Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              20     509
NP_653080                                                              20     509
XP_005267292                                                           20     509
XP_005267291                                                           20     509
XP_005267290                                                           20     509
NP_001120843                                                           18    1482
NP_001120842                                                           18    1482
NP_061189                                                              18    1482
NP_056262                                                              17    3301
XP_005263454                                                           17    3301
XP_005263453                                                           17    3301
NP_001013764                                                           16    5631
NP_055062                                                              16    5631
XP_005256009                                                           16    5631
XP_006714485                                                           16    5631
XP_005263418                                                           16    5631
XP_005263417                                                           16    5631
XP_006714484                                                           16    5631
XP_005263416                                                           16    5631
XP_006714483                                                           16    5631
XP_005263415                                                           16    5631
NP_001013002                                                           16    5631
NP_060217                                                              16    7355
NP_065741                                                              16    7355
NP_001030014                                                           16    7355
NP_001180209                                                           15    9605
NP_001180207                                                           15    9605
NP_001180208                                                           15    9605
NP_006657                                                              15    9605
NP_000099                                                              15    9605
NP_003627                                                              15    9605
NP_001186791                                                           15    9605
NP_001276680                                                           15    9605
NP_001276679                                                           15    9605
NP_742128                                                              15    9605
NP_001186792                                                           15    9605
NP_001276681                                                           15    9605
NP_001186789                                                           15    9605
NP_001186790                                                           15    9605
NP_055850                                                              15    9605
XP_006724984                                                           15    9605
XP_006724983                                                           15    9605
XP_006724982                                                           15    9605
XP_006724981                                                           15    9605
XP_006724980                                                           15    9605
XP_006724979                                                           15    9605
XP_006724978                                                           15    9605
XP_006724977                                                           15    9605
XP_006724976                                                           15    9605
XP_005274595                                                           15    9605
XP_005260398                                                           15    9605
XP_006723812                                                           15    9605
XP_006723811                                                           15    9605
XP_006723810                                                           15    9605
XP_005260400                                                           15    9605
XP_005258485                                                           15    9605
XP_005258484                                                           15    9605
XP_005258483                                                           15    9605
XP_006712096                                                           15    9605
XP_005264430                                                           15    9605
XP_006712093                                                           15    9605
XP_005264429                                                           15    9605
XP_005263571                                                           15    9605
XP_005263570                                                           15    9605
XP_005263569                                                           15    9605
XP_005263568                                                           15    9605
NP_849150                                                              15    9605
NP_001098099                                                           15    9605
NP_060772                                                              15    9605
NP_060022                                                              15    9605
NP_001229267                                                           15    9605
>NP_005091
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKAEV SE
Sbjct: 340 DGKAEVASE 348
>NP_653080
          Length = 1684

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKAEV SE
Sbjct: 242 DGKAEVASE 250
>XP_005267292
          Length = 1677

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKAEV SE
Sbjct: 235 DGKAEVASE 243
>XP_005267291
          Length = 1684

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKAEV SE
Sbjct: 242 DGKAEVASE 250
>XP_005267290
          Length = 1782

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKAEV SE
Sbjct: 340 DGKAEVASE 348
>NP_001120843
          Length = 408

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DGKAEVVSE 9
          DGKA +VSE
Sbjct: 64 DGKASLVSE 72
>NP_001120842
          Length = 420

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  DGKAEVVSE 9
          DGKA +VSE
Sbjct: 76 DGKASLVSE 84
>NP_061189
          Length = 454

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DGKA +VSE
Sbjct: 110 DGKASLVSE 118
>NP_056262
          Length = 1602

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DGKAEVVSE 9
            DG A++VSE
Sbjct: 1254 DGSADLVSE 1262
>XP_005263454
          Length = 1324

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DG A++VSE
Sbjct: 976 DGSADLVSE 984
>XP_005263453
          Length = 1613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    DGKAEVVSE 9
            DG A++VSE
Sbjct: 1265 DGSADLVSE 1273
>NP_001013764
          Length = 1271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGKAEVVS 8
           DGK EVV+
Sbjct: 963 DGKLEVVA 970
>NP_055062
          Length = 1499

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 187 DGKAEIL 193
>XP_005256009
          Length = 326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DG+AEV +E
Sbjct: 220 DGEAEVEAE 228
>XP_006714485
          Length = 1585

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 232 DGKAEIL 238
>XP_005263418
          Length = 1654

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 342 DGKAEIL 348
>XP_005263417
          Length = 1660

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 348 DGKAEIL 354
>XP_006714484
          Length = 1685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 348 DGKAEIL 354
>XP_005263416
          Length = 1693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 348 DGKAEIL 354
>XP_006714483
          Length = 1695

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 342 DGKAEIL 348
>XP_005263415
          Length = 1701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DGKAE++
Sbjct: 348 DGKAEIL 354
>NP_001013002
          Length = 317

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DGKAEVVSE 9
           DG+AEV +E
Sbjct: 211 DGEAEVEAE 219
>NP_060217
          Length = 2542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GKAEVVS 8
            G+AEVVS
Sbjct: 1235 GRAEVVS 1241
>NP_065741
          Length = 2617

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    GKAEVVS 8
            G+AEVVS
Sbjct: 1235 GRAEVVS 1241
>NP_001030014
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGKAEVV 7
           DGK EVV
Sbjct: 541 DGKREVV 547
>NP_001180209
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GKAEVVSE 9
           G+A VVSE
Sbjct: 385 GQANVVSE 392
>NP_001180207
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GKAEVVSE 9
           G+A VVSE
Sbjct: 474 GQANVVSE 481
>NP_001180208
          Length = 489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GKAEVVSE 9
           G+A VVSE
Sbjct: 423 GQANVVSE 430
>NP_006657
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           +GKAE++
Sbjct: 286 EGKAEII 292
>NP_000099
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GKAEVVS 8
           GKAEV++
Sbjct: 299 GKAEVIT 305
>NP_003627
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>NP_001186791
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   GKAEVV 7
           GKAEVV
Sbjct: 126 GKAEVV 131
>NP_001276680
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GKAEVVS 8
           GKAEV++
Sbjct: 276 GKAEVIT 282
>NP_001276679
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GKAEVVS 8
           GKAEV++
Sbjct: 200 GKAEVIT 206
>NP_742128
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 79 GKAEVV 84
>NP_001186792
          Length = 300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 26 GKAEVV 31
>NP_001276681
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   GKAEVVS 8
           GKAEV++
Sbjct: 251 GKAEVIT 257
>NP_001186789
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>NP_001186790
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>NP_055850
          Length = 956

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_006724984
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 20 GKAEVIN 26
>XP_006724983
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724982
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724981
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724980
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724979
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724978
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724977
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_006724976
          Length = 565

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  GKAEVVS 8
          GKAEV++
Sbjct: 68 GKAEVIN 74
>XP_005274595
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GKAEVVSE 9
           G+A VVSE
Sbjct: 474 GQANVVSE 481
>XP_005260398
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_006723812
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_006723811
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_006723810
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_005260400
          Length = 969

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           DG+AE++
Sbjct: 174 DGQAEII 180
>XP_005258485
          Length = 418

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           +GKAE++
Sbjct: 241 EGKAEII 247
>XP_005258484
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           +GKAE++
Sbjct: 252 EGKAEII 258
>XP_005258483
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DGKAEVV 7
           +GKAE++
Sbjct: 252 EGKAEII 258
>XP_006712096
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGKAEVVS 8
           +GK EVVS
Sbjct: 631 NGKLEVVS 638
>XP_005264430
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGKAEVVS 8
           +GK EVVS
Sbjct: 873 NGKLEVVS 880
>XP_006712093
          Length = 1460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DGKAEVVS 8
            +GK EVVS
Sbjct: 1301 NGKLEVVS 1308
>XP_005264429
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DGKAEVVS 8
            +GK EVVS
Sbjct: 1301 NGKLEVVS 1308
>XP_005263571
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 79 GKAEVV 84
>XP_005263570
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>XP_005263569
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>XP_005263568
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  GKAEVV 7
          GKAEVV
Sbjct: 93 GKAEVV 98
>NP_849150
          Length = 1445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    KAEVVSE 9
            KA+VVSE
Sbjct: 1093 KAQVVSE 1099
>NP_001098099
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DGKAEVVSE 9
           DG  E+V E
Sbjct: 282 DGDGEIVDE 290
>NP_060772
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   DGKAEVVSE 9
           DG  E+V E
Sbjct: 282 DGDGEIVDE 290
>NP_060022
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DGKAEVVS 8
            +GK EVVS
Sbjct: 1287 NGKLEVVS 1294
>NP_001229267
          Length = 1453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    DGKAEVVS 8
            +GK EVVS
Sbjct: 1282 NGKLEVVS 1289
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.117    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 446,707
Number of extensions: 705
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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