Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005148                                                              20     509
NP_009297                                                              20     509
NP_951038                                                              16    5631
NP_001159817                                                           16    5631
NP_997046                                                              16    5631
NP_001360                                                              16    7355
NP_065825                                                              16    7355
XP_005248319                                                           16    7355
NP_689777                                                              15    9605
NP_060360                                                              15    9605
NP_001269633                                                           15    9605
NP_001269634                                                           15    9605
NP_001269635                                                           15    9605
NP_005733                                                              15    9605
NP_001269636                                                           15    9605
XP_005250858                                                           15    9605
XP_005250857                                                           15    9605
XP_005246202                                                           15    9605
XP_006711919                                                           15    9605
>NP_005148
          Length = 1130

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DAVNSDVAK 9
           DAVNSD AK
Sbjct: 939 DAVNSDAAK 947
>NP_009297
          Length = 1149

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   DAVNSDVAK 9
           DAVNSD AK
Sbjct: 958 DAVNSDAAK 966
>NP_951038
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVNSDVAK 9
           +VNSD++K
Sbjct: 249 SVNSDISK 256
>NP_001159817
          Length = 246

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AVNSDVAK 9
           +VNSD++K
Sbjct: 140 SVNSDISK 147
>NP_997046
          Length = 547

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DAVNSDVAK 9
           D+VNSD +K
Sbjct: 154 DSVNSDNSK 162
>NP_001360
          Length = 4624

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DAVNSDVA 8
            D +NSD+A
Sbjct: 3046 DEINSDLA 3053
>NP_065825
          Length = 1006

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   AVNSDVAK 9
           A N DVAK
Sbjct: 439 AANGDVAK 446
>XP_005248319
          Length = 4609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    DAVNSDVA 8
            D +NSD+A
Sbjct: 3031 DEINSDLA 3038
>NP_689777
          Length = 3997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VNSDVAK 9
            V+SDVAK
Sbjct: 1855 VDSDVAK 1861
>NP_060360
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VNSDVAK 9
            V+SDVAK
Sbjct: 1880 VDSDVAK 1886
>NP_001269633
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 332 EIINEDIAK 340
>NP_001269634
          Length = 488

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 328 EIINEDIAK 336
>NP_001269635
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 285 EIINEDIAK 293
>NP_005733
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 280 EIINEDIAK 288
>NP_001269636
          Length = 437

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 277 EIINEDIAK 285
>XP_005250858
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VNSDVAK 9
            V+SDVAK
Sbjct: 1880 VDSDVAK 1886
>XP_005250857
          Length = 4022

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VNSDVAK 9
            V+SDVAK
Sbjct: 1880 VDSDVAK 1886
>XP_005246202
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 280 EIINEDIAK 288
>XP_006711919
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   DAVNSDVAK 9
           + +N D+AK
Sbjct: 280 EIINEDIAK 288
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.113    0.277 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 366,477
Number of extensions: 355
Number of successful extensions: 19
Number of sequences better than 10000.0: 19
Number of HSP's gapped: 19
Number of HSP's successfully gapped: 19
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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