Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     509
NP_001087241                                                           20     509
XP_005265799                                                           20     509
XP_005265798                                                           20     509
XP_005265797                                                           20     509
NP_001032249                                                           17    4312
NP_001269657                                                           17    4312
NP_689495                                                              17    4312
XP_005250953                                                           17    4312
XP_005250952                                                           17    4312
XP_005250951                                                           17    4312
XP_005247960                                                           17    4312
NP_861452                                                              17    4312
NP_853553                                                              16    5631
NP_694984                                                              16    5631
NP_037396                                                              16    5631
NP_937791                                                              16    5631
XP_005262172                                                           16    5631
XP_005262170                                                           16    5631
XP_005271586                                                           16    5631
XP_005269585                                                           16    5631
XP_005264449                                                           16    5631
NP_002221                                                              16    7355
NP_068831                                                              16    7355
NP_001164409                                                           16    7355
NP_057452                                                              16    7355
NP_001240318                                                           16    7355
NP_597705                                                              16    7355
NP_777635                                                              16    7355
NP_001244307                                                           16    7355
NP_001244308                                                           16    7355
NP_689723                                                              16    7355
NP_037437                                                              16    7355
NP_079452                                                              16    7355
NP_001244311                                                           16    7355
XP_005261584                                                           16    7355
XP_005260736                                                           16    7355
XP_006723615                                                           16    7355
XP_005260735                                                           16    7355
XP_006722829                                                           16    7355
XP_006722507                                                           16    7355
XP_006722506                                                           16    7355
XP_005258307                                                           16    7355
XP_006721941                                                           16    7355
XP_006721940                                                           16    7355
XP_006721939                                                           16    7355
XP_006721938                                                           16    7355
XP_006721937                                                           16    7355
XP_006721936                                                           16    7355
XP_006721935                                                           16    7355
XP_006721934                                                           16    7355
XP_005257370                                                           16    7355
NP_073153                                                              15    9605
NP_001121182                                                           15    9605
NP_001121181                                                           15    9605
NP_001121180                                                           15    9605
NP_005798                                                              15    9605
NP_000880                                                              15    9605
XP_006726447                                                           15    9605
XP_005276263                                                           15    9605
XP_006726445                                                           15    9605
XP_006719439                                                           15    9605
XP_005268909                                                           15    9605
XP_005268908                                                           15    9605
XP_006712754                                                           15    9605
XP_006712753                                                           15    9605
XP_005264736                                                           15    9605
XP_006712220                                                           15    9605
XP_005244879                                                           15    9605
XP_006711171                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           DHSVRIN V
Sbjct: 952 DHSVRINSV 960
>NP_001087241
          Length = 972

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           DHSVRIN V
Sbjct: 948 DHSVRINSV 956
>XP_005265799
          Length = 973

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           DHSVRIN V
Sbjct: 949 DHSVRINSV 957
>XP_005265798
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           DHSVRIN V
Sbjct: 952 DHSVRINSV 960
>XP_005265797
          Length = 977

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           DHSVRIN V
Sbjct: 953 DHSVRINSV 961
>NP_001032249
          Length = 480

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DHSVRINY 8
           +HSVRI Y
Sbjct: 416 EHSVRILY 423
>NP_001269657
          Length = 442

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DHSVRINY 8
           +HSVRI Y
Sbjct: 378 EHSVRILY 385
>NP_689495
          Length = 480

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DHSVRINY 8
           +HSVRI Y
Sbjct: 416 EHSVRILY 423
>XP_005250953
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           H V+INY
Sbjct: 437 HEVKINY 443
>XP_005250952
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           H V+INY
Sbjct: 583 HEVKINY 589
>XP_005250951
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           H V+INY
Sbjct: 625 HEVKINY 631
>XP_005247960
          Length = 463

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DHSVRINY 8
           +HSVRI Y
Sbjct: 399 EHSVRILY 406
>NP_861452
          Length = 723

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           H V+INY
Sbjct: 688 HEVKINY 694
>NP_853553
          Length = 410

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DHSVRI 6
          DHSVR+
Sbjct: 86 DHSVRV 91
>NP_694984
          Length = 1802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           DH +RI Y+
Sbjct: 339 DHVIRIYYL 347
>NP_037396
          Length = 483

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DHSVRI 6
           DHS+RI
Sbjct: 260 DHSIRI 265
>NP_937791
          Length = 756

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DHSVRI 6
           DHSVR+
Sbjct: 122 DHSVRV 127
>XP_005262172
          Length = 1631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           DH +RI Y+
Sbjct: 168 DHVIRIYYL 176
>XP_005262170
          Length = 1752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           DH +RI Y+
Sbjct: 339 DHVIRIYYL 347
>XP_005271586
          Length = 420

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DHSVRI 6
           DHS+RI
Sbjct: 260 DHSIRI 265
>XP_005269585
          Length = 704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DHSVRI 6
           DHSVR+
Sbjct: 122 DHSVRV 127
>XP_005264449
          Length = 467

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DHSVRI 6
           DHSVR+
Sbjct: 143 DHSVRV 148
>NP_002221
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>NP_068831
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>NP_001164409
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DHSVRINYV 9
           DH V I YV
Sbjct: 324 DHCVVIKYV 332
>NP_057452
          Length = 558

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DHSVRINYV 9
           DH V I YV
Sbjct: 378 DHCVVIKYV 386
>NP_001240318
          Length = 430

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DHSVRINYV 9
           DH V I YV
Sbjct: 250 DHCVVIKYV 258
>NP_597705
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DHSVRINYV 9
           D+SV I+Y+
Sbjct: 287 DNSVAIHYI 295
>NP_777635
          Length = 400

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DHSVRIN 7
           +HSV+IN
Sbjct: 279 EHSVQIN 285
>NP_001244307
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DHSVRIN 7
           +HSV+IN
Sbjct: 202 EHSVQIN 208
>NP_001244308
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DHSVRIN 7
           +HSV+IN
Sbjct: 220 EHSVQIN 226
>NP_689723
          Length = 307

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           DH  R+N+V
Sbjct: 272 DHIQRMNFV 280
>NP_037437
          Length = 376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           D S+R+ YV
Sbjct: 256 DVSIRVKYV 264
>NP_079452
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  DHSVRINY 8
          DH  R+N+
Sbjct: 56 DHFARVNF 63
>NP_001244311
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DHSVRIN 7
           +HSV+IN
Sbjct: 220 EHSVQIN 226
>XP_005261584
          Length = 353

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DHSVRIN 7
           +HSV+IN
Sbjct: 220 EHSVQIN 226
>XP_005260736
          Length = 1033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  DHSVRINY 8
          DH  R+N+
Sbjct: 56 DHFARVNF 63
>XP_006723615
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  DHSVRINY 8
          DH  R+N+
Sbjct: 56 DHFARVNF 63
>XP_005260735
          Length = 1398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 1  DHSVRINY 8
          DH  R+N+
Sbjct: 72 DHFARVNF 79
>XP_006722829
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DHSVRINYV 9
           DH V I YV
Sbjct: 573 DHCVVIKYV 581
>XP_006722507
          Length = 302

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           D S+R+ YV
Sbjct: 182 DVSIRVKYV 190
>XP_006722506
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           D S+R+ YV
Sbjct: 287 DVSIRVKYV 295
>XP_005258307
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DHSVRINYV 9
           D S+R+ YV
Sbjct: 292 DVSIRVKYV 300
>XP_006721941
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721940
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721939
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721938
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721937
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721936
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721935
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 491 NSVRLNY 497
>XP_006721934
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 512 NSVRLNY 518
>XP_005257370
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HSVRINY 8
           +SVR+NY
Sbjct: 512 NSVRLNY 518
>NP_073153
          Length = 1944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HSVRINYV 9
            H VR+N V
Sbjct: 1045 HPVRVNVV 1052
>NP_001121182
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1180 HTIRIQY 1186
>NP_001121181
          Length = 1311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1221 HTIRIQY 1227
>NP_001121180
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1273 HTIRIQY 1279
>NP_005798
          Length = 1404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1314 HTIRIQY 1320
>NP_000880
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           HSVRI +
Sbjct: 187 HSVRIGF 193
>XP_006726447
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  HSVRINYV 9
          H VR+N V
Sbjct: 30 HPVRVNVV 37
>XP_005276263
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  HSVRINYV 9
          H VR+N V
Sbjct: 30 HPVRVNVV 37
>XP_006726445
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HSVRINYV 9
           H VR+N V
Sbjct: 308 HPVRVNVV 315
>XP_006719439
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           HSVRI +
Sbjct: 187 HSVRIGF 193
>XP_005268909
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           HSVRI +
Sbjct: 187 HSVRIGF 193
>XP_005268908
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSVRINY 8
           HSVRI +
Sbjct: 187 HSVRIGF 193
>XP_006712754
          Length = 1784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HSVRINYV 9
           H VR+N V
Sbjct: 885 HPVRVNVV 892
>XP_006712753
          Length = 1846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HSVRINYV 9
           H VR+N V
Sbjct: 947 HPVRVNVV 954
>XP_005264736
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HSVRINYV 9
           H VR+N V
Sbjct: 333 HPVRVNVV 340
>XP_006712220
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   HSVRINYV 9
           H VR+N V
Sbjct: 308 HPVRVNVV 315
>XP_005244879
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1271 HTIRIQY 1277
>XP_006711171
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2    HSVRINY 8
            H++RI Y
Sbjct: 1291 HTIRIQY 1297
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.139    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 500,732
Number of extensions: 1274
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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