Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_001258698                                                           17    3301
NP_003655                                                              17    3301
XP_005248675                                                           17    3301
NP_000752                                                              17    4312
NP_001248390                                                           16    7355
NP_001129495                                                           16    7355
NP_006154                                                              16    7355
NP_001018081                                                           16    7355
NP_006775                                                              16    7355
NP_060729                                                              16    7355
NP_036250                                                              16    7355
XP_005268964                                                           16    7355
XP_005268963                                                           16    7355
XP_005253074                                                           16    7355
XP_006718326                                                           16    7355
XP_005253073                                                           16    7355
NP_001165907                                                           15    9605
NP_002628                                                              15    9605
NP_001116142                                                           15    9605
NP_940861                                                              15    9605
NP_001243333                                                           15    9605
NP_003195                                                              15    9605
NP_602296                                                              15    9605
NP_065890                                                              15    9605
NP_065910                                                              15    9605
NP_056380                                                              15    9605
NP_055796                                                              15    9605
NP_065768                                                              15    9605
NP_001640                                                              15    9605
XP_006724724                                                           15    9605
XP_006724654                                                           15    9605
XP_006724653                                                           15    9605
XP_005274557                                                           15    9605
XP_006724050                                                           15    9605
XP_005257472                                                           15    9605
XP_005257470                                                           15    9605
XP_005257469                                                           15    9605
XP_005257468                                                           15    9605
XP_005257467                                                           15    9605
XP_005253784                                                           15    9605
XP_005253782                                                           15    9605
XP_006719060                                                           15    9605
XP_006719059                                                           15    9605
XP_006719058                                                           15    9605
XP_005253778                                                           15    9605
XP_005253777                                                           15    9605
XP_005263222                                                           15    9605
XP_005263221                                                           15    9605
XP_005263220                                                           15    9605
XP_006714345                                                           15    9605
XP_005263219                                                           15    9605
XP_005265403                                                           15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DKIVNLANI 9
            DKIV+LANI
Sbjct: 2453 DKIVDLANI 2461
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DKIVNLANI 9
            DKIV+LANI
Sbjct: 2248 DKIVDLANI 2256
>NP_001258698
          Length = 1045

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KIVNLANI 9
           K+VN+AN+
Sbjct: 976 KVVNVANV 983
>NP_003655
          Length = 1094

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIVNLANI 9
            K+VN+AN+
Sbjct: 1025 KVVNVANV 1032
>XP_005248675
          Length = 1053

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    KIVNLANI 9
            K+VN+AN+
Sbjct: 1025 KVVNVANV 1032
>NP_000752
          Length = 516

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DKIVNLAN 8
           +KIVNL N
Sbjct: 305 EKIVNLVN 312
>NP_001248390
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKIVNL
Sbjct: 240 DKIVNL 245
>NP_001129495
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKIVNL
Sbjct: 240 DKIVNL 245
>NP_006154
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKIVNL
Sbjct: 240 DKIVNL 245
>NP_001018081
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DKIVNLANI 9
           DK V +AN+
Sbjct: 654 DKFVQMANL 662
>NP_006775
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DKIVNLA 7
           D++VNLA
Sbjct: 280 DRVVNLA 286
>NP_060729
          Length = 1141

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 265 LVNLANV 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 658 LVNLANL 664
>NP_036250
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KIVNLANI 9
           K+VN ANI
Sbjct: 246 KLVNSANI 253
>XP_005268964
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKIVNL
Sbjct: 240 DKIVNL 245
>XP_005268963
          Length = 373

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKIVNL
Sbjct: 240 DKIVNL 245
>XP_005253074
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 265 LVNLANV 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 658 LVNLANL 664
>XP_006718326
          Length = 968

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IVNLANI 9
          +VNLAN+
Sbjct: 35 LVNLANV 41

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 428 LVNLANL 434
>XP_005253073
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 265 LVNLANV 271

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IVNLANI 9
           +VNLAN+
Sbjct: 658 LVNLANL 664
>NP_001165907
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DKIVNLAN 8
            +KIV++AN
Sbjct: 1080 EKIVHIAN 1087
>NP_002628
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DKIVNLAN 8
            +KIV++AN
Sbjct: 1152 EKIVHIAN 1159
>NP_001116142
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DKIVNLAN 8
            +KIV++AN
Sbjct: 1139 EKIVHIAN 1146
>NP_940861
          Length = 871

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DKIVNLA 7
           DK++NLA
Sbjct: 159 DKLLNLA 165
>NP_001243333
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DKIVNLA 7
           DK++NLA
Sbjct: 159 DKLLNLA 165
>NP_003195
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 628 DKIINL 633
>NP_602296
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>NP_065890
          Length = 677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DKIVNLAN 8
           +KI+NL N
Sbjct: 602 EKIINLDN 609
>NP_065910
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1842 DKVVNL 1847
>NP_056380
          Length = 1812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DKIVNLAN 8
           +K+VNLA+
Sbjct: 789 EKLVNLAD 796
>NP_055796
          Length = 1946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DKIVNLAN 8
            DK+  LAN
Sbjct: 1276 DKVTQLAN 1283
>NP_065768
          Length = 1493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1373 DKVVNL 1378
>NP_001640
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1496 DKVVNL 1501
>XP_006724724
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DKIVNLAN 8
            +KIV++AN
Sbjct: 1093 EKIVHIAN 1100
>XP_006724654
          Length = 1335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1215 DKVVNL 1220
>XP_006724653
          Length = 1377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1257 DKVVNL 1262
>XP_005274557
          Length = 1615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1495 DKVVNL 1500
>XP_006724050
          Length = 925

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DKIVNLAN 8
           +K+VNLA+
Sbjct: 789 EKLVNLAD 796
>XP_005257472
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 587 DKIINL 592
>XP_005257470
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 598 DKIINL 603
>XP_005257469
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 598 DKIINL 603
>XP_005257468
          Length = 761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 617 DKIINL 622
>XP_005257467
          Length = 772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DKIVNL 6
           DKI+NL
Sbjct: 628 DKIINL 633
>XP_005253784
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_005253782
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_006719060
          Length = 301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_006719059
          Length = 340

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_006719058
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_005253778
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_005253777
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  KIVNLAN 8
          +++NLAN
Sbjct: 70 RVINLAN 76
>XP_005263222
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1666 DKVVNL 1671
>XP_005263221
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1666 DKVVNL 1671
>XP_005263220
          Length = 1820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1666 DKVVNL 1671
>XP_006714345
          Length = 1961

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1807 DKVVNL 1812
>XP_005263219
          Length = 1996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    DKIVNL 6
            DK+VNL
Sbjct: 1842 DKVVNL 1847
>XP_005265403
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DKIVNLAN 8
           +KI+NL N
Sbjct: 602 EKIINLDN 609
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.140    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 326,019
Number of extensions: 519
Number of successful extensions: 58
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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