Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001139806                                                           18    1482
XP_006715737                                                           18    1482
NP_001276674                                                           17    3301
NP_001243728                                                           17    3301
NP_002037                                                              17    3301
NP_001276675                                                           17    3301
NP_001167635                                                           17    3301
XP_005258789                                                           17    3301
XP_006716048                                                           17    3301
XP_006716047                                                           17    3301
XP_005250400                                                           17    3301
XP_005250399                                                           17    3301
NP_055179                                                              17    3301
NP_001273708                                                           17    4312
NP_115669                                                              17    4312
XP_005252325                                                           17    4312
XP_006717365                                                           17    4312
XP_005252324                                                           17    4312
NP_001159906                                                           16    5631
NP_002206                                                              16    5631
NP_848558                                                              16    5631
NP_940857                                                              16    5631
NP_063945                                                              16    7355
NP_056224                                                              16    7355
NP_001863                                                              16    7355
NP_001265470                                                           16    7355
NP_775844                                                              16    7355
XP_006725823                                                           16    7355
XP_005252903                                                           16    7355
XP_005266316                                                           16    7355
XP_005266315                                                           16    7355
XP_005266314                                                           16    7355
XP_006717250                                                           16    7355
XP_005266151                                                           16    7355
NP_001138567                                                           16    7355
NP_005297                                                              16    7355
NP_066997                                                              15    9605
NP_006517                                                              15    9605
NP_001278340                                                           15    9605
NP_620305                                                              15    9605
NP_078966                                                              15    9605
NP_001271230                                                           15    9605
NP_067036                                                              15    9605
NP_001271231                                                           15    9605
NP_061155                                                              15    9605
NP_075556                                                              15    9605
NP_001136171                                                           15    9605
NP_001073936                                                           15    9605
NP_115571                                                              15    9605
NP_001092885                                                           15    9605
NP_001244119                                                           15    9605
NP_742017                                                              15    9605
XP_006724107                                                           15    9605
XP_006724106                                                           15    9605
XP_005260602                                                           15    9605
XP_006723938                                                           15    9605
XP_006723676                                                           15    9605
XP_006723675                                                           15    9605
XP_006723674                                                           15    9605
XP_006723673                                                           15    9605
XP_005258454                                                           15    9605
XP_005257607                                                           15    9605
XP_005257606                                                           15    9605
XP_006716259                                                           15    9605
XP_006716258                                                           15    9605
XP_005250789                                                           15    9605
XP_005250788                                                           15    9605
XP_005250787                                                           15    9605
XP_005250786                                                           15    9605
XP_006716257                                                           15    9605
XP_005250785                                                           15    9605
XP_005250783                                                           15    9605
XP_005250139                                                           15    9605
XP_006715810                                                           15    9605
XP_006715809                                                           15    9605
>NP_001139806
          Length = 1562

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS SLLAP
Sbjct: 234 CSLSLLAP 241
>XP_006715737
          Length = 1349

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS SLLAP
Sbjct: 234 CSLSLLAP 241
>NP_001276674
          Length = 335

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 152 CTTNCLAPL 160
>NP_001243728
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 110 CTTNCLAPL 118
>NP_002037
          Length = 335

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 152 CTTNCLAPL 160
>NP_001276675
          Length = 335

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 152 CTTNCLAPL 160
>NP_001167635
          Length = 899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS +LLAP
Sbjct: 737 CSEALLAP 744
>XP_005258789
          Length = 412

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 224 CTTNCLAPL 232
>XP_006716048
          Length = 899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS +LLAP
Sbjct: 737 CSEALLAP 744
>XP_006716047
          Length = 899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS +LLAP
Sbjct: 737 CSEALLAP 744
>XP_005250400
          Length = 899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS +LLAP
Sbjct: 737 CSEALLAP 744
>XP_005250399
          Length = 899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           CS +LLAP
Sbjct: 737 CSEALLAP 744
>NP_055179
          Length = 408

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   CSTSLLAPI 9
           C+T+ LAP+
Sbjct: 224 CTTNCLAPL 232
>NP_001273708
          Length = 991

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   STSLLAPI 9
           STSLL+P+
Sbjct: 604 STSLLSPL 611
>NP_115669
          Length = 1013

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   STSLLAPI 9
           STSLL+P+
Sbjct: 626 STSLLSPL 633
>XP_005252325
          Length = 1036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   STSLLAPI 9
           STSLL+P+
Sbjct: 649 STSLLSPL 656
>XP_006717365
          Length = 1062

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   STSLLAPI 9
           STSLL+P+
Sbjct: 675 STSLLSPL 682
>XP_005252324
          Length = 1076

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   STSLLAPI 9
           STSLL+P+
Sbjct: 689 STSLLSPL 696
>NP_001159906
          Length = 769

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   CSTSLL 6
           CSTSLL
Sbjct: 105 CSTSLL 110
>NP_002206
          Length = 911

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   CSTSLL 6
           CSTSLL
Sbjct: 247 CSTSLL 252
>NP_848558
          Length = 117

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  CSTSLLAP 8
          CS +L+AP
Sbjct: 4  CSCALMAP 11
>NP_940857
          Length = 5147

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    CSTSLLAP 8
            CS S LAP
Sbjct: 2784 CSQSCLAP 2791
>NP_063945
          Length = 644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAPI
Sbjct: 256 SFSLLAPI 263
>NP_056224
          Length = 3123

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           STS LAP+
Sbjct: 666 STSSLAPV 673
>NP_001863
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS ++L PI
Sbjct: 4  CSLAVLVPI 12
>NP_001265470
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS ++L PI
Sbjct: 4  CSLAVLVPI 12
>NP_775844
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           C+T LL+P
Sbjct: 449 CATLLLSP 456
>XP_006725823
          Length = 1825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    STSLLAPI 9
            STSL+ PI
Sbjct: 1620 STSLVTPI 1627
>XP_005252903
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CSTSLLAP 8
           C+T LL+P
Sbjct: 522 CATLLLSP 529
>XP_005266316
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS ++L PI
Sbjct: 23 CSLAVLVPI 31
>XP_005266315
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS ++L PI
Sbjct: 23 CSLAVLVPI 31
>XP_005266314
          Length = 442

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS ++L PI
Sbjct: 23 CSLAVLVPI 31
>XP_006717250
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAPI
Sbjct: 256 SFSLLAPI 263
>XP_005266151
          Length = 643

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAPI
Sbjct: 256 SFSLLAPI 263
>NP_001138567
          Length = 531

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   STSLLAP 8
           +TSLLAP
Sbjct: 366 TTSLLAP 372
>NP_005297
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   CSTSLLAPI 9
           CST LLA I
Sbjct: 95  CSTWLLAGI 103
>NP_066997
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2  STSLLAP 8
          STSLL P
Sbjct: 23 STSLLGP 29
>NP_006517
          Length = 1048

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CSTSLLAPI 9
           CS  L AP+
Sbjct: 420 CSPDLAAPL 428
>NP_001278340
          Length = 2108

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    STSLLAP 8
            STSLL P
Sbjct: 1326 STSLLVP 1332
>NP_620305
          Length = 2426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    STSLLAP 8
            STSLL P
Sbjct: 1326 STSLLVP 1332
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           STS+ API
Sbjct: 551 STSVAAPI 558
>NP_001271230
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAP+
Sbjct: 569 SMSLLAPL 576
>NP_067036
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS +LLA I
Sbjct: 63 CSPTLLADI 71
>NP_001271231
          Length = 1086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAP+
Sbjct: 568 SMSLLAPL 575
>NP_061155
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAP+
Sbjct: 606 SMSLLAPL 613
>NP_075556
          Length = 1709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           +TSL API
Sbjct: 969 TTSLAAPI 976
>NP_001136171
          Length = 975

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  TSLLAP 8
          TSLLAP
Sbjct: 47 TSLLAP 52
>NP_001073936
          Length = 1848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    CSTSLLAP 8
            C T LL+P
Sbjct: 1380 CQTLLLSP 1387
>NP_115571
          Length = 2303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    STSLLAP 8
            STSLL P
Sbjct: 1326 STSLLVP 1332
>NP_001092885
          Length = 987

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>NP_001244119
          Length = 999

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>NP_742017
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_006724107
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    STSLLAP 8
            STSLL P
Sbjct: 1326 STSLLVP 1332
>XP_006724106
          Length = 2459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    STSLLAP 8
            STSLL P
Sbjct: 1326 STSLLVP 1332
>XP_005260602
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CSTSLLAPI 9
           CS  L AP+
Sbjct: 420 CSPDLAAPL 428
>XP_006723938
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   CSTSLLAPI 9
           CS  L AP+
Sbjct: 420 CSPDLAAPL 428
>XP_006723676
          Length = 1385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           +TSL API
Sbjct: 645 TTSLAAPI 652
>XP_006723675
          Length = 1623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           +TSL API
Sbjct: 883 TTSLAAPI 890
>XP_006723674
          Length = 1701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           +TSL API
Sbjct: 969 TTSLAAPI 976
>XP_006723673
          Length = 1709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           +TSL API
Sbjct: 969 TTSLAAPI 976
>XP_005258454
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   CSTSLLAP 8
           CS +LL P
Sbjct: 137 CSLNLLGP 144
>XP_005257607
          Length = 203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS +LLA I
Sbjct: 63 CSPTLLADI 71
>XP_005257606
          Length = 219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  CSTSLLAPI 9
          CS +LLA I
Sbjct: 63 CSPTLLADI 71
>XP_006716259
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_006716258
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250789
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250788
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250787
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250786
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_006716257
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250785
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 322 TSLLAP 327
>XP_005250783
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 587 TSLLAP 592
>XP_005250139
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TSLLAP 8
           TSLLAP
Sbjct: 592 TSLLAP 597
>XP_006715810
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAP+
Sbjct: 569 SMSLLAPL 576
>XP_006715809
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   STSLLAPI 9
           S SLLAP+
Sbjct: 606 SMSLLAPL 613
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.130    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 479,895
Number of extensions: 1119
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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