Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              18    1135
NP_002871                                                              18    1135
XP_005250103                                                           18    1135
XP_005250102                                                           18    1135
XP_005265416                                                           18    1135
XP_005265415                                                           18    1135
XP_005265414                                                           18    1135
XP_005265412                                                           18    1135
NP_001107854                                                           17    4312
NP_001070651                                                           17    4312
NP_000539                                                              17    4312
NP_000945                                                              17    4312
NP_775859                                                              17    4312
XP_005255589                                                           17    4312
XP_005255588                                                           17    4312
XP_005255587                                                           17    4312
XP_005255586                                                           17    4312
XP_005255585                                                           17    4312
XP_005255584                                                           17    4312
NP_001154948                                                           16    5631
NP_078791                                                              16    5631
NP_055907                                                              16    5631
XP_006726694                                                           16    5631
XP_005255242                                                           16    5631
XP_005255241                                                           16    5631
XP_005255240                                                           16    5631
XP_005255239                                                           16    5631
XP_005268115                                                           16    5631
XP_005268114                                                           16    5631
XP_005268113                                                           16    5631
NP_003310                                                              16    7355
NP_597676                                                              16    7355
NP_001243779                                                           16    7355
NP_596869                                                              16    7355
NP_036419                                                              16    7355
NP_004450                                                              16    7355
NP_872579                                                              16    7355
XP_005257219                                                           16    7355
XP_005257218                                                           16    7355
XP_005257217                                                           16    7355
XP_005257216                                                           16    7355
XP_005257215                                                           16    7355
XP_005257214                                                           16    7355
XP_005257213                                                           16    7355
XP_005257212                                                           16    7355
XP_006721834                                                           16    7355
XP_005257211                                                           16    7355
XP_005257210                                                           16    7355
XP_005257209                                                           16    7355
XP_005257208                                                           16    7355
XP_006721833                                                           16    7355
XP_005257207                                                           16    7355
XP_005256935                                                           16    7355
XP_006713621                                                           16    7355
XP_006713620                                                           16    7355
XP_005246888                                                           16    7355
XP_006712788                                                           16    7355
XP_006712787                                                           16    7355
XP_006712786                                                           16    7355
NP_055531                                                              16    7355
NP_001254479                                                           16    7355
NP_597681                                                              16    7355
NP_733765                                                              15    9605
NP_001672                                                              15    9605
XP_005253945                                                           15    9605
>NP_004324
          Length = 766

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 594 DFGLATVKS 602
>NP_002871
          Length = 648

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 486 DFGLATVKS 494
>XP_005250103
          Length = 758

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 594 DFGLATVKS 602
>XP_005250102
          Length = 767

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 594 DFGLATVKS 602
>XP_005265416
          Length = 534

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 372 DFGLATVKS 380
>XP_005265415
          Length = 567

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 405 DFGLATVKS 413
>XP_005265414
          Length = 615

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 453 DFGLATVKS 461
>XP_005265412
          Length = 648

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DF LATVKS
Sbjct: 486 DFGLATVKS 494
>NP_001107854
          Length = 1784

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1633 DFKLGTIK 1640
>NP_001070651
          Length = 1740

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1589 DFKLGTIK 1596
>NP_000539
          Length = 1807

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1656 DFKLGTIK 1663
>NP_000945
          Length = 190

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DFRLATVKS 9
           DFR+AT+ S
Sbjct: 142 DFRMATLYS 150
>NP_775859
          Length = 1326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   RLATVKS 9
           RLATVKS
Sbjct: 512 RLATVKS 518
>XP_005255589
          Length = 1831

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1680 DFKLGTIK 1687
>XP_005255588
          Length = 1832

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1681 DFKLGTIK 1688
>XP_005255587
          Length = 1854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1703 DFKLGTIK 1710
>XP_005255586
          Length = 1855

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1704 DFKLGTIK 1711
>XP_005255585
          Length = 1875

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1724 DFKLGTIK 1731
>XP_005255584
          Length = 1898

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DFRLATVK 8
            DF+L T+K
Sbjct: 1747 DFKLGTIK 1754
>NP_001154948
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           DFR+ T+K
Sbjct: 333 DFRITTLK 340
>NP_078791
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           DFR+ T+K
Sbjct: 333 DFRITTLK 340
>NP_055907
          Length = 3661

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 163 DRRLATVK 170
>XP_006726694
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 111 DRRLATVK 118
>XP_005255242
          Length = 3609

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 111 DRRLATVK 118
>XP_005255241
          Length = 3637

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 111 DRRLATVK 118
>XP_005255240
          Length = 3663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 137 DRRLATVK 144
>XP_005255239
          Length = 3689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           D RLATVK
Sbjct: 163 DRRLATVK 170
>XP_005268115
          Length = 286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DFRLATVK 8
          DFR+ T+K
Sbjct: 75 DFRITTLK 82
>XP_005268114
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  DFRLATVK 8
          DFR+ T+K
Sbjct: 78 DFRITTLK 85
>XP_005268113
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DFRLATVK 8
           DFR+ T+K
Sbjct: 333 DFRITTLK 340
>NP_003310
          Length = 26926

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DFRLATVKS 9
            DF+ A VKS
Sbjct: 5680 DFQAANVKS 5688
>NP_597676
          Length = 27051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DFRLATVKS 9
            DF+ A VKS
Sbjct: 5805 DFQAANVKS 5813
>NP_001243779
          Length = 34350

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1     DFRLATVKS 9
             DF+ A VKS
Sbjct: 13104 DFQAANVKS 13112
>NP_596869
          Length = 33423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1     DFRLATVKS 9
             DF+ A VKS
Sbjct: 12177 DFQAANVKS 12185
>NP_036419
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFRLATVK 8
           D RL TVK
Sbjct: 312 DLRLCTVK 319
>NP_004450
          Length = 2903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>NP_872579
          Length = 2920

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1769 YRLQTVKS 1776
>XP_005257219
          Length = 2038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257218
          Length = 2957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257217
          Length = 2961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257216
          Length = 3015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257215
          Length = 3032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1769 YRLQTVKS 1776
>XP_005257214
          Length = 3094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1831 YRLQTVKS 1838
>XP_005257213
          Length = 3095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1832 YRLQTVKS 1839
>XP_005257212
          Length = 3095

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1832 YRLQTVKS 1839
>XP_006721834
          Length = 3100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257211
          Length = 3100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257210
          Length = 3104

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257209
          Length = 3148

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257208
          Length = 3157

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1894 YRLQTVKS 1901
>XP_006721833
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005257207
          Length = 3158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    FRLATVKS 9
            +RL TVKS
Sbjct: 1895 YRLQTVKS 1902
>XP_005256935
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFRLATVK 8
           D RL TVK
Sbjct: 237 DLRLCTVK 244
>XP_006713621
          Length = 622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFRLATVK 8
           D RL TVK
Sbjct: 319 DLRLCTVK 326
>XP_006713620
          Length = 785

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFRLATVK 8
           D RL TVK
Sbjct: 319 DLRLCTVK 326
>XP_005246888
          Length = 22663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DFRLATVKS 9
            DF+ A VKS
Sbjct: 1417 DFQAANVKS 1425
>XP_006712788
          Length = 24022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DFRLATVKS 9
            DF+ A VKS
Sbjct: 2776 DFQAANVKS 2784
>XP_006712787
          Length = 33978

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1     DFRLATVKS 9
             DF+ A VKS
Sbjct: 12732 DFQAANVKS 12740
>XP_006712786
          Length = 35484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1     DFRLATVKS 9
             DF+ A VKS
Sbjct: 14238 DFQAANVKS 14246
>NP_055531
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   DFRLATVK 8
           D RL TVK
Sbjct: 311 DLRLCTVK 318
>NP_001254479
          Length = 35991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1     DFRLATVKS 9
             DF+ A VKS
Sbjct: 14745 DFQAANVKS 14753
>NP_597681
          Length = 27118

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    DFRLATVKS 9
            DF+ A VKS
Sbjct: 5872 DFQAANVKS 5880
>NP_733765
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DFRLATVKS 9
           D RL ++KS
Sbjct: 162 DIRLTSIKS 170
>NP_001672
          Length = 997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DFRLATVKS 9
           D RL ++KS
Sbjct: 162 DIRLTSIKS 170
>XP_005253945
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   DFRLATVKS 9
           D RL ++KS
Sbjct: 162 DIRLTSIKS 170
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.133    0.347 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 272,681
Number of extensions: 334
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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