Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     869
XP_005266703                                                           19     869
NP_004035                                                              17    4312
XP_005261543                                                           17    4312
XP_005261542                                                           17    4312
XP_005265088                                                           17    4312
XP_006712608                                                           17    4312
NP_777592                                                              17    4312
NP_056281                                                              17    4312
NP_001244025                                                           16    5631
NP_006183                                                              16    5631
NP_115609                                                              16    7355
NP_002510                                                              16    7355
XP_005268184                                                           16    7355
XP_005268183                                                           16    7355
XP_006716233                                                           16    7355
NP_443085                                                              16    7355
NP_060119                                                              15    9605
NP_951058                                                              15    9605
NP_000892                                                              15    9605
NP_001159576                                                           15    9605
NP_036446                                                              15    9605
NP_006651                                                              15    9605
NP_113584                                                              15    9605
NP_620158                                                              15    9605
NP_001165108                                                           15    9605
NP_076919                                                              15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_005251984                                                           15    9605
XP_006714285                                                           15    9605
XP_005263071                                                           15    9605
XP_006712360                                                           15    9605
XP_006712359                                                           15    9605
XP_005246376                                                           15    9605
NP_065954                                                              15    9605
>NP_443179
          Length = 2170

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DLKYEQSNS 9
           DLKYEQS S
Sbjct: 736 DLKYEQSIS 744
>XP_005266703
          Length = 1501

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  DLKYEQSNS 9
          DLKYEQS S
Sbjct: 67 DLKYEQSIS 75
>NP_004035
          Length = 592

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKYEQSNS 9
           +KY QSNS
Sbjct: 425 VKYTQSNS 432
>XP_005261543
          Length = 231

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           DLKYE S+
Sbjct: 199 DLKYETSS 206
>XP_005261542
          Length = 264

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           DLKYE S+
Sbjct: 232 DLKYETSS 239
>XP_005265088
          Length = 1694

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DLKYEQS 7
           D+KYEQ+
Sbjct: 177 DIKYEQA 183
>XP_006712608
          Length = 533

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LKYEQSNS 9
           +KY QSNS
Sbjct: 366 VKYTQSNS 373
>NP_777592
          Length = 507

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           DLKYE S+
Sbjct: 475 DLKYETSS 482
>NP_056281
          Length = 1636

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DLKYEQS 7
           D+KYEQ+
Sbjct: 109 DIKYEQA 115
>NP_001244025
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLKYEQSNS 9
           D+KY QS S
Sbjct: 348 DIKYTQSAS 356
>NP_006183
          Length = 534

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLKYEQSNS 9
           D+KY QS S
Sbjct: 348 DIKYTQSAS 356
>NP_115609
          Length = 594

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KYEQSN 8
           KYE+SN
Sbjct: 501 KYEESN 506
>NP_002510
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DLKYEQSNS 9
            DLK EQ+ S
Sbjct: 1229 DLKQEQTKS 1237
>XP_005268184
          Length = 495

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KYEQSN 8
           KYE+SN
Sbjct: 402 KYEESN 407
>XP_005268183
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   KYEQSN 8
           KYE+SN
Sbjct: 443 KYEESN 448
>XP_006716233
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DLKYEQSN 8
           DL+YE  N
Sbjct: 362 DLRYEAQN 369
>NP_443085
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DLKYEQSN 8
           DL+YE  N
Sbjct: 362 DLRYEAQN 369
>NP_060119
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           +LKY++ N
Sbjct: 661 ELKYDEKN 668
>NP_951058
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           +LKY++ N
Sbjct: 661 ELKYDEKN 668
>NP_000892
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   DLKYEQSN 8
           D  YEQ N
Sbjct: 116 DYSYEQQN 123
>NP_001159576
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   DLKYEQSN 8
           D  YEQ N
Sbjct: 116 DYSYEQQN 123
>NP_036446
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DLKYEQSNS 9
           D  YE SNS
Sbjct: 204 DAPYEWSNS 212
>NP_006651
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLKYEQSN 8
           D+K E+SN
Sbjct: 281 DIKLEKSN 288
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>NP_620158
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLKYEQSNS 9
           DLKY Q ++
Sbjct: 136 DLKYRQHHT 144
>NP_001165108
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DLKYEQSNS 9
          DLKY Q ++
Sbjct: 50 DLKYRQHHT 58
>NP_076919
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  YEQSNS 9
          Y+QSNS
Sbjct: 58 YQQSNS 63
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1599 KYLQSNS 1605
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    KYEQSNS 9
            KY QSNS
Sbjct: 1608 KYLQSNS 1614
>XP_005251984
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DLKYEQSNS 9
           DLKY Q  S
Sbjct: 260 DLKYTQLKS 268
>XP_006714285
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   DLKYEQSN 8
           D  YEQ N
Sbjct: 116 DYSYEQQN 123
>XP_005263071
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1   DLKYEQSN 8
           D  YEQ N
Sbjct: 116 DYSYEQQN 123
>XP_006712360
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DLKYEQSNS 9
          DLKY Q ++
Sbjct: 50 DLKYRQHHT 58
>XP_006712359
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLKYEQSNS 9
           DLKY Q ++
Sbjct: 122 DLKYRQHHT 130
>XP_005246376
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLKYEQSNS 9
           DLKY Q ++
Sbjct: 157 DLKYRQHHT 165
>NP_065954
          Length = 922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LKYEQSN 8
           LKY QSN
Sbjct: 200 LKYIQSN 206
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.112    0.274 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 556,899
Number of extensions: 832
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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