Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005912                                                              19     869
XP_005248577                                                           19     869
XP_005248576                                                           19     869
NP_065871                                                              18    1482
XP_005260528                                                           18    1482
NP_055273                                                              17    2528
XP_005245150                                                           17    2528
XP_006711340                                                           17    2528
NP_066022                                                              16    5631
XP_006723369                                                           16    5631
NP_003652                                                              16    7355
NP_001130012                                                           16    7355
NP_663318                                                              16    7355
NP_001130013                                                           16    7355
NP_001243000                                                           16    7355
NP_079160                                                              16    7355
XP_005261853                                                           16    7355
XP_005261852                                                           16    7355
XP_005257603                                                           16    7355
XP_006722058                                                           16    7355
XP_005257602                                                           16    7355
XP_005268132                                                           16    7355
XP_006718551                                                           16    7355
XP_005273928                                                           16    7355
XP_006713095                                                           16    7355
XP_005245231                                                           16    7355
NP_689973                                                              16    7355
NP_071882                                                              15    9605
NP_001035292                                                           15    9605
XP_005262827                                                           15    9605
XP_006714170                                                           15    9605
XP_006714169                                                           15    9605
XP_006714168                                                           15    9605
XP_005262826                                                           15    9605
XP_006714167                                                           15    9605
XP_005264540                                                           15    9605
XP_006712138                                                           15    9605
>NP_005912
          Length = 1512

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RRLMAIAD 9
           RRLMAIAD
Sbjct: 854 RRLMAIAD 861
>XP_005248577
          Length = 1349

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RRLMAIAD 9
           RRLMAIAD
Sbjct: 691 RRLMAIAD 698
>XP_005248576
          Length = 1375

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   RRLMAIAD 9
           RRLMAIAD
Sbjct: 717 RRLMAIAD 724
>NP_065871
          Length = 1659

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   CRRLMAIA 8
           CRRLMA++
Sbjct: 901 CRRLMALS 908
>XP_005260528
          Length = 956

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   CRRLMAIA 8
           CRRLMA++
Sbjct: 198 CRRLMALS 205
>NP_055273
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CRRLMAIAD 9
           CR L+ IAD
Sbjct: 182 CRELLRIAD 190
>XP_005245150
          Length = 609

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CRRLMAIAD 9
           CR L+ IAD
Sbjct: 182 CRELLRIAD 190
>XP_006711340
          Length = 684

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   CRRLMAIAD 9
           CR L+ IAD
Sbjct: 257 CRELLRIAD 265
>NP_066022
          Length = 2564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CRRLMAIAD 9
          C R+ A+AD
Sbjct: 49 CSRIKALAD 57
>XP_006723369
          Length = 2394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  CRRLMAIAD 9
          C R+ A+AD
Sbjct: 49 CSRIKALAD 57
>NP_003652
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 156 RRLRALAD 163
>NP_001130012
          Length = 398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 156 RRLRALAD 163
>NP_663318
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 172 RRLRALAD 179
>NP_001130013
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 138 RRLRALAD 145
>NP_001243000
          Length = 5207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RRLMAIAD 9
            +RL+A+AD
Sbjct: 1079 KRLIAVAD 1086
>NP_079160
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CR LMAI
Sbjct: 179 CRGLMAI 185
>XP_005261853
          Length = 380

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 138 RRLRALAD 145
>XP_005261852
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 154 RRLRALAD 161
>XP_005257603
          Length = 5256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RRLMAIAD 9
            +RL+A+AD
Sbjct: 1128 KRLIAVAD 1135
>XP_006722058
          Length = 5256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RRLMAIAD 9
            +RL+A+AD
Sbjct: 1128 KRLIAVAD 1135
>XP_005257602
          Length = 5256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    RRLMAIAD 9
            +RL+A+AD
Sbjct: 1128 KRLIAVAD 1135
>XP_005268132
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CR LMAI
Sbjct: 179 CRGLMAI 185
>XP_006718551
          Length = 399

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 309 RRLRALAD 316
>XP_005273928
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 309 RRLRALAD 316
>XP_006713095
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  RRLMAIA 8
          RRLMA+A
Sbjct: 5  RRLMALA 11
>XP_005245231
          Length = 166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  CRRLMAI 7
          CRR MA+
Sbjct: 11 CRRKMAV 17
>NP_689973
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RRLMAIAD 9
           RRL A+AD
Sbjct: 309 RRLRALAD 316
>NP_071882
          Length = 673

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CRRLMAIA 8
           C R+MA+A
Sbjct: 541 CCRIMALA 548
>NP_001035292
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_005262827
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714170
          Length = 274

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714169
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714168
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_005262826
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_006714167
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   CRRLMAI 7
           CRR MA+
Sbjct: 137 CRRWMAL 143
>XP_005264540
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CRRLMAIA 8
           C R+MA+A
Sbjct: 540 CCRIMALA 547
>XP_006712138
          Length = 678

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   CRRLMAIA 8
           C R+MA+A
Sbjct: 546 CCRIMALA 553
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.144    0.468 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 352,006
Number of extensions: 416
Number of successful extensions: 37
Number of sequences better than 10000.0: 37
Number of HSP's gapped: 37
Number of HSP's successfully gapped: 37
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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