Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_115803                                                              18    1135
NP_006696                                                              17    2528
NP_001277131                                                           17    4312
NP_849191                                                              17    4312
NP_001092105                                                           17    4312
NP_001028738                                                           16    5631
NP_055104                                                              16    5631
NP_001275683                                                           16    5631
NP_001028740                                                           16    5631
NP_060777                                                              16    5631
XP_006722033                                                           16    5631
XP_006722032                                                           16    5631
XP_006722031                                                           16    5631
XP_005258053                                                           16    5631
NP_001229759                                                           16    7355
NP_068586                                                              16    7355
NP_001229757                                                           16    7355
NP_976041                                                              16    7355
NP_003414                                                              16    7355
NP_001243582                                                           16    7355
NP_001243583                                                           16    7355
NP_001243580                                                           16    7355
NP_001258578" target = "next">NP_001258578                                                           16    7355
NP_001258567" target = "next">NP_001258567                                                           16    7355
NP_001243579                                                           16    7355
NP_001243578                                                           16    7355
NP_976042                                                              16    7355
NP_006515                                                              16    7355
NP_001243577                                                           16    7355
NP_001258568" target = "next">NP_001258568                                                           16    7355
NP_001136069                                                           16    7355
NP_848526                                                              16    7355
NP_976040                                                              16    7355
NP_976038                                                              16    7355
NP_976039                                                              16    7355
XP_005260114                                                           16    7355
XP_006718488                                                           16    7355
XP_005249324                                                           16    7355
XP_005249323                                                           16    7355
XP_006714986                                                           16    7355
NP_006822                                                              16    7355
NP_001265593                                                           15    9605
NP_975011                                                              15    9605
NP_001265606                                                           15    9605
NP_001265592                                                           15    9605
NP_001265607                                                           15    9605
NP_001265590                                                           15    9605
NP_001265591                                                           15    9605
NP_001258                                                              15    9605
XP_006723012                                                           15    9605
XP_006723011                                                           15    9605
XP_005260225                                                           15    9605
XP_005260224                                                           15    9605
XP_005260223                                                           15    9605
XP_006711445                                                           15    9605
XP_006711444                                                           15    9605
NP_006203                                                              15    9605
NP_001018063                                                           15    9605
>NP_115803
          Length = 1156

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           DIK IRVGE
Sbjct: 202 DIKRIRVGE 210
>NP_006696
          Length = 159

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          DI I+RVG+
Sbjct: 89 DIDIVRVGD 97
>NP_001277131
          Length = 869

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   DIKIIRVG 8
           DI+++R+G
Sbjct: 509 DIRVLRIG 516
>NP_849191
          Length = 994

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   DIKIIRVG 8
           DI+++R+G
Sbjct: 634 DIRVLRIG 641
>NP_001092105
          Length = 993

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   DIKIIRVG 8
           DI+++R+G
Sbjct: 634 DIRVLRIG 641
>NP_001028738
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>NP_055104
          Length = 641

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           DI+ IR+GE
Sbjct: 258 DIRKIRLGE 266
>NP_001275683
          Length = 650

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>NP_001028740
          Length = 691

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>NP_060777
          Length = 618

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>XP_006722033
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>XP_006722032
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>XP_006722031
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>XP_005258053
          Length = 681

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  DIKIIRVGE 9
          D++I+ VGE
Sbjct: 4  DVRILLVGE 12
>NP_001229759
          Length = 262

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DIKIIRV 7
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>NP_068586
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DIKIIRV 7
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>NP_001229757
          Length = 326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DIKIIRV 7
           D+KIIRV
Sbjct: 133 DMKIIRV 139
>NP_976041
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 152 DLKGVRLGE 160
>NP_003414
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 277 KIIRTGE 283
>NP_001243582
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 286 KIIRTGE 292
>NP_001243583
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 212 KIIRTGE 218
>NP_001243580
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 212 KIIRTGE 218
>NP_001258578" target = "next">NP_001258578
          Length = 172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 95  KIIRTGE 101
>NP_001258567" target = "next">NP_001258567
          Length = 287

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 210 KIIRTGE 216
>NP_001243579
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 271 KIIRTGE 277
>NP_001243578
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 271 KIIRTGE 277
>NP_976042
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 178 DLKGVRLGE 186
>NP_006515
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 216 KIIRTGE 222
>NP_001243577
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 271 KIIRTGE 277
>NP_001258568" target = "next">NP_001258568
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 242 KIIRTGE 248
>NP_001136069
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DIKIIRVG 8
           D+KI +VG
Sbjct: 259 DVKIYKVG 266
>NP_848526
          Length = 515

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DIKIIRVGE 9
           DIKI  +GE
Sbjct: 109 DIKICALGE 117
>NP_976040
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 152 DLKGVRLGE 160
>NP_976038
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 360 DLKGVRLGE 368
>NP_976039
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 152 DLKGVRLGE 160
>XP_005260114
          Length = 790

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KIIR GE
Sbjct: 286 KIIRTGE 292
>XP_006718488
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DIKIIRVG 8
           D+KI +VG
Sbjct: 323 DVKIYKVG 330
>XP_005249324
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DIKIIRV 7
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>XP_005249323
          Length = 299

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DIKIIRV 7
           D+KIIRV
Sbjct: 106 DMKIIRV 112
>XP_006714986
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIKIIRVGE 9
           D+K +R+GE
Sbjct: 152 DLKGVRLGE 160
>NP_006822
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DIKIIRVG 8
           D+KI +VG
Sbjct: 323 DVKIYKVG 330
>NP_001265593
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 324 KIIHVGE 330
>NP_975011
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 397 KIIHVGE 403
>NP_001265606
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 356 KIIHVGE 362
>NP_001265592
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>NP_001265607
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>NP_001265590
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 356 KIIHVGE 362
>NP_001265591
          Length = 618

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 356 KIIHVGE 362
>NP_001258
          Length = 359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DIKIIRVG 8
           DI+++R G
Sbjct: 110 DIRVLRAG 117
>XP_006723012
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>XP_006723011
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>XP_005260225
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>XP_005260224
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 312 KIIHVGE 318
>XP_005260223
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KIIRVGE 9
           KII VGE
Sbjct: 397 KIIHVGE 403
>XP_006711445
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IKIIRVGE 9
           IK+I VG+
Sbjct: 118 IKVINVGQ 125
>XP_006711444
          Length = 407

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IKIIRVGE 9
           IK+I VG+
Sbjct: 118 IKVINVGQ 125
>NP_006203
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IKIIRVGE 9
           IK+I VG+
Sbjct: 216 IKVINVGQ 223
>NP_001018063
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IKIIRVGE 9
           IK+I VG+
Sbjct: 216 IKVINVGQ 223
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.157    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 434,618
Number of extensions: 1417
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package