Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055646                                                              18    1135
XP_006713495                                                           18    1135
NP_055230                                                              17    2528
NP_006124                                                              17    3301
NP_004723                                                              17    3301
XP_005256906                                                           17    3301
XP_005274287                                                           17    3301
NP_055782                                                              17    4312
NP_000880                                                              17    4312
XP_006725604                                                           17    4312
XP_006725603                                                           17    4312
XP_006725602                                                           17    4312
XP_006725601                                                           17    4312
XP_006725600                                                           17    4312
XP_005254293                                                           17    4312
XP_005254289                                                           17    4312
XP_005254292                                                           17    4312
XP_005254291                                                           17    4312
XP_005254290                                                           17    4312
XP_006719439                                                           17    4312
XP_005268909                                                           17    4312
XP_005268908                                                           17    4312
NP_001073890                                                           16    7355
XP_006722755                                                           16    7355
NP_071434                                                              15    9605
NP_055146                                                              15    9605
NP_079058                                                              15    9605
NP_001277046                                                           15    9605
NP_001277047                                                           15    9605
XP_005262932                                                           15    9605
>NP_055646
          Length = 2925

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    CSVAELAIL 9
            CSV++LAIL
Sbjct: 1514 CSVSDLAIL 1522
>XP_006713495
          Length = 2969

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    CSVAELAIL 9
            CSV++LAIL
Sbjct: 1558 CSVSDLAIL 1566
>NP_055230
          Length = 1053

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   CSVAELAIL 9
           CS+A++AIL
Sbjct: 283 CSMADVAIL 291
>NP_006124
          Length = 1042

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  CSVAELAIL 9
          C +AE+AI+
Sbjct: 69 CMIAEMAII 77
>NP_004723
          Length = 404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   CSVAELAI 8
           C+VA+LAI
Sbjct: 342 CTVAQLAI 349
>XP_005256906
          Length = 375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   CSVAELAI 8
           C+VA+LAI
Sbjct: 313 CTVAQLAI 320
>XP_005274287
          Length = 1042

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  CSVAELAIL 9
          C +AE+AI+
Sbjct: 69 CMIAEMAII 77
>NP_055782
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>NP_000880
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   CSVAELA 7
           CSVAEL+
Sbjct: 513 CSVAELS 519
>XP_006725604
          Length = 904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_006725603
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_006725602
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_006725601
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_006725600
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_005254293
          Length = 904

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_005254289
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_005254292
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_005254291
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_005254290
          Length = 1017

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSVAELAI 8
           CSV ELA+
Sbjct: 812 CSVEELAL 819
>XP_006719439
          Length = 782

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   CSVAELA 7
           CSVAEL+
Sbjct: 513 CSVAELS 519
>XP_005268909
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   CSVAELA 7
           CSVAEL+
Sbjct: 513 CSVAELS 519
>XP_005268908
          Length = 798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   CSVAELA 7
           CSVAEL+
Sbjct: 513 CSVAELS 519
>NP_001073890
          Length = 1703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    CSVAELAI 8
            C+V ELA+
Sbjct: 1459 CAVVELAL 1466
>XP_006722755
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    CSVAELAI 8
            C+V ELA+
Sbjct: 1459 CAVVELAL 1466
>NP_071434
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  CSVAEL 6
          CSVAE+
Sbjct: 30 CSVAEI 35
>NP_055146
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CSVAELAI 8
           C + ELAI
Sbjct: 158 CEIPELAI 165
>NP_079058
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   CSVAELAIL 9
           C V ELA L
Sbjct: 148 CQVRELATL 156
>NP_001277046
          Length = 188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   CSVAELAI 8
           C+V+E+A+
Sbjct: 170 CTVSEMAL 177
>NP_001277047
          Length = 140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   CSVAELAI 8
           C+V+E+A+
Sbjct: 122 CTVSEMAL 129
>XP_005262932
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CSVAELAI 8
           C + ELAI
Sbjct: 158 CEIPELAI 165
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.330    0.135    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 341,029
Number of extensions: 452
Number of successful extensions: 30
Number of sequences better than 10000.0: 30
Number of HSP's gapped: 30
Number of HSP's successfully gapped: 30
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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