Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005219                                                              19     869
NP_001276866                                                           18    1135
NP_004439                                                              18    1135
NP_001276865                                                           18    1135
NP_001005862                                                           18    1135
XP_005257197                                                           18    1135
XP_006721828                                                           18    1135
NP_789786                                                              17    4312
XP_005276824                                                           17    4312
XP_005276823                                                           17    4312
XP_005276822                                                           17    4312
XP_006726278                                                           17    4312
XP_005276821                                                           17    4312
XP_006726277                                                           17    4312
XP_005276820                                                           17    4312
XP_005276819                                                           17    4312
XP_005276818                                                           17    4312
XP_005248564                                                           17    4312
XP_005248520                                                           17    4312
XP_005248519                                                           17    4312
XP_005248518                                                           17    4312
XP_006714633                                                           17    4312
XP_005248517                                                           17    4312
XP_006714632                                                           17    4312
XP_005248516                                                           17    4312
XP_005248515                                                           17    4312
XP_005248514                                                           17    4312
NP_005900                                                              17    4312
NP_659488                                                              15    9605
NP_001768                                                              15    9605
NP_942088                                                              15    9605
XP_006717015                                                           15    9605
XP_005247966                                                           15    9605
XP_005247965                                                           15    9605
>NP_005219
          Length = 1210

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 761 DEAYVMASV 769
>NP_001276866
          Length = 1055

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 769 DEAYVMAGV 777
>NP_004439
          Length = 1255

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 769 DEAYVMAGV 777
>NP_001276865
          Length = 1240

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 754 DEAYVMAGV 762
>NP_001005862
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 739 DEAYVMAGV 747
>XP_005257197
          Length = 1225

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 739 DEAYVMAGV 747
>XP_006721828
          Length = 1336

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DEAYVMAVV 9
           DEAYVMA V
Sbjct: 850 DEAYVMAGV 858
>NP_789786
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 317 EEAYVMA 323
>XP_005276824
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 192 EEAYVMA 198
>XP_005276823
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 192 EEAYVMA 198
>XP_005276822
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 227 EEAYVMA 233
>XP_006726278
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 240 EEAYVMA 246
>XP_005276821
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 244 EEAYVMA 250
>XP_006726277
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 312 EEAYVMA 318
>XP_005276820
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 316 EEAYVMA 322
>XP_005276819
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 317 EEAYVMA 323
>XP_005276818
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 317 EEAYVMA 323
>XP_005248564
          Length = 2342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   EAYVMAVV 9
           E YVMAVV
Sbjct: 916 EDYVMAVV 923
>XP_005248520
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 192 EEAYVMA 198
>XP_005248519
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 192 EEAYVMA 198
>XP_005248518
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 227 EEAYVMA 233
>XP_006714633
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 240 EEAYVMA 246
>XP_005248517
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 244 EEAYVMA 250
>XP_006714632
          Length = 506

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 312 EEAYVMA 318
>XP_005248516
          Length = 510

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 316 EEAYVMA 322
>XP_005248515
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 317 EEAYVMA 323
>XP_005248514
          Length = 511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DEAYVMA 7
           +EAYVMA
Sbjct: 317 EEAYVMA 323
>NP_005900
          Length = 2468

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EAYVMAVV 9
            E YVMAVV
Sbjct: 1042 EDYVMAVV 1049
>NP_659488
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY+MAV+
Sbjct: 164 AYLMAVI 170
>NP_001768
          Length = 323

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY++AVV
Sbjct: 248 AYILAVV 254
>NP_942088
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY++AVV
Sbjct: 248 AYILAVV 254
>XP_006717015
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY+MAV+
Sbjct: 164 AYLMAVI 170
>XP_005247966
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY++AVV
Sbjct: 248 AYILAVV 254
>XP_005247965
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AYVMAVV 9
           AY++AVV
Sbjct: 248 AYILAVV 254
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.130    0.336 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 340,596
Number of extensions: 353
Number of successful extensions: 34
Number of sequences better than 10000.0: 34
Number of HSP's gapped: 34
Number of HSP's successfully gapped: 34
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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