Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185763                                                           22     134
NP_055459                                                              22     134
XP_006711718                                                           22     134
XP_006711716                                                           22     134
XP_006711715                                                           22     134
XP_006711714                                                           22     134
XP_006711713                                                           22     134
XP_006711712                                                           22     134
XP_006711710                                                           22     134
XP_006711709                                                           22     134
XP_005277503                                                           22     134
XP_005273038                                                           22     134
XP_006711708                                                           22     134
XP_005277500                                                           22     134
XP_006711707                                                           22     134
XP_005277499                                                           22     134
XP_006711706                                                           22     134
XP_006711705                                                           22     134
XP_006710142                                                           22     134
XP_006710141                                                           22     134
NP_003493                                                              18    1935
NP_851393                                                              18    1935
XP_005255667                                                           18    1935
XP_005255666                                                           18    1935
XP_005255665                                                           18    1935
XP_005255664                                                           18    1935
NP_001449                                                              16    5631
NP_001120959                                                           16    5631
NP_000558                                                              16    5631
NP_001188336                                                           16    5631
NP_872337                                                              16    5631
NP_001026881                                                           16    5631
NP_001128625                                                           16    5631
NP_036307                                                              16    5631
NP_208385                                                              16    5631
XP_006721228                                                           16    5631
XP_005256347                                                           16    5631
XP_005256346                                                           16    5631
XP_005256345                                                           16    5631
XP_005252908                                                           16    5631
XP_005273523                                                           16    5631
XP_006716387                                                           16    5631
XP_005273522                                                           16    5631
XP_005273521                                                           16    5631
XP_005273520                                                           16    5631
XP_006716386                                                           16    5631
XP_006715973                                                           16    5631
XP_006714955                                                           16    5631
NP_001121903                                                           16    5631
NP_001128626                                                           16    5631
NP_056174                                                              16    5631
NP_005173                                                              16    7355
NP_001014435                                                           16    7355
NP_114432                                                              16    7355
NP_000405                                                              16    7355
NP_001186221                                                           16    7355
NP_001186220                                                           16    7355
XP_005256193                                                           16    7355
XP_006721330                                                           16    7355
NP_149419                                                              16    7355
NP_004604                                                              15    9605
XP_005268801                                                           15    9605
XP_005268800                                                           15    9605
XP_005268799                                                           15    9605
NP_056090                                                              15    9605
>NP_001185763
          Length = 2362

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1180 DLGATFTVD 1188
>NP_055459
          Length = 2346

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1180 DLGATFTVD 1188
>XP_006711718
          Length = 1436

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DIGATFTVD 9
           D+GATFTVD
Sbjct: 187 DLGATFTVD 195
>XP_006711716
          Length = 2411

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1246 DLGATFTVD 1254
>XP_006711715
          Length = 2428

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1180 DLGATFTVD 1188
>XP_006711714
          Length = 2429

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1180 DLGATFTVD 1188
>XP_006711713
          Length = 2432

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1183 DLGATFTVD 1191
>XP_006711712
          Length = 2473

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006711710
          Length = 2494

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1246 DLGATFTVD 1254
>XP_006711709
          Length = 2495

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1246 DLGATFTVD 1254
>XP_005277503
          Length = 2498

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_005273038
          Length = 2509

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006711708
          Length = 2512

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_005277500
          Length = 2525

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006711707
          Length = 2553

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_005277499
          Length = 2561

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006711706
          Length = 2591

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006711705
          Length = 2592

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    DIGATFTVD 9
            D+GATFTVD
Sbjct: 1343 DLGATFTVD 1351
>XP_006710142
          Length = 671

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DIGATFTVD 9
           D+GATFTVD
Sbjct: 132 DLGATFTVD 140
>XP_006710141
          Length = 672

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DIGATFTVD 9
           D+GATFTVD
Sbjct: 132 DLGATFTVD 140
>NP_003493
          Length = 862

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 11 DLGASFTED 19
>NP_851393
          Length = 826

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 11 DLGASFTED 19
>XP_005255667
          Length = 473

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 60 DLGASFTED 68
>XP_005255666
          Length = 862

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 11 DLGASFTED 19
>XP_005255665
          Length = 875

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 60 DLGASFTED 68
>XP_005255664
          Length = 911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  DIGATFTVD 9
          D+GA+FT D
Sbjct: 60 DLGASFTED 68
>NP_001449
          Length = 2725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ATFTVD 9
            ATFTVD
Sbjct: 1174 ATFTVD 1179
>NP_001120959
          Length = 2692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ATFTVD 9
            ATFTVD
Sbjct: 1174 ATFTVD 1179
>NP_000558
          Length = 224

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DIGATFTV 8
          DIG +FTV
Sbjct: 88 DIGYSFTV 95
>NP_001188336
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 593 DCGKTFTV 600
>NP_872337
          Length = 729

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 565 DCGKTFTV 572
>NP_001026881
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGATFTV 8
           IG TFTV
Sbjct: 260 IGGTFTV 266
>NP_001128625
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>NP_036307
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IGATFT 7
           IGATFT
Sbjct: 241 IGATFT 246
>NP_208385
          Length = 415

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IGATFT 7
           IGATFT
Sbjct: 241 IGATFT 246
>XP_006721228
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 425 DCGKTFTV 432
>XP_005256347
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 537 DCGKTFTV 544
>XP_005256346
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 537 DCGKTFTV 544
>XP_005256345
          Length = 757

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DIGATFTV 8
           D G TFTV
Sbjct: 593 DCGKTFTV 600
>XP_005252908
          Length = 466

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   IGATFT 7
           IGATFT
Sbjct: 236 IGATFT 241
>XP_005273523
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>XP_006716387
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>XP_005273522
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>XP_005273521
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 365 IGASFTV 371
>XP_005273520
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 365 IGASFTV 371
>XP_006716386
          Length = 502

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 365 IGASFTV 371
>XP_006715973
          Length = 2632

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    ATFTVD 9
            ATFTVD
Sbjct: 1081 ATFTVD 1086
>XP_006714955
          Length = 198

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   IGATFTV 8
           IG TFTV
Sbjct: 168 IGGTFTV 174
>NP_001121903
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>NP_001128626
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>NP_056174
          Length = 492

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   IGATFTV 8
           IGA+FTV
Sbjct: 355 IGASFTV 361
>NP_005173
          Length = 264

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DIGATFTVD 9
           D+G+  TVD
Sbjct: 104 DVGSEHTVD 112
>NP_001014435
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DIGATFTVD 9
          D+G+  TVD
Sbjct: 48 DVGSEHTVD 56
>NP_114432
          Length = 1249

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   DIGATFTV 8
           ++G TFT+
Sbjct: 626 ELGVTFTI 633
>NP_000405
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIGATFTVD 9
           +IGA +T+D
Sbjct: 659 NIGAKWTID 667
>NP_001186221
          Length = 718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIGATFTVD 9
           +IGA +T+D
Sbjct: 641 NIGAKWTID 649
>NP_001186220
          Length = 761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DIGATFTVD 9
           +IGA +T+D
Sbjct: 684 NIGAKWTID 692
>XP_005256193
          Length = 208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DIGATFTVD 9
          D+G+  TVD
Sbjct: 48 DVGSEHTVD 56
>XP_006721330
          Length = 186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DIGATFTVD 9
          D+G+  TVD
Sbjct: 48 DVGSEHTVD 56
>NP_149419
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  DIGATFT 7
          D+G TFT
Sbjct: 68 DLGMTFT 74
>NP_004604
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   GATFTVD 9
           G TFTV+
Sbjct: 619 GCTFTVE 625
>XP_005268801
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   IGATFTVD 9
           IGA FT D
Sbjct: 853 IGAAFTDD 860
>XP_005268800
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   IGATFTVD 9
           IGA FT D
Sbjct: 854 IGAAFTDD 861
>XP_005268799
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IGATFTVD 9
            IGA FT D
Sbjct: 1042 IGAAFTDD 1049
>NP_056090
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    IGATFTVD 9
            IGA FT D
Sbjct: 1041 IGAAFTDD 1048
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.142    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 414,089
Number of extensions: 1014
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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