Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     229
NP_671714                                                              21     229
XP_006715890                                                           21     229
XP_005250160                                                           21     229
XP_005250159                                                           21     229
NP_004790                                                              17    2528
NP_015563                                                              17    2528
XP_006726591                                                           17    3301
XP_006718462                                                           17    3301
XP_006710008                                                           17    3301
NP_064630                                                              16    5631
XP_005267114                                                           16    5631
NP_005264                                                              16    7355
NP_056504                                                              16    7355
XP_005250036                                                           16    7355
XP_005250035                                                           16    7355
XP_005250034                                                           16    7355
XP_005250033                                                           16    7355
NP_000932                                                              15    9605
NP_115820                                                              15    9605
NP_112190                                                              15    9605
NP_031382                                                              15    9605
XP_005250289                                                           15    9605
XP_005263256                                                           15    9605
NP_001103447                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DGVITQLTA 9
           DG+ITQLTA
Sbjct: 204 DGIITQLTA 212
>NP_671714
          Length = 3899

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DGVITQLTA 9
           DG+ITQLTA
Sbjct: 204 DGIITQLTA 212
>XP_006715890
          Length = 3860

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DGVITQLTA 9
           DG+ITQLTA
Sbjct: 204 DGIITQLTA 212
>XP_005250160
          Length = 3939

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DGVITQLTA 9
           DG+ITQLTA
Sbjct: 204 DGIITQLTA 212
>XP_005250159
          Length = 3952

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DGVITQLTA 9
           DG+ITQLTA
Sbjct: 204 DGIITQLTA 212
>NP_004790
          Length = 1425

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DGVITQLTA 9
            DGV+ Q+TA
Sbjct: 1224 DGVMVQITA 1232
>NP_015563
          Length = 1366

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DGVITQLTA 9
            DGV+ Q+TA
Sbjct: 1165 DGVMVQITA 1173
>XP_006726591
          Length = 352

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV+ QLT
Sbjct: 77 DGVVIQLT 84
>XP_006718462
          Length = 4966

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGVITQLT 8
           DGV+ QLT
Sbjct: 141 DGVVIQLT 148
>XP_006710008
          Length = 2014

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGVITQLT 8
           DGV+ QLT
Sbjct: 141 DGVVIQLT 148
>NP_064630
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    GVITQLTA 9
            GV+TQL A
Sbjct: 1021 GVVTQLPA 1028
>XP_005267114
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    GVITQLTA 9
            GV+TQL A
Sbjct: 1021 GVVTQLPA 1028
>NP_005264
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  DGVITQLTA 9
          D  +TQ+TA
Sbjct: 27 DSTLTQITA 35
>NP_056504
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV TQ+T
Sbjct: 86 DGVRTQVT 93
>XP_005250036
          Length = 742

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV TQ+T
Sbjct: 86 DGVRTQVT 93
>XP_005250035
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV TQ+T
Sbjct: 86 DGVRTQVT 93
>XP_005250034
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV TQ+T
Sbjct: 86 DGVRTQVT 93
>XP_005250033
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  DGVITQLT 8
          DGV TQ+T
Sbjct: 86 DGVRTQVT 93
>NP_000932
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DGVITQL 7
           DG +TQL
Sbjct: 588 DGALTQL 594
>NP_115820
          Length = 1834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DGVITQ 6
           DGV+TQ
Sbjct: 731 DGVLTQ 736
>NP_112190
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   DGVITQLTA 9
           DG   QLTA
Sbjct: 280 DGAAPQLTA 288
>NP_031382
          Length = 1761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGVITQLTA 9
            +  ITQLTA
Sbjct: 1587 NSTITQLTA 1595
>XP_005250289
          Length = 1761

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGVITQLTA 9
            +  ITQLTA
Sbjct: 1587 NSTITQLTA 1595
>XP_005263256
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVITQLTA 9
           G+ITQL +
Sbjct: 877 GIITQLAS 884
>NP_001103447
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   GVITQLTA 9
           G+ITQL +
Sbjct: 877 GIITQLAS 884
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.132    0.344 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 344,864
Number of extensions: 373
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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