Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              19     869
NP_005913                                                              19     869
XP_005267046                                                           19     869
XP_005267045                                                           19     869
NP_036553                                                              16    5631
NP_000050                                                              16    7355
NP_001028196                                                           16    7355
NP_036311                                                              16    7355
NP_001244919                                                           16    7355
NP_064450                                                              16    7355
NP_006730                                                              16    7355
NP_001245343                                                           16    7355
XP_006724305                                                           16    7355
XP_005255138                                                           16    7355
XP_005273257                                                           16    7355
NP_055203                                                              15    9605
NP_005344                                                              15    9605
NP_001008528                                                           15    9605
NP_060009                                                              15    9605
NP_001157888                                                           15    9605
XP_006724703                                                           15    9605
XP_005257439                                                           15    9605
XP_006721125                                                           15    9605
XP_006711338                                                           15    9605
NP_001094800                                                           15    9605
>NP_006715
          Length = 1558

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IQKSVRLF 9
            IQKSVRLF
Sbjct: 1247 IQKSVRLF 1254
>NP_005913
          Length = 1608

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IQKSVRLF 9
            IQKSVRLF
Sbjct: 1297 IQKSVRLF 1304
>XP_005267046
          Length = 1554

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IQKSVRLF 9
            IQKSVRLF
Sbjct: 1243 IQKSVRLF 1250
>XP_005267045
          Length = 1604

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    IQKSVRLF 9
            IQKSVRLF
Sbjct: 1293 IQKSVRLF 1300
>NP_036553
          Length = 1914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DIQKSVRL 8
           DI+KSV+L
Sbjct: 833 DIKKSVKL 840
>NP_000050
          Length = 3418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    IQKSVRLF 9
            +QK+V+LF
Sbjct: 1234 LQKAVKLF 1241
>NP_001028196
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DIQKSVRLF 9
           D+QK  RLF
Sbjct: 221 DLQKLSRLF 229
>NP_036311
          Length = 522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DIQKSVRLF 9
           D+QK  RLF
Sbjct: 300 DLQKLSRLF 308
>NP_001244919
          Length = 408

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DIQKSVRLF 9
           D+QK  RLF
Sbjct: 186 DLQKLSRLF 194
>NP_064450
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQKSVRL 8
           DIQ+++RL
Sbjct: 198 DIQQAIRL 205
>NP_006730
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DIQKSVRLF 9
           D+++++RLF
Sbjct: 636 DVEEALRLF 644
>NP_001245343
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIQKSVRLF 9
           D+Q+ +RLF
Sbjct: 216 DLQQPLRLF 224
>XP_006724305
          Length = 732

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   DIQKSVRLF 9
           D+++++RLF
Sbjct: 636 DVEEALRLF 644
>XP_005255138
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIQKSVRLF 9
           D+Q+ +RLF
Sbjct: 280 DLQQPLRLF 288
>XP_005273257
          Length = 1726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DIQKSVRL 8
           DIQ+++RL
Sbjct: 198 DIQQAIRL 205
>NP_055203
          Length = 756

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQKSVRLF 9
           +Q+S+RL+
Sbjct: 432 LQRSIRLY 439
>NP_005344
          Length = 1161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DIQKSVR 7
           DIQ SVR
Sbjct: 667 DIQSSVR 673
>NP_001008528
          Length = 204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DIQKSVRLF 9
           D+Q+ +RL+
Sbjct: 194 DVQEQLRLY 202
>NP_060009
          Length = 4116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    DIQKSVRLF 9
            D++K +RL+
Sbjct: 2295 DVEKCIRLW 2303
>NP_001157888
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DIQKSVRL 8
           DIQ +VRL
Sbjct: 116 DIQMAVRL 123
>XP_006724703
          Length = 154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DIQKSVRL 8
           DIQ +VRL
Sbjct: 116 DIQMAVRL 123
>XP_005257439
          Length = 247

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   DIQKSVRLF 9
           D+Q+ +RL+
Sbjct: 237 DVQEQLRLY 245
>XP_006721125
          Length = 4070

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    DIQKSVRLF 9
            D++K +RL+
Sbjct: 2249 DVEKCIRLW 2257
>XP_006711338
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   IQKSVRLF 9
           +Q+S+RL+
Sbjct: 432 LQRSIRLY 439
>NP_001094800
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  DIQKSVRLF 9
          ++ KS+R+F
Sbjct: 63 ELSKSIRVF 71
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.334    0.147    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 290,813
Number of extensions: 309
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package