Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           20     509
NP_000170                                                              20     509
NP_001268422                                                           20     509
NP_001268423                                                           20     509
XP_005264328                                                           20     509
XP_006711950                                                           17    2528
XP_005264750                                                           17    2528
NP_057114                                                              17    2528
NP_001013648                                                           17    3301
NP_071755                                                              17    4312
NP_065854                                                              16    5631
NP_066988                                                              16    7355
NP_689598                                                              16    7355
NP_001129070                                                           16    7355
NP_065845                                                              16    7355
NP_056051                                                              16    7355
XP_006714219                                                           16    7355
XP_006714218                                                           16    7355
XP_006714217                                                           16    7355
XP_006714216                                                           16    7355
XP_006712003                                                           16    7355
XP_006712002                                                           16    7355
XP_006712001                                                           16    7355
XP_005264195                                                           16    7355
XP_006712000                                                           16    7355
XP_005264194                                                           16    7355
XP_005264193                                                           16    7355
XP_005245436                                                           16    7355
XP_006710845                                                           16    7355
NP_001171899                                                           15    9605
NP_775099                                                              15    9605
NP_056472                                                              15    9605
NP_009160                                                              15    9605
NP_001171900                                                           15    9605
XP_003403542                                                           15    9605
XP_005261376                                                           15    9605
XP_006724183                                                           15    9605
XP_006724182                                                           15    9605
XP_006724181                                                           15    9605
XP_006724180                                                           15    9605
XP_005268684                                                           15    9605
XP_003403793                                                           15    9605
NP_444513                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DAIEDLMLV 9
           DAIEDLM+V
Sbjct: 663 DAIEDLMVV 671
>NP_000170
          Length = 1360

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DAIEDLMLV 9
           DAIEDLM+V
Sbjct: 793 DAIEDLMVV 801
>NP_001268422
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DAIEDLMLV 9
           DAIEDLM+V
Sbjct: 491 DAIEDLMVV 499
>NP_001268423
          Length = 1058

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DAIEDLMLV 9
           DAIEDLM+V
Sbjct: 491 DAIEDLMVV 499
>XP_005264328
          Length = 1261

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   DAIEDLMLV 9
           DAIEDLM+V
Sbjct: 694 DAIEDLMVV 702
>XP_006711950
          Length = 389

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DAIEDLML 8
           DA++DLML
Sbjct: 351 DAVKDLML 358
>XP_005264750
          Length = 735

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DAIEDLML 8
           DA++DLML
Sbjct: 351 DAVKDLML 358
>NP_057114
          Length = 735

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   DAIEDLML 8
           DA++DLML
Sbjct: 351 DAVKDLML 358
>NP_001013648
          Length = 228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  DAIEDLML 8
          DAIEDL L
Sbjct: 41 DAIEDLSL 48
>NP_071755
          Length = 147

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   DAIEDLMLV 9
           D+IEDL +V
Sbjct: 134 DSIEDLKMV 142
>NP_065854
          Length = 620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   DAIEDLM 7
           DAIEDL+
Sbjct: 116 DAIEDLV 122
>NP_066988
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DAI DL+L
Sbjct: 695 DAIRDLIL 702
>NP_689598
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 522 DAVESLMI 529
>NP_001129070
          Length = 464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 400 DAVESLMI 407
>NP_065845
          Length = 1537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DAIEDLML 8
           +A+EDL+L
Sbjct: 253 EALEDLLL 260
>NP_056051
          Length = 1469

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+ DL+L
Sbjct: 870 DAVHDLLL 877
>XP_006714219
          Length = 806

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+ DL+L
Sbjct: 436 DAVHDLLL 443
>XP_006714218
          Length = 846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+ DL+L
Sbjct: 241 DAVHDLLL 248
>XP_006714217
          Length = 1013

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+ DL+L
Sbjct: 423 DAVHDLLL 430
>XP_006714216
          Length = 1026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+ DL+L
Sbjct: 436 DAVHDLLL 443
>XP_006712003
          Length = 256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 192 DAVESLMI 199
>XP_006712002
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 228 DAVESLMI 235
>XP_006712001
          Length = 306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 242 DAVESLMI 249
>XP_005264195
          Length = 460

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 396 DAVESLMI 403
>XP_006712000
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 413 DAVESLMI 420
>XP_005264194
          Length = 520

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 456 DAVESLMI 463
>XP_005264193
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DA+E LM+
Sbjct: 522 DAVESLMI 529
>XP_005245436
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   DAIEDLML 8
           DAI DL+L
Sbjct: 695 DAIRDLIL 702
>XP_006710845
          Length = 1492

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   DAIEDLML 8
           +A+EDL+L
Sbjct: 291 EALEDLLL 298
>NP_001171899
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>NP_775099
          Length = 2595

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    DAIEDLMLV 9
            DA++DL+ V
Sbjct: 2340 DALDDLVTV 2348
>NP_056472
          Length = 2277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    DAIEDLMLV 9
            DA++DL+ V
Sbjct: 2022 DALDDLVTV 2030
>NP_009160
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>NP_001171900
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>XP_003403542
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 291 DAVEDL 296
>XP_005261376
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>XP_006724183
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 237 DAVEDL 242
>XP_006724182
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>XP_006724181
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>XP_006724180
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 278 DAVEDL 283
>XP_005268684
          Length = 121

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DAIEDL 6
          DA+EDL
Sbjct: 86 DAVEDL 91
>XP_003403793
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   DAIEDL 6
           DA+EDL
Sbjct: 291 DAVEDL 296
>NP_444513
          Length = 110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  DAIEDL 6
          DA+EDL
Sbjct: 86 DAVEDL 91
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.146    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 411,512
Number of extensions: 411
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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