 718

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLRTK+ EL
Sbjct: 390 DLRTKEKEL 398
>XP_005259005
          Length = 719

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLRTK+ EL
Sbjct: 390 DLRTKEKEL 398
>NP_002437
          Length = 954

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLRTK+ EL
Sbjct: 390 DLRTKEKEL 398
>NP_689805
          Length = 975

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 837 DLRTRKSKL 845
>NP_055795
          Length = 1186

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL++K+AEL
Sbjct: 237 DLKSKRAEL 245
>XP_006720129
          Length = 587

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 449 DLRTRKSKL 457
>XP_006720128
          Length = 934

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 837 DLRTRKSKL 845
>XP_006720127
          Length = 970

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 832 DLRTRKSKL 840
>XP_006720126
          Length = 975

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 837 DLRTRKSKL 845
>XP_005267433
          Length = 975

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 837 DLRTRKSKL 845
>XP_005267434
          Length = 975

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DLRT+K++L
Sbjct: 837 DLRTRKSKL 845
>XP_005247964
          Length = 1162

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL++K+AEL
Sbjct: 237 DLKSKRAEL 245
>XP_006713889
          Length = 1186

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL++K+AEL
Sbjct: 237 DLKSKRAEL 245
>XP_006713888
          Length = 1186

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL++K+AEL
Sbjct: 237 DLKSKRAEL 245
>NP_001010859
          Length = 251

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DLRTKKAEL 9
          DL+ KKA+L
Sbjct: 52 DLKAKKAQL 60
>XP_005261426
          Length = 265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DLRTKKAEL 9
          DL+ KKA+L
Sbjct: 66 DLKAKKAQL 74
>NP_115811
          Length = 1036

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           +LRTK+ EL
Sbjct: 431 ELRTKEKEL 439
>NP_059990
          Length = 860

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           DLRTKK
Sbjct: 196 DLRTKK 201
>XP_005266493
          Length = 597

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           DLRTKK
Sbjct: 196 DLRTKK 201
>XP_005266492
          Length = 623

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           DLRTKK
Sbjct: 196 DLRTKK 201
>NP_061160
          Length = 1097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DLR K+AE+
Sbjct: 464 DLRGKEAEM 472
>NP_112506
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1 DLRTKKAE 8
         D +TKKAE
Sbjct: 2 DEKTKKAE 9
>NP_640337
          Length = 1115

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           DL++KKA+
Sbjct: 224 DLKSKKAD 231
>NP_001121187
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           DL++KKA+
Sbjct: 224 DLKSKKAD 231
>NP_031371
          Length = 1845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLRTKKAEL 9
            +LR K+AEL
Sbjct: 1151 ELRDKQAEL 1159
>XP_005266819
          Length = 1790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLRTKKAEL 9
            +LR K+AEL
Sbjct: 1096 ELRDKQAEL 1104
>XP_006722604
          Length = 1847

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DLRTKKAEL 9
            +LR K+AEL
Sbjct: 1153 ELRDKQAEL 1161
>XP_006715402
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           DL++KKA+
Sbjct: 224 DLKSKKAD 231
>NP_006149
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           +LRT K+E+
Sbjct: 357 ELRTTKSEM 365
>NP_055912
          Length = 1515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 823 DIRTKK 828
>NP_055592
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLRTKKAE 8
           + RTKKA+
Sbjct: 442 EFRTKKAQ 449
>NP_847884
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DL+TK+ E+
Sbjct: 232 DLQTKEQEM 240
>NP_006176
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>NP_060688
          Length = 1247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           +L+TK+AE
Sbjct: 524 ELQTKRAE 531
>NP_001273490
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006719437
          Length = 252

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DLRTKKAEL 9
          DL+TK+ E+
Sbjct: 81 DLQTKEQEM 89
>XP_006719436
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DLRTKKAEL 9
          DL+TK+ E+
Sbjct: 81 DLQTKEQEM 89
>XP_005253627
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DL+TK+ E+
Sbjct: 232 DLQTKEQEM 240
>XP_006719435
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRTKKAEL 9
           DL+TK+ E+
Sbjct: 232 DLQTKEQEM 240
>XP_006718633
          Length = 2101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718632
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718631
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718630
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718629
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718628
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718627
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718626
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006718625
          Length = 2115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DLRTKKAEL 9
           DL+T+K+++
Sbjct: 301 DLKTEKSQM 309
>XP_006713122
          Length = 1062

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 853 DIRTKK 858
>XP_006713121
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 595 DIRTKK 600
>XP_006713120
          Length = 1287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 595 DIRTKK 600
>XP_006713119
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 616 DIRTKK 621
>XP_006713118
          Length = 1328

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 619 DIRTKK 624
>XP_006713117
          Length = 1334

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 625 DIRTKK 630
>XP_006713115
          Length = 1514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 822 DIRTKK 827
>XP_006713114
          Length = 1523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 832 DIRTKK 837
>XP_006713111
          Length = 1532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 823 DIRTKK 828
>XP_006713108
          Length = 1541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 832 DIRTKK 837
>XP_006713107
          Length = 1544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 853 DIRTKK 858
>XP_006713106
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 853 DIRTKK 858
>XP_006713104
          Length = 1552

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 843 DIRTKK 848
>XP_006713103
          Length = 1553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 844 DIRTKK 849
>XP_006713101
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 853 DIRTKK 858
>XP_006713100
          Length = 1561

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 852 DIRTKK 857
>XP_006713099
          Length = 1562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DLRTKK 6
           D+RTKK
Sbjct: 853 DIRTKK 858
>XP_005246148
          Length = 1108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           +L+TK+AE
Sbjct: 385 ELQTKRAE 392
>XP_005246145
          Length = 1236

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           +L+TK+AE
Sbjct: 513 ELQTKRAE 520
>XP_006712675
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLRTKKAE 8
           +L+TK+AE
Sbjct: 525 ELQTKRAE 532
>XP_005273417
          Length = 1487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLRTKKAE 8
           + RTKKA+
Sbjct: 442 EFRTKKAQ 449
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.127    0.311 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 389,804
Number of extensions: 702
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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