Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              19     869
NP_653080                                                              19     869
XP_005267292                                                           19     869
XP_005267291                                                           19     869
XP_005267290                                                           19     869
NP_001011719                                                           17    2528
NP_061720                                                              17    3301
NP_001660                                                              17    4312
XP_005274571                                                           17    4312
NP_689637                                                              16    5631
NP_110394                                                              16    5631
NP_060542                                                              16    5631
NP_001186010                                                           16    5631
NP_001186011                                                           16    5631
NP_714914                                                              16    5631
NP_958357                                                              16    5631
NP_001186009                                                           16    5631
XP_005262298                                                           16    5631
XP_006717358                                                           16    5631
XP_005252305                                                           16    5631
XP_005252303                                                           16    5631
XP_006717357                                                           16    5631
XP_005252304                                                           16    5631
XP_005252302                                                           16    5631
XP_005252301                                                           16    5631
XP_005252300                                                           16    5631
XP_005271318                                                           16    5631
XP_005271317                                                           16    5631
XP_005271314                                                           16    5631
XP_005270514                                                           16    5631
NP_061925                                                              16    7355
NP_001099034                                                           16    7355
NP_001099033                                                           16    7355
NP_065842                                                              16    7355
NP_079418                                                              16    7355
NP_004808                                                              16    7355
NP_001164101                                                           16    7355
NP_963923                                                              16    7355
NP_001077395                                                           16    7355
NP_079356                                                              16    7355
NP_777360                                                              16    7355
NP_001163886                                                           16    7355
NP_002807                                                              16    7355
XP_006726067                                                           16    7355
XP_005275480                                                           16    7355
XP_005275479                                                           16    7355
XP_006726066                                                           16    7355
XP_005275322                                                           16    7355
XP_005275194                                                           16    7355
XP_005275048                                                           16    7355
XP_005275047                                                           16    7355
XP_005275045                                                           16    7355
XP_005275044                                                           16    7355
XP_006725765                                                           16    7355
XP_005272893                                                           16    7355
XP_005272892                                                           16    7355
XP_005272890                                                           16    7355
XP_005272889                                                           16    7355
XP_006725551                                                           16    7355
XP_006721616                                                           16    7355
XP_005274361                                                           16    7355
XP_005252372                                                           16    7355
XP_006717387                                                           16    7355
XP_005252371                                                           16    7355
XP_005252370                                                           16    7355
XP_005252369                                                           16    7355
XP_005252368                                                           16    7355
XP_006715182                                                           16    7355
XP_005247407                                                           16    7355
NP_060616                                                              16    7355
NP_055190                                                              16    7355
NP_001163885                                                           16    7355
NP_001163887                                                           16    7355
NP_065805                                                              15    9605
XP_005247728                                                           15    9605
XP_006713777                                                           15    9605
>NP_005091
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DISKDRSEA 9
            DISKD SEA
Sbjct: 1629 DISKDMSEA 1637
>NP_653080
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DISKDRSEA 9
            DISKD SEA
Sbjct: 1531 DISKDMSEA 1539
>XP_005267292
          Length = 1677

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DISKDRSEA 9
            DISKD SEA
Sbjct: 1524 DISKDMSEA 1532
>XP_005267291
          Length = 1684

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DISKDRSEA 9
            DISKD SEA
Sbjct: 1531 DISKDMSEA 1539
>XP_005267290
          Length = 1782

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    DISKDRSEA 9
            DISKD SEA
Sbjct: 1629 DISKDMSEA 1637
>NP_001011719
          Length = 562

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D SEA
Sbjct: 484 DISRDPSEA 492
>NP_061720
          Length = 4024

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1    DISKDRSE 8
            DI+KD+SE
Sbjct: 3715 DITKDQSE 3722
>NP_001660
          Length = 593

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           D+S+D SEA
Sbjct: 518 DLSRDPSEA 526
>XP_005274571
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           D+S+D SEA
Sbjct: 473 DLSRDPSEA 481
>NP_689637
          Length = 1135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    DISKDRSE 8
            D+SK+R+E
Sbjct: 1108 DLSKERAE 1115
>NP_110394
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>NP_060542
          Length = 2144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    ISKDRSEA 9
            ISK+R+EA
Sbjct: 2011 ISKERAEA 2018
>NP_001186010
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DISKDR 6
           DISKDR
Sbjct: 616 DISKDR 621
>NP_001186011
          Length = 519

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DISKDR 6
           DISKDR
Sbjct: 493 DISKDR 498
>NP_714914
          Length = 661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DISKDR 6
           DISKDR
Sbjct: 635 DISKDR 640
>NP_958357
          Length = 1327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DISKDRSE 8
          ++SKD+SE
Sbjct: 77 ELSKDKSE 84
>NP_001186009
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DISKDR 6
           DISKDR
Sbjct: 616 DISKDR 621
>XP_005262298
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DISKDRSE 8
           D+SK+R+E
Sbjct: 831 DLSKERAE 838
>XP_006717358
          Length = 831

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252305
          Length = 1407

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252303
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_006717357
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252304
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252302
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252301
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005252300
          Length = 1439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DISKDRSEA 9
           DIS+D+S A
Sbjct: 552 DISEDQSSA 560
>XP_005271318
          Length = 1327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DISKDRSE 8
          ++SKD+SE
Sbjct: 77 ELSKDKSE 84
>XP_005271317
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DISKDRSE 8
          ++SKD+SE
Sbjct: 77 ELSKDKSE 84
>XP_005271314
          Length = 1368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  DISKDRSE 8
          ++SKD+SE
Sbjct: 77 ELSKDKSE 84
>XP_005270514
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   DISKDR 6
           DISKDR
Sbjct: 587 DISKDR 592
>NP_061925
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>NP_001099034
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DISKDRSE 8
           D+S DR E
Sbjct: 153 DVSSDRQE 160
>NP_001099033
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DISKDRSE 8
           D+S DR E
Sbjct: 117 DVSSDRQE 124
>NP_065842
          Length = 1001

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DISKDRSE 8
           D+S D+SE
Sbjct: 373 DVSDDKSE 380
>NP_079418
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DISKDRSE 8
           D+S D+SE
Sbjct: 373 DVSDDKSE 380
>NP_004808
          Length = 1190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 190 DLSRDRS 196
>NP_001164101
          Length = 993

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 190 DLSRDRS 196
>NP_963923
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 190 DLSRDRS 196
>NP_001077395
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  ISKDRSE 8
          ISKDR E
Sbjct: 15 ISKDRKE 21
>NP_079356
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  ISKDRSE 8
          ISKDR E
Sbjct: 15 ISKDRKE 21
>NP_777360
          Length = 436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DISKDRSEA 9
           D+S D SEA
Sbjct: 363 DLSVDESEA 371
>NP_001163886
          Length = 1157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 194 DLSRDRS 200
>NP_002807
          Length = 456

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DISKDRSEA 9
           D+S D SEA
Sbjct: 383 DLSVDESEA 391
>XP_006726067
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275480
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275479
          Length = 837

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DISKDRSE 8
           D+S DR E
Sbjct: 153 DVSSDRQE 160
>XP_006726066
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DISKDRSE 8
           D+S DR E
Sbjct: 134 DVSSDRQE 141
>XP_005275322
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275194
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275048
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275047
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275045
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005275044
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_006725765
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005272893
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005272892
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005272890
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_005272889
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_006725551
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  DISKDRSE 8
          D+S DR E
Sbjct: 64 DVSSDRQE 71
>XP_006721616
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 216 DLSRDRS 222
>XP_005274361
          Length = 218

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  ISKDRSE 8
          ISKDR E
Sbjct: 15 ISKDRKE 21
>XP_005252372
          Length = 1102

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 249 DLSRDRS 255
>XP_006717387
          Length = 1188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 188 DLSRDRS 194
>XP_005252371
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 194 DLSRDRS 200
>XP_005252370
          Length = 1212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 249 DLSRDRS 255
>XP_005252369
          Length = 1213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 213 DLSRDRS 219
>XP_005252368
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 249 DLSRDRS 255
>XP_006715182
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DISKDRSE 8
           D+S DR E
Sbjct: 134 DVSSDRQE 141
>XP_005247407
          Length = 317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DISKDRSE 8
          DI+KDR +
Sbjct: 51 DINKDRKD 58
>NP_060616
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 412 DLSRDRS 418
>NP_055190
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DISKDRSE 8
          DI+KDR +
Sbjct: 51 DINKDRKD 58
>NP_001163885
          Length = 1020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 167 DLSRDRS 173
>NP_001163887
          Length = 1221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DISKDRS 7
           D+S+DRS
Sbjct: 221 DLSRDRS 227
>NP_065805
          Length = 1444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DISKDRS 7
           D+S DRS
Sbjct: 412 DVSSDRS 418
>XP_005247728
          Length = 1413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DISKDRS 7
           D+S DRS
Sbjct: 381 DVSSDRS 387
>XP_006713777
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DISKDRS 7
           D+S DRS
Sbjct: 392 DVSSDRS 398
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.295    0.115    0.273 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 497,622
Number of extensions: 813
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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