Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              20     509
NP_057636                                                              17    2528
NP_001269700                                                           17    2528
XP_006712630                                                           17    2528
NP_001277113                                                           17    4312
NP_001277115                                                           17    4312
NP_056146                                                              17    4312
NP_004651                                                              16    5631
NP_001116137                                                           16    5631
NP_612372                                                              16    5631
XP_006724941                                                           16    5631
XP_005262621                                                           16    5631
XP_006724940                                                           16    5631
XP_005257840                                                           16    5631
XP_005257839                                                           16    5631
XP_006722230                                                           16    5631
XP_006722229                                                           16    5631
XP_005257838                                                           16    5631
XP_005257837                                                           16    5631
XP_005257836                                                           16    5631
XP_005257835                                                           16    5631
XP_005257834                                                           16    5631
NP_003349                                                              16    7355
NP_001265432                                                           16    7355
NP_689926                                                              16    7355
NP_003162                                                              16    7355
NP_001265433                                                           16    7355
NP_597707                                                              16    7355
NP_588611                                                              16    7355
NP_001026902                                                           16    7355
NP_001229858                                                           16    7355
XP_005275696                                                           16    7355
XP_005275695                                                           16    7355
XP_005275694                                                           16    7355
XP_005255178                                                           16    7355
XP_005255176                                                           16    7355
XP_005265765                                                           16    7355
XP_005265764                                                           16    7355
XP_005265763                                                           16    7355
NP_899662                                                              15    9605
NP_002886                                                              15    9605
NP_004752                                                              15    9605
NP_001230667                                                           15    9605
XP_005275492                                                           15    9605
XP_005275491                                                           15    9605
XP_005275332                                                           15    9605
XP_005275331                                                           15    9605
XP_005275330                                                           15    9605
XP_005275063                                                           15    9605
XP_005275062                                                           15    9605
XP_005275061                                                           15    9605
XP_005272907                                                           15    9605
XP_005272906                                                           15    9605
XP_005272905                                                           15    9605
XP_006723905                                                           15    9605
XP_005249315                                                           15    9605
XP_005249314                                                           15    9605
XP_005249313                                                           15    9605
NP_061741                                                              15    9605
NP_114443                                                              15    9605
>NP_000312
          Length = 928

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   DLDARLFL 8
           DLDARLFL
Sbjct: 330 DLDARLFL 337
>NP_057636
          Length = 941

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DLDARLFL 8
           +LDAR+FL
Sbjct: 189 ELDARIFL 196
>NP_001269700
          Length = 1030

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DLDARLFL 8
           +LDAR+FL
Sbjct: 278 ELDARIFL 285
>XP_006712630
          Length = 941

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DLDARLFL 8
           +LDAR+FL
Sbjct: 189 ELDARIFL 196
>NP_001277113
          Length = 689

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLDARLFLI 9
           D+ AR+FLI
Sbjct: 635 DIRARIFLI 643
>NP_001277115
          Length = 571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLDARLFLI 9
           D+ AR+FLI
Sbjct: 517 DIRARIFLI 525
>NP_056146
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLDARLFLI 9
           D+ AR+FLI
Sbjct: 655 DIRARIFLI 663
>NP_004651
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD R FL+
Sbjct: 422 DLDKRSFLL 430
>NP_001116137
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD R FL+
Sbjct: 422 DLDKRSFLL 430
>NP_612372
          Length = 821

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 304 DLDDGLFLI 312
>XP_006724941
          Length = 637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD R FL+
Sbjct: 422 DLDKRSFLL 430
>XP_005262621
          Length = 657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD R FL+
Sbjct: 419 DLDKRSFLL 427
>XP_006724940
          Length = 660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD R FL+
Sbjct: 422 DLDKRSFLL 430
>XP_005257840
          Length = 488

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 352 DLDDGLFLI 360
>XP_005257839
          Length = 572

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 352 DLDDGLFLI 360
>XP_006722230
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 92  DLDDGLFLI 100
>XP_006722229
          Length = 610

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 92  DLDDGLFLI 100
>XP_005257838
          Length = 657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 140 DLDDGLFLI 148
>XP_005257837
          Length = 658

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 140 DLDDGLFLI 148
>XP_005257836
          Length = 822

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 304 DLDDGLFLI 312
>XP_005257835
          Length = 869

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 352 DLDDGLFLI 360
>XP_005257834
          Length = 870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  LFLI
Sbjct: 352 DLDDGLFLI 360
>NP_003349
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DLDARLFL 8
           ++DARLF+
Sbjct: 107 NVDARLFI 114
>NP_001265432
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DARLFLI 9
           DAR+F+I
Sbjct: 384 DARIFII 390
>NP_689926
          Length = 705

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DARLFLI 9
           DAR+F+I
Sbjct: 384 DARIFII 390
>NP_003162
          Length = 786

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LDARLF 7
           LDARLF
Sbjct: 115 LDARLF 120
>NP_001265433
          Length = 613

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   DARLFLI 9
           DAR+F+I
Sbjct: 292 DARIFII 298
>NP_597707
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLDARLFL 8
           D+D R+FL
Sbjct: 450 DVDLRIFL 457
>NP_588611
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 336 DARFFLI 342
>NP_001026902
          Length = 727

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 354 DARFFLI 360
>NP_001229858
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLDARLFL 8
           D+D R+FL
Sbjct: 343 DVDLRIFL 350
>XP_005275696
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 336 DARFFLI 342
>XP_005275695
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 339 DARFFLI 345
>XP_005275694
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 354 DARFFLI 360
>XP_005255178
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLDARLFL 8
           D+D R+FL
Sbjct: 244 DVDLRIFL 251
>XP_005255176
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DLDARLFL 8
           D+D R+FL
Sbjct: 321 DVDLRIFL 328
>XP_005265765
          Length = 717

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 336 DARFFLI 342
>XP_005265764
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 339 DARFFLI 345
>XP_005265763
          Length = 735

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   DARLFLI 9
           DAR FLI
Sbjct: 354 DARFFLI 360
>NP_899662
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DLDARLFL 8
           D D R+FL
Sbjct: 315 DFDERIFL 322
>NP_002886
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DLDARLFL 8
           D D R+FL
Sbjct: 315 DFDERIFL 322
>NP_004752
          Length = 777

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>NP_001230667
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005275492
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005275491
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005275332
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005275331
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005275330
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005275063
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005275062
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005275061
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005272907
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005272906
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005272905
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_006723905
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DLDARLFL 8
           D D R+FL
Sbjct: 143 DFDERIFL 150
>XP_005249315
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 172 LDAELFL 178
>XP_005249314
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>XP_005249313
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   LDARLFL 8
           LDA LFL
Sbjct: 254 LDAELFL 260
>NP_061741
          Length = 931

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  L+L+
Sbjct: 686 DLDLTLYLV 694
>NP_114443
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLDARLFLI 9
           DLD  L+L+
Sbjct: 686 DLDLTLYLV 694
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.166    0.465 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 410,031
Number of extensions: 742
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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