Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     175
XP_006717990                                                           21     175
XP_006717989                                                           21     175
NP_060809                                                              17    2528
NP_003304                                                              16    5631
NP_001229436                                                           16    5631
NP_001229435                                                           16    5631
NP_056382                                                              16    5631
NP_001229434                                                           16    5631
NP_004284                                                              16    5631
XP_006725157                                                           16    5631
XP_006725156                                                           16    5631
XP_005254096                                                           16    5631
XP_005254095                                                           16    5631
XP_006717389                                                           16    5631
XP_005252374                                                           16    5631
XP_005251109                                                           16    5631
XP_005251108                                                           16    5631
XP_005251107                                                           16    5631
NP_060868                                                              16    7355
NP_055426                                                              16    7355
NP_478072                                                              16    7355
XP_005248757                                                           16    7355
XP_006715468                                                           16    7355
XP_005248756                                                           16    7355
XP_006715467                                                           16    7355
XP_005265375                                                           16    7355
NP_001783                                                              15    9605
NP_001164100                                                           15    9605
NP_060250                                                              15    9605
NP_001229269                                                           15    9605
NP_776168                                                              15    9605
NP_065971                                                              15    9605
NP_001124429                                                           15    9605
NP_061172                                                              15    9605
NP_001013715                                                           15    9605
NP_079410                                                              15    9605
NP_001137296                                                           15    9605
NP_722580                                                              15    9605
NP_001006109                                                           15    9605
NP_060488                                                              15    9605
XP_005258239                                                           15    9605
XP_005258238                                                           15    9605
XP_005256233                                                           15    9605
XP_005256232                                                           15    9605
XP_005256231                                                           15    9605
XP_005256229                                                           15    9605
XP_005256228                                                           15    9605
XP_005256227                                                           15    9605
XP_006721346                                                           15    9605
XP_005256226                                                           15    9605
XP_006721345                                                           15    9605
XP_006721344                                                           15    9605
XP_006721343                                                           15    9605
XP_005256225                                                           15    9605
XP_005269054                                                           15    9605
XP_006716523                                                           15    9605
XP_006716522                                                           15    9605
XP_005251324                                                           15    9605
XP_005251323                                                           15    9605
XP_005247694                                                           15    9605
XP_005247693                                                           15    9605
XP_006711820                                                           15    9605
XP_005273147                                                           15    9605
XP_006711819                                                           15    9605
XP_005245930                                                           15    9605
NP_002207                                                              15    9605
NP_064572                                                              15    9605
>NP_000305
          Length = 403

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFYGEVSTR 9
           DFYGEV TR
Sbjct: 153 DFYGEVRTR 161
>XP_006717990
          Length = 175

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFYGEVSTR 9
           DFYGEV TR
Sbjct: 138 DFYGEVRTR 146
>XP_006717989
          Length = 388

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFYGEVSTR 9
           DFYGEV TR
Sbjct: 138 DFYGEVRTR 146
>NP_060809
          Length = 155

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DFYGEV 6
          DFYGE+
Sbjct: 89 DFYGEI 94
>NP_003304
          Length = 321

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 264 DFHGEVT 270
>NP_001229436
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 341 DFFGDIS 347
>NP_001229435
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 341 DFFGDIS 347
>NP_056382
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  DFYGEV 6
          D+YGE+
Sbjct: 42 DYYGEI 47
>NP_001229434
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 415 DFFGDIS 421
>NP_004284
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 415 DFFGDIS 421
>XP_006725157
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 270 DFHGEVT 276
>XP_006725156
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 384 DFHGEVT 390
>XP_005254096
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  DFYGEV 6
          D+YGE+
Sbjct: 42 DYYGEI 47
>XP_005254095
          Length = 958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  DFYGEV 6
          D+YGE+
Sbjct: 42 DYYGEI 47
>XP_006717389
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 415 DFFGDIS 421
>XP_005252374
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+G++S
Sbjct: 415 DFFGDIS 421
>XP_005251109
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 270 DFHGEVT 276
>XP_005251108
          Length = 441

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 384 DFHGEVT 390
>XP_005251107
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   DFYGEVS 7
           DF+GEV+
Sbjct: 447 DFHGEVT 453
>NP_060868
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DFYGEV 6
           DF+GE+
Sbjct: 876 DFFGEI 881
>NP_055426
          Length = 5596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFYGEVST 8
            DF+ +VST
Sbjct: 4561 DFWADVST 4568
>NP_478072
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   YGEVSTR 9
           YGEVS R
Sbjct: 193 YGEVSGR 199
>XP_005248757
          Length = 3591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFYGEVST 8
            DF+ +VST
Sbjct: 2556 DFWADVST 2563
>XP_006715468
          Length = 3744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFYGEVST 8
            DF+ +VST
Sbjct: 2709 DFWADVST 2716
>XP_005248756
          Length = 3905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFYGEVST 8
            DF+ +VST
Sbjct: 2870 DFWADVST 2877
>XP_006715467
          Length = 5550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFYGEVST 8
            DF+ +VST
Sbjct: 4561 DFWADVST 4568
>XP_005265375
          Length = 1085

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   DFYGEV 6
           DF+GE+
Sbjct: 870 DFFGEI 875
>NP_001783
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 387 FYGEV 391
>NP_001164100
          Length = 2581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1805 DFYRVVST 1812
>NP_060250
          Length = 2997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1973 DFYRVVST 1980
>NP_001229269
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 367 FYSKINTR 374
>NP_776168
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 518 FYSKINTR 525
>NP_065971
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1526 DFYRVVST 1533
>NP_001124429
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 518 FYSKINTR 525
>NP_061172
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   YGEVSTR 9
           YG +STR
Sbjct: 679 YGRLSTR 685
>NP_001013715
          Length = 272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DFYGEVST 8
           DF GEV++
Sbjct: 160 DFVGEVTS 167
>NP_079410
          Length = 2881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>NP_001137296
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>NP_722580
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  DFYGEV 6
          DF+GE+
Sbjct: 69 DFHGEI 74
>NP_001006109
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGEVSTR 9
           +GEVST+
Sbjct: 229 FGEVSTQ 235
>NP_060488
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>XP_005258239
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 356 FYGEV 360
>XP_005258238
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 369 FYGEV 373
>XP_005256233
          Length = 2391

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1338 DFYRVVST 1345
>XP_005256232
          Length = 2424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1371 DFYRVVST 1378
>XP_005256231
          Length = 2573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005256229
          Length = 2881

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005256228
          Length = 2882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005256227
          Length = 2897

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_006721346
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005256226
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_006721345
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_006721344
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_006721343
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005256225
          Length = 2898

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1845 DFYRVVST 1852
>XP_005269054
          Length = 547

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   FYGEV 6
           FYGEV
Sbjct: 390 FYGEV 394
>XP_006716523
          Length = 1912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFYGEVST 8
           DFY  VST
Sbjct: 888 DFYRVVST 895
>XP_006716522
          Length = 2192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1168 DFYRVVST 1175
>XP_005251324
          Length = 2996

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1973 DFYRVVST 1980
>XP_005251323
          Length = 2997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    DFYGEVST 8
            DFY  VST
Sbjct: 1973 DFYRVVST 1980
>XP_005247694
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGEVSTR 9
           +GEVST+
Sbjct: 187 FGEVSTQ 193
>XP_005247693
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGEVSTR 9
           +GEVST+
Sbjct: 229 FGEVSTQ 235
>XP_006711820
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 376 FYSKINTR 383
>XP_005273147
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 376 FYSKINTR 383
>XP_006711819
          Length = 884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   FYGEVSTR 9
           FY +++TR
Sbjct: 451 FYSKINTR 458
>XP_005245930
          Length = 286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DFYGEVST 8
           DF GEV++
Sbjct: 160 DFVGEVTS 167
>NP_002207
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FYGEVST 8
           FY +VST
Sbjct: 489 FYNQVST 495
>NP_064572
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGEVSTR 9
           +GEVST+
Sbjct: 229 FGEVSTQ 235
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.139    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 507,074
Number of extensions: 729
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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