Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              19     869
XP_005273257                                                           19     869
NP_001073998                                                           18    1482
XP_005249879                                                           18    1482
XP_005256244                                                           16    5631
XP_006721357                                                           16    5631
XP_006721356                                                           16    5631
NP_001153685                                                           16    5631
NP_112583                                                              16    5631
NP_000436                                                              16    7355
NP_958780                                                              16    7355
NP_958781                                                              16    7355
NP_958785                                                              16    7355
NP_958783                                                              16    7355
NP_958786                                                              16    7355
NP_958782                                                              16    7355
NP_958784                                                              16    7355
NP_775824                                                              16    7355
XP_005251041                                                           16    7355
XP_005251040                                                           16    7355
XP_006716653                                                           16    7355
XP_006716652                                                           16    7355
XP_005251039                                                           16    7355
XP_005251038                                                           16    7355
XP_005251036                                                           16    7355
XP_005251037                                                           16    7355
XP_005251035                                                           16    7355
XP_006716651                                                           16    7355
XP_005251034                                                           16    7355
XP_005251033                                                           16    7355
XP_006714199                                                           16    7355
NP_694950                                                              15    9605
NP_001121775                                                           15    9605
NP_055873                                                              15    9605
NP_892006                                                              15    9605
NP_149062                                                              15    9605
XP_006719854                                                           15    9605
XP_006719853                                                           15    9605
XP_006719829                                                           15    9605
XP_005266318                                                           15    9605
XP_006715488                                                           15    9605
XP_006715487                                                           15    9605
XP_006715486                                                           15    9605
XP_006715485                                                           15    9605
XP_006715484                                                           15    9605
XP_006715483                                                           15    9605
XP_006715482                                                           15    9605
XP_006715481                                                           15    9605
XP_006715480                                                           15    9605
XP_006715479                                                           15    9605
XP_006715478                                                           15    9605
XP_006715477                                                           15    9605
XP_006715476                                                           15    9605
XP_006715475                                                           15    9605
XP_006715474                                                           15    9605
XP_006715473                                                           15    9605
XP_006715472                                                           15    9605
XP_006715471                                                           15    9605
XP_006715470                                                           15    9605
>NP_064450
          Length = 1722

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DIQQATRLQ 9
           DIQQA RLQ
Sbjct: 198 DIQQAIRLQ 206
>XP_005273257
          Length = 1726

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DIQQATRLQ 9
           DIQQA RLQ
Sbjct: 198 DIQQAIRLQ 206
>NP_001073998
          Length = 483

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DIQQATRLQ 9
          DIQQ TRL+
Sbjct: 52 DIQQGTRLR 60
>XP_005249879
          Length = 483

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DIQQATRLQ 9
          DIQQ TRL+
Sbjct: 52 DIQQGTRLR 60
>XP_005256244
          Length = 807

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           D+Q+AT+L
Sbjct: 608 DLQEATKL 615
>XP_006721357
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           D+Q+AT+L
Sbjct: 608 DLQEATKL 615
>XP_006721356
          Length = 1017

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           D+Q+AT+L
Sbjct: 608 DLQEATKL 615
>NP_001153685
          Length = 882

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           D+Q+AT+L
Sbjct: 463 DLQEATKL 470
>NP_112583
          Length = 1007

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           D+Q+AT+L
Sbjct: 608 DLQEATKL 615
>NP_000436
          Length = 4574

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2346 VQEATRLK 2353
>NP_958780
          Length = 4533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2305 VQEATRLK 2312
>NP_958781
          Length = 4525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2297 VQEATRLK 2304
>NP_958785
          Length = 4551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2323 VQEATRLK 2330
>NP_958783
          Length = 4515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2287 VQEATRLK 2294
>NP_958786
          Length = 4547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2319 VQEATRLK 2326
>NP_958782
          Length = 4684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2456 VQEATRLK 2463
>NP_958784
          Length = 4547

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2319 VQEATRLK 2326
>NP_775824
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIQQATRLQ 9
           D+++ATR Q
Sbjct: 259 DVEKATRWQ 267
>XP_005251041
          Length = 4520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2292 VQEATRLK 2299
>XP_005251040
          Length = 4524

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2296 VQEATRLK 2303
>XP_006716653
          Length = 4529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2301 VQEATRLK 2308
>XP_006716652
          Length = 4529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2301 VQEATRLK 2308
>XP_005251039
          Length = 4530

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2302 VQEATRLK 2309
>XP_005251038
          Length = 4538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2310 VQEATRLK 2317
>XP_005251036
          Length = 4552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2324 VQEATRLK 2331
>XP_005251037
          Length = 4552

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2324 VQEATRLK 2331
>XP_005251035
          Length = 4556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2328 VQEATRLK 2335
>XP_006716651
          Length = 4579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2351 VQEATRLK 2358
>XP_005251034
          Length = 4685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2457 VQEATRLK 2464
>XP_005251033
          Length = 4689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQQATRLQ 9
            +Q+ATRL+
Sbjct: 2461 VQEATRLK 2468
>XP_006714199
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIQQATRLQ 9
           D+++ATR Q
Sbjct: 309 DVEKATRWQ 317
>NP_694950
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           DI++ATR+
Sbjct: 372 DIRKATRI 379
>NP_001121775
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           DI++ATR+
Sbjct: 372 DIRKATRI 379
>NP_055873
          Length = 1905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QATRLQ 9
            QATRLQ
Sbjct: 1867 QATRLQ 1872
>NP_892006
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7969 IQQATR 7974
>NP_149062
          Length = 8749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7898 IQQATR 7903
>XP_006719854
          Length = 1550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QATRLQ 9
            QATRLQ
Sbjct: 1512 QATRLQ 1517
>XP_006719853
          Length = 1809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    QATRLQ 9
            QATRLQ
Sbjct: 1771 QATRLQ 1776
>XP_006719829
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           DI++ATR+
Sbjct: 372 DIRKATRI 379
>XP_005266318
          Length = 430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQQATRL 8
           DI++ATR+
Sbjct: 372 DIRKATRI 379
>XP_006715488
          Length = 8721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715487
          Length = 8744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715486
          Length = 8758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715485
          Length = 8793

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7928 IQQATR 7933
>XP_006715484
          Length = 8794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7929 IQQATR 7934
>XP_006715483
          Length = 8795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7930 IQQATR 7935
>XP_006715482
          Length = 8797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7969 IQQATR 7974
>XP_006715481
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7934 IQQATR 7939
>XP_006715480
          Length = 8799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7934 IQQATR 7939
>XP_006715479
          Length = 8804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7976 IQQATR 7981
>XP_006715478
          Length = 8809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715477
          Length = 8822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7957 IQQATR 7962
>XP_006715476
          Length = 8823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715475
          Length = 8827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7976 IQQATR 7981
>XP_006715474
          Length = 8829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7964 IQQATR 7969
>XP_006715473
          Length = 8832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
>XP_006715472
          Length = 8839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7974 IQQATR 7979
>XP_006715471
          Length = 8842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7977 IQQATR 7982
>XP_006715470
          Length = 8846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    IQQATR 7
            IQQATR
Sbjct: 7981 IQQATR 7986
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.126    0.312 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 320,063
Number of extensions: 641
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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