Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001035810                                                           18    1935
NP_000393                                                              18    1935
XP_005274715                                                           18    1935
XP_005274714                                                           18    1935
NP_001182682                                                           17    3301
NP_001182681                                                           17    3301
XP_005263589                                                           17    3301
NP_000069                                                              16    5631
NP_001273014                                                           16    5631
NP_001191351                                                           16    5631
NP_001191347                                                           16    5631
NP_001116836                                                           16    5631
NP_001009899                                                           16    7355
NP_002461                                                              16    7355
NP_001161328                                                           16    7355
NP_060653                                                              16    7355
NP_037493                                                              16    7355
NP_001136087                                                           16    7355
NP_009120                                                              16    7355
NP_003416                                                              16    7355
NP_653081                                                              16    7355
NP_037530                                                              16    7355
NP_055650                                                              16    7355
NP_001265578                                                           16    7355
NP_001136086                                                           16    7355
NP_001193934                                                           16    7355
NP_079225                                                              16    7355
NP_001803                                                              16    7355
NP_005683                                                              16    7355
NP_861421                                                              16    7355
XP_005260682                                                           16    7355
XP_005259279                                                           16    7355
XP_005259278                                                           16    7355
XP_006723428                                                           16    7355
XP_006721591                                                           16    7355
XP_005253633                                                           16    7355
XP_005253632                                                           16    7355
XP_006719537                                                           16    7355
XP_006719536                                                           16    7355
XP_005253630                                                           16    7355
XP_005253629                                                           16    7355
XP_006715887                                                           16    7355
XP_005249988                                                           16    7355
XP_006714375                                                           16    7355
XP_006714128                                                           16    7355
XP_006714127                                                           16    7355
XP_005247266                                                           16    7355
XP_005247265                                                           16    7355
XP_006712034                                                           16    7355
XP_005264284                                                           16    7355
XP_005264283                                                           16    7355
XP_005264282                                                           16    7355
NP_001136088                                                           16    7355
NP_056067                                                              16    7355
NP_037494                                                              16    7355
NP_000882                                                              15    9605
NP_003842                                                              15    9605
NP_660153                                                              15    9605
XP_006717677                                                           15    9605
XP_006717676                                                           15    9605
XP_006717675                                                           15    9605
XP_005269545                                                           15    9605
XP_006717671                                                           15    9605
XP_006717670                                                           15    9605
XP_006717669                                                           15    9605
XP_006717668                                                           15    9605
XP_006717667                                                           15    9605
XP_005275805                                                           15    9605
YP_003024035                                                           15    9605
>NP_001035810
          Length = 515

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLAKKK++
Sbjct: 42 DLAKKKIY 49
>NP_000393
          Length = 545

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLAKKK++
Sbjct: 72 DLAKKKIY 79
>XP_005274715
          Length = 516

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLAKKK++
Sbjct: 42 DLAKKKIY 49
>XP_005274714
          Length = 546

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLAKKK++
Sbjct: 72 DLAKKKIY 79
>NP_001182682
          Length = 239

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLFL
Sbjct: 186 DSLKKKLFL 194
>NP_001182681
          Length = 238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLFL
Sbjct: 185 DSLKKKLFL 193
>XP_005263589
          Length = 238

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLFL
Sbjct: 185 DSLKKKLFL 193
>NP_000069
          Length = 493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AKKKLFL 9
           +KKKLFL
Sbjct: 393 SKKKLFL 399
>NP_001273014
          Length = 433

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AKKKLFL 9
           +KKKLFL
Sbjct: 333 SKKKLFL 339
>NP_001191351
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LAKKKLF 8
           LAKKKL+
Sbjct: 415 LAKKKLY 421
>NP_001191347
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LAKKKLF 8
           LAKKKL+
Sbjct: 452 LAKKKLY 458
>NP_001116836
          Length = 366

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DLAKKKLFL 9
           DL+K +LFL
Sbjct: 337 DLSKPQLFL 345
>NP_001009899
          Length = 2245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    DLAKKK 6
            DLAKKK
Sbjct: 1010 DLAKKK 1015
>NP_002461
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 204 DLAKKK 209
>NP_001161328
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1227 KKKLFL 1232
>NP_060653
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1226 KKKLFL 1231
>NP_037493
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>NP_001136087
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_009120
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 DLAKKK 6
         DLAKKK
Sbjct: 4 DLAKKK 9
>NP_003416
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>NP_653081
          Length = 480

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLF+
Sbjct: 289 DKNKKKLFM 297
>NP_037530
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>NP_055650
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLF+
Sbjct: 277 DKNKKKLFM 285
>NP_001265578
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D  KKKLF+
Sbjct: 197 DKNKKKLFM 205
>NP_001136086
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_001193934
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>NP_079225
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAKKKLFL 9
            LAKK LF+
Sbjct: 1027 LAKKSLFV 1034
>NP_001803
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 624 DLAKKK 629
>NP_005683
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 DLAKKK 6
         DLAKKK
Sbjct: 4 DLAKKK 9
>NP_861421
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>XP_005260682
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          D  KKKLF+
Sbjct: 76 DKNKKKLFM 84
>XP_005259279
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>XP_005259278
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>XP_006723428
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>XP_006721591
          Length = 1940

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 204 DLAKKK 209
>XP_005253633
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1226 KKKLFL 1231
>XP_005253632
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1226 KKKLFL 1231
>XP_006719537
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1227 KKKLFL 1232
>XP_006719536
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1227 KKKLFL 1232
>XP_005253630
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1227 KKKLFL 1232
>XP_005253629
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    KKKLFL 9
            KKKLFL
Sbjct: 1227 KKKLFL 1232
>XP_006715887
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 DLAKKK 6
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_005249988
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 DLAKKK 6
         DLAKKK
Sbjct: 4 DLAKKK 9
>XP_006714375
          Length = 1208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    LAKKKLFL 9
            LAKK LF+
Sbjct: 1043 LAKKSLFV 1050
>XP_006714128
          Length = 730

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 411 DLAKKK 416
>XP_006714127
          Length = 935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 624 DLAKKK 629
>XP_005247266
          Length = 2189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 954 DLAKKK 959
>XP_005247265
          Length = 2211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 976 DLAKKK 981
>XP_006712034
          Length = 1195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264284
          Length = 1196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 738 DLAKKK 743
>XP_005264283
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 773 DLAKKK 778
>XP_005264282
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_001136088
          Length = 1160

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 738 DLAKKK 743
>NP_056067
          Length = 1231

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DLAKKK 6
           DLAKKK
Sbjct: 773 DLAKKK 778
>NP_037494
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DLAKKKLF 8
          DLA++KL+
Sbjct: 26 DLAQRKLY 33
>NP_000882
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           DLA+KK  L
Sbjct: 360 DLAEKKYIL 368
>NP_003842
          Length = 220

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D+AK  LF+
Sbjct: 165 DIAKHSLFI 173
>NP_660153
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717677
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717676
          Length = 793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717675
          Length = 877

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_005269545
          Length = 1051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717671
          Length = 1091

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717670
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717669
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717668
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_006717667
          Length = 1121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  DLAKKKLFL 9
          DLA K +FL
Sbjct: 76 DLAHKPVFL 84
>XP_005275805
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DLAKKKLFL 9
           D AKK L+L
Sbjct: 221 DNAKKSLYL 229
>YP_003024035
          Length = 459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LAKKKLFL 9
          L++KKL+L
Sbjct: 89 LSRKKLYL 96
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.147    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 495,939
Number of extensions: 656
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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