Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138389                                                           19     869
NP_001138386                                                           19     869
NP_001138387                                                           19     869
NP_000132                                                              19     869
NP_075259                                                              19     869
NP_001138391                                                           19     869
NP_001138385                                                           19     869
NP_075418                                                              19     869
XP_006717776                                                           19     869
XP_006717774                                                           19     869
XP_006717773                                                           19     869
XP_006717772                                                           19     869
XP_006717771                                                           19     869
NP_055794                                                              17    4312
NP_055663                                                              17    4312
NP_055664                                                              17    4312
NP_001243546                                                           17    4312
NP_006650                                                              17    4312
XP_005255055                                                           17    4312
XP_005255054                                                           17    4312
XP_006717659                                                           17    4312
XP_005248527                                                           17    4312
NP_002834                                                              16    5631
NP_003310                                                              16    5631
NP_597676                                                              16    5631
NP_001243779                                                           16    5631
NP_596869                                                              16    5631
XP_006718332                                                           16    5631
XP_005246888                                                           16    5631
XP_006712788                                                           16    5631
XP_006712787                                                           16    5631
XP_006712786                                                           16    5631
NP_001254479                                                           16    5631
NP_597681                                                              16    5631
NP_001254772                                                           16    7355
NP_004889                                                              16    7355
NP_631938                                                              16    7355
XP_005271912                                                           16    7355
XP_005271916                                                           16    7355
XP_005271914                                                           16    7355
XP_006714587                                                           16    7355
XP_005271913                                                           16    7355
XP_006714117                                                           16    7355
XP_005265844                                                           16    7355
NP_001245143                                                           15    9605
NP_001245144                                                           15    9605
NP_001245145                                                           15    9605
NP_001550                                                              15    9605
NP_859070                                                              15    9605
NP_001231                                                              15    9605
XP_006710680                                                           15    9605
XP_005270885                                                           15    9605
XP_005270884                                                           15    9605
XP_005270882                                                           15    9605
XP_005245884                                                           15    9605
XP_005245882                                                           15    9605
XP_006710614                                                           15    9605
XP_005245881                                                           15    9605
XP_005245880                                                           15    9605
XP_006710613                                                           15    9605
XP_005245879                                                           15    9605
>NP_001138389
          Length = 705

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 138 DGAEDFVSE 146
>NP_001138386
          Length = 709

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 138 DGAEDFVSE 146
>NP_001138387
          Length = 707

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  DGAEVFVSE 9
          DGAE FVSE
Sbjct: 49 DGAEDFVSE 57
>NP_000132
          Length = 821

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 138 DGAEDFVSE 146
>NP_075259
          Length = 822

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 138 DGAEDFVSE 146
>NP_001138391
          Length = 680

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  DGAEVFVSE 9
          DGAE FVSE
Sbjct: 49 DGAEDFVSE 57
>NP_001138385
          Length = 769

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 138 DGAEDFVSE 146
>NP_075418
          Length = 732

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  DGAEVFVSE 9
          DGAE FVSE
Sbjct: 49 DGAEDFVSE 57
>XP_006717776
          Length = 806

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 157 DGAEDFVSE 165
>XP_006717774
          Length = 752

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  DGAEVFVSE 9
          DGAE FVSE
Sbjct: 68 DGAEDFVSE 76
>XP_006717773
          Length = 807

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 157 DGAEDFVSE 165
>XP_006717772
          Length = 838

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 157 DGAEDFVSE 165
>XP_006717771
          Length = 839

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DGAE FVSE
Sbjct: 157 DGAEDFVSE 165
>NP_055794
          Length = 727

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 165 DGVEVFV 171
>NP_055663
          Length = 683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 122 DGVEVFV 128
>NP_055664
          Length = 742

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 179 DGVEVFV 185
>NP_001243546
          Length = 930

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DGAEVFV 7
          DGAEV++
Sbjct: 23 DGAEVYI 29
>NP_006650
          Length = 902

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DGAEVFV 7
          DGAEV++
Sbjct: 23 DGAEVYI 29
>XP_005255055
          Length = 683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 122 DGVEVFV 128
>XP_005255054
          Length = 683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 122 DGVEVFV 128
>XP_006717659
          Length = 902

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  DGAEVFV 7
          DGAEV++
Sbjct: 23 DGAEVYI 29
>XP_005248527
          Length = 676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DGAEVFV 7
           DG EVFV
Sbjct: 165 DGVEVFV 171
>NP_002834
          Length = 1337

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGAEVFVS 8
           DGAE +VS
Sbjct: 949 DGAESYVS 956
>NP_003310
          Length = 26926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GAEVFVSE 9
            G EVFV E
Sbjct: 5262 GVEVFVGE 5269
>NP_597676
          Length = 27051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GAEVFVSE 9
            G EVFV E
Sbjct: 5387 GVEVFVGE 5394
>NP_001243779
          Length = 34350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2     GAEVFVSE 9
             G EVFV E
Sbjct: 12686 GVEVFVGE 12693
>NP_596869
          Length = 33423

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2     GAEVFVSE 9
             G EVFV E
Sbjct: 11759 GVEVFVGE 11766
>XP_006718332
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DGAEVFVS 8
           DGAE +VS
Sbjct: 944 DGAESYVS 951
>XP_005246888
          Length = 22663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GAEVFVSE 9
            G EVFV E
Sbjct: 999  GVEVFVGE 1006
>XP_006712788
          Length = 24022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GAEVFVSE 9
            G EVFV E
Sbjct: 2358 GVEVFVGE 2365
>XP_006712787
          Length = 33978

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2     GAEVFVSE 9
             G EVFV E
Sbjct: 12314 GVEVFVGE 12321
>XP_006712786
          Length = 35484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2     GAEVFVSE 9
             G EVFV E
Sbjct: 13820 GVEVFVGE 13827
>NP_001254479
          Length = 35991

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2     GAEVFVSE 9
             G EVFV E
Sbjct: 14327 GVEVFVGE 14334
>NP_597681
          Length = 27118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    GAEVFVSE 9
            G EVFV E
Sbjct: 5454 GVEVFVGE 5461
>NP_001254772
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DG+ ++VSE
Sbjct: 128 DGSIIYVSE 136
>NP_004889
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DG+ ++VSE
Sbjct: 128 DGSIIYVSE 136
>NP_631938
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGAEVFVSE 9
            D  EV+VSE
Sbjct: 1051 DQGEVYVSE 1059
>XP_005271912
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGAEVFVSE 9
            D  EV+VSE
Sbjct: 1124 DQGEVYVSE 1132
>XP_005271916
          Length = 1165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   DGAEVFVSE 9
           D  EV+VSE
Sbjct: 981 DQGEVYVSE 989
>XP_005271914
          Length = 1238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGAEVFVSE 9
            D  EV+VSE
Sbjct: 1054 DQGEVYVSE 1062
>XP_006714587
          Length = 1269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGAEVFVSE 9
            D  EV+VSE
Sbjct: 1085 DQGEVYVSE 1093
>XP_005271913
          Length = 1293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DGAEVFVSE 9
            D  EV+VSE
Sbjct: 1109 DQGEVYVSE 1117
>XP_006714117
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DG+ ++VSE
Sbjct: 128 DGSIIYVSE 136
>XP_005265844
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   DGAEVFVSE 9
           DG+ ++VSE
Sbjct: 128 DGSIIYVSE 136
>NP_001245143
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>NP_001245144
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>NP_001245145
          Length = 635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>NP_001550
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>NP_859070
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>NP_001231
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DGAEVFVSE 9
           DG+  F+S+
Sbjct: 367 DGSNAFISQ 375
>XP_006710680
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>XP_005270885
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>XP_005270884
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>XP_005270882
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GAEVFV 7
           GAE+FV
Sbjct: 115 GAEIFV 120
>XP_005245884
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_005245882
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_006710614
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_005245881
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_005245880
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_006710613
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
>XP_005245879
          Length = 634

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DGAEVFV 7
           +GA+VFV
Sbjct: 94  EGADVFV 100
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.131    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 447,508
Number of extensions: 716
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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