Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     509
XP_006718908                                                           20     509
XP_005271621                                                           20     509
XP_006718907                                                           20     509
XP_006718906                                                           20     509
XP_005271619                                                           20     509
XP_005271618                                                           20     509
NP_057434                                                              18    1935
NP_891989                                                              18    1935
NP_065972                                                              18    1935
NP_891991                                                              18    1935
XP_006720224                                                           18    1935
XP_005267794                                                           18    1935
XP_005267793                                                           18    1935
XP_005267792                                                           18    1935
XP_006720223                                                           18    1935
NP_683515                                                              16    5631
NP_004159                                                              15    9605
NP_001363                                                              15    9605
XP_006721528                                                           15    9605
XP_005273841                                                           15    9605
XP_005273840                                                           15    9605
XP_005273839                                                           15    9605
XP_006718500                                                           15    9605
XP_005248386                                                           15    9605
NP_612480                                                              15    9605
>NP_000042
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1573 DLRITQQK 1580
>XP_006718908
          Length = 1708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   DLRITQQK 8
           DLRITQQK
Sbjct: 225 DLRITQQK 232
>XP_005271621
          Length = 2708

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1225 DLRITQQK 1232
>XP_006718907
          Length = 3050

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1567 DLRITQQK 1574
>XP_006718906
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1573 DLRITQQK 1580
>XP_005271619
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1573 DLRITQQK 1580
>XP_005271618
          Length = 3056

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLRITQQK
Sbjct: 1573 DLRITQQK 1580
>NP_057434
          Length = 1377

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1075 DLRVTQQE 1082
>NP_891989
          Length = 2046

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1788 DLRVTQQE 1795
>NP_065972
          Length = 2133

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1788 DLRVTQQE 1795
>NP_891991
          Length = 2090

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1788 DLRVTQQE 1795
>XP_006720224
          Length = 1276

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1075 DLRVTQQE 1082
>XP_005267794
          Length = 1379

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1034 DLRVTQQE 1041
>XP_005267793
          Length = 1390

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1045 DLRVTQQE 1052
>XP_005267792
          Length = 1420

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1075 DLRVTQQE 1082
>XP_006720223
          Length = 1989

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DLRITQQK 8
            DLR+TQQ+
Sbjct: 1788 DLRVTQQE 1795
>NP_683515
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLRITQQKS 9
           D+R+TQ  S
Sbjct: 875 DIRVTQNSS 883
>NP_004159
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRITQQKS 9
           +LR++ QKS
Sbjct: 510 ELRLSMQKS 518
>NP_001363
          Length = 4486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DLRITQ 6
            DLR+TQ
Sbjct: 3483 DLRVTQ 3488
>XP_006721528
          Length = 3869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DLRITQ 6
            DLR+TQ
Sbjct: 3483 DLRVTQ 3488
>XP_005273841
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRITQQK 8
          LR+TQQ+
Sbjct: 41 LRVTQQE 47
>XP_005273840
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRITQQK 8
          LR+TQQ+
Sbjct: 41 LRVTQQE 47
>XP_005273839
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRITQQK 8
          LR+TQQ+
Sbjct: 41 LRVTQQE 47
>XP_006718500
          Length = 374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRITQQK 8
          LR+TQQ+
Sbjct: 41 LRVTQQE 47
>XP_005248386
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DLRITQQKS 9
           +LR++ QKS
Sbjct: 510 ELRLSMQKS 518
>NP_612480
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LRITQQK 8
          LR+TQQ+
Sbjct: 41 LRVTQQE 47
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.124    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 423,529
Number of extensions: 817
Number of successful extensions: 26
Number of sequences better than 10000.0: 26
Number of HSP's gapped: 26
Number of HSP's successfully gapped: 26
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package