Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004324                                                              19     665
NP_002871                                                              19     665
XP_005250103                                                           19     665
XP_005250102                                                           19     665
XP_005265416                                                           19     665
XP_005265415                                                           19     665
XP_005265414                                                           19     665
XP_005265412                                                           19     665
NP_001243125                                                           18    1482
NP_001645                                                              18    1482
XP_006724592                                                           18    1482
NP_001036212                                                           17    3301
NP_001036194                                                           17    3301
NP_005239                                                              17    3301
XP_006710515                                                           17    3301
NP_055749                                                              16    5631
NP_945319                                                              16    5631
XP_006719984                                                           16    5631
XP_006719983                                                           16    5631
XP_006719982                                                           16    5631
XP_006719981                                                           16    5631
XP_006719980                                                           16    5631
XP_005254089                                                           16    5631
XP_006719979                                                           16    5631
NP_001265                                                              16    7355
NP_001231775                                                           16    7355
NP_001107593                                                           16    7355
NP_001107594                                                           16    7355
NP_001035351                                                           16    7355
NP_001035350                                                           16    7355
NP_694592                                                              16    7355
NP_694593                                                              16    7355
NP_002028                                                              16    7355
NP_005408                                                              16    7355
NP_938033                                                              16    7355
NP_008957                                                              16    7355
NP_005424                                                              16    7355
NP_001361                                                              16    7355
XP_006725363                                                           16    7355
XP_005257034                                                           16    7355
XP_006718822                                                           16    7355
XP_005266949                                                           16    7355
XP_005266947                                                           16    7355
XP_006715492                                                           16    7355
XP_005266946                                                           16    7355
XP_005266945                                                           16    7355
XP_005266944                                                           16    7355
XP_005262843                                                           16    7355
XP_005262842                                                           16    7355
XP_006712019                                                           16    7355
NP_001120694                                                           15    9605
NP_075461                                                              15    9605
NP_001120693                                                           15    9605
NP_000059                                                              15    9605
NP_067047                                                              15    9605
NP_001167551                                                           15    9605
NP_001182345                                                           15    9605
NP_004725                                                              15    9605
NP_001182344                                                           15    9605
NP_001274324                                                           15    9605
XP_006719956                                                           15    9605
XP_005266649                                                           15    9605
XP_006717280                                                           15    9605
XP_006717279                                                           15    9605
XP_006717278                                                           15    9605
XP_006717277                                                           15    9605
XP_006717276                                                           15    9605
XP_006717275                                                           15    9605
XP_006717274                                                           15    9605
XP_006717273                                                           15    9605
XP_006717272                                                           15    9605
NP_777592                                                              15    9605
>NP_004324
          Length = 766

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 594 DFGLATVKS 602
>NP_002871
          Length = 648

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 486 DFGLATVKS 494
>XP_005250103
          Length = 758

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 594 DFGLATVKS 602
>XP_005250102
          Length = 767

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 594 DFGLATVKS 602
>XP_005265416
          Length = 534

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 372 DFGLATVKS 380
>XP_005265415
          Length = 567

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 405 DFGLATVKS 413
>XP_005265414
          Length = 615

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 453 DFGLATVKS 461
>XP_005265412
          Length = 648

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVKS
Sbjct: 486 DFGLATVKS 494
>NP_001243125
          Length = 609

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVK+
Sbjct: 450 DFGLATVKT 458
>NP_001645
          Length = 606

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVK+
Sbjct: 447 DFGLATVKT 455
>XP_006724592
          Length = 611

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   DFGRATVKS 9
           DFG ATVK+
Sbjct: 452 DFGLATVKT 460
>NP_001036212
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FGR T+KS
Sbjct: 432 FGRFTIKS 439
>NP_001036194
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FGR T+KS
Sbjct: 432 FGRFTIKS 439
>NP_005239
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FGR T+KS
Sbjct: 432 FGRFTIKS 439
>XP_006710515
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FGR T+KS
Sbjct: 432 FGRFTIKS 439
>NP_055749
          Length = 848

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 693 FGKNTVKS 700
>NP_945319
          Length = 867

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 712 FGKNTVKS 719
>XP_006719984
          Length = 613

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 439 FGKNTVKS 446
>XP_006719983
          Length = 886

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 712 FGKNTVKS 719
>XP_006719982
          Length = 894

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 720 FGKNTVKS 727
>XP_006719981
          Length = 912

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 738 FGKNTVKS 745
>XP_006719980
          Length = 913

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 758 FGKNTVKS 765
>XP_005254089
          Length = 927

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 753 FGKNTVKS 760
>XP_006719979
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           FG+ TVKS
Sbjct: 758 FGKNTVKS 765
>NP_001265
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 148 DFGLATV 154
>NP_001231775
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 148 DFGLATV 154
>NP_001107593
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 148 DFGLATV 154
>NP_001107594
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 148 DFGLATV 154
>NP_001035351
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 554 DFGLATV 560
>NP_001035350
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 537 DFGLATV 543
>NP_694592
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 437 YGRFTIKS 444
>NP_694593
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 385 YGRFTIKS 392
>NP_002028
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 440 YGRFTIKS 447
>NP_005408
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 439 YGRFTIKS 446
>NP_938033
          Length = 536

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 439 YGRFTIKS 446
>NP_008957
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FGRATVK 8
           FG++TVK
Sbjct: 166 FGKSTVK 172
>NP_005424
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 446 YGRFTIKS 453
>NP_001361
          Length = 4158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    DFGRATVKS 9
            DFG   VKS
Sbjct: 1643 DFGMRAVKS 1651
>XP_006725363
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FGRATVK 8
           FG++TVK
Sbjct: 166 FGKSTVK 172
>XP_005257034
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   FGRATVK 8
           FG++TVK
Sbjct: 166 FGKSTVK 172
>XP_006718822
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 148 DFGLATV 154
>XP_005266949
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 385 YGRFTIKS 392
>XP_005266947
          Length = 534

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 437 YGRFTIKS 444
>XP_006715492
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 440 YGRFTIKS 447
>XP_005266946
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 440 YGRFTIKS 447
>XP_005266945
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 440 YGRFTIKS 447
>XP_005266944
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           +GR T+KS
Sbjct: 440 YGRFTIKS 447
>XP_005262843
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 536 DFGLATV 542
>XP_005262842
          Length = 782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG ATV
Sbjct: 553 DFGLATV 559
>XP_006712019
          Length = 4158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    DFGRATVKS 9
            DFG   VKS
Sbjct: 1643 DFGMRAVKS 1651
>NP_001120694
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           F RA++KS
Sbjct: 452 FARASIKS 459
>NP_075461
          Length = 2512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           F RA++KS
Sbjct: 453 FARASIKS 460
>NP_001120693
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           F RA++KS
Sbjct: 453 FARASIKS 460
>NP_000059
          Length = 2266

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           F RA++KS
Sbjct: 453 FARASIKS 460
>NP_067047
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>NP_001167551
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FGRATVKS 9
           F RA++KS
Sbjct: 453 FARASIKS 460
>NP_001182345
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG AT+
Sbjct: 226 DFGLATI 232
>NP_004725
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG AT+
Sbjct: 533 DFGLATI 539
>NP_001182344
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG AT+
Sbjct: 226 DFGLATI 232
>NP_001274324
          Length = 1688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    GRATVKS 9
            GR T+KS
Sbjct: 1296 GRVTIKS 1302
>XP_006719956
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG AT+
Sbjct: 533 DFGLATI 539
>XP_005266649
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   DFGRATV 7
           DFG AT+
Sbjct: 533 DFGLATI 539
>XP_006717280
          Length = 2221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717279
          Length = 2506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717278
          Length = 2566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717277
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717276
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717275
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717274
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717273
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>XP_006717272
          Length = 2567

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    DFGRATVK 8
            D+G  TVK
Sbjct: 1199 DYGNRTVK 1206
>NP_777592
          Length = 507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   DFGRATVK 8
           DFG  T+K
Sbjct: 150 DFGHPTLK 157
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.131    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 407,049
Number of extensions: 391
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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